Gadd45a knockout alleviates cisplatin-induced hearing loss by inhibiting CXCL family protein expression

Wei-Long Wang; Sheng-Yu Zou; Dan-Qi Wang; Yue Liu; Jia-Wen Li; Fang-Zi Ke; Si-Hui Wen; Bo-Wen Xu; Kun Lin; Chun-Jiang Wei; Xiao-Long Fu; Qiao-Jun Fang; Xiao-Xiang Xu; Xiong Chen; Zu-Hong He

doi:10.1016/j.mmr.2026.100063

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Gadd45a knockout alleviates cisplatin-induced hearing loss by inhibiting CXCL family protein expression

RESEARCH | Updated：2026-09-09

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- Gadd45a knockout alleviates cisplatin-induced hearing loss by inhibiting CXCL family protein expression
- “A research team introduces its progress in preventing cisplatin-induced hearing loss. Researchers established the GADD45A-NF-κB1-CXCL signaling pathway through CRISPR-Cas9 screening, which provides solutions to solve chemotherapy ototoxicity problems.”
- Wei-Long Wang , Sheng-Yu Zou , Dan-Qi Wang , Yue Liu , Jia-Wen Li , Fang-Zi Ke , Si-Hui Wen , Bo-Wen Xu , Kun Lin , Chun-Jiang Wei , Xiao-Long Fu , Qiao-Jun Fang , Xiao-Xiang Xu , Xiong Chen , Zu-Hong He
- Military Medical Research (2026)
- Affiliations：
  Department of Otorhinolaryngology-Head and Neck Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
  Medical Science and Technology Innovation Center, Institute of Brain Science and Brain-inspired Research, Shandong Provincial Hospital, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, China
  Department of Otolaryngology-Head and Neck Surgery, the Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China
  Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Medicine, Advanced Institute for Life and Health, Southeast University, Nanjing 210096, China
  Department of Otolaryngology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China
- Author bio：
  *Qiao-Jun Fang, qiaojunfang@ahmu.edu.cn
  Xiao-Xiang Xu, zn003504@whu.edu.cn
  Xiong Chen, zn_chenxiong@whu.edu.cn
  Zu-Hong He, hezuhong@163.com
- Funds：
- DOI： 10.1016/j.mmr.2026.100063
  CLC：
- Accepted：07 August 2026 ，
- Accepted：
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Gadd45a knockout alleviates cisplatin-induced hearing loss by inhibiting CXCL family protein expression

DOI： 10.1016/j.mmr.2026.100063

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