Crosstalk in the brain tumor microenvironment: mechanisms, therapeutic strategies, and clinical advances

Gui-Long Tanzhu; Liu Chen; Jiao-Yang Ning; Gang Xiao; Su Wen; Ce Wang; Hao Wen; Ke-Qin Zhang; Jie Yang; Mu-Yuan Jia; Hai-Bin Deng; Thomas Michael Marti; Paul R Lockman; Rong-Rong Zhou

doi:10.1016/j.mmr.2026.100047

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Crosstalk in the brain tumor microenvironment: mechanisms, therapeutic strategies, and clinical advances

REVIEW | Updated：2026-08-21

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- Crosstalk in the brain tumor microenvironment: mechanisms, therapeutic strategies, and clinical advances
- “Brain tumors pose severe health threats with poor prognoses. This review introduces research progress in brain tumor microenvironment. Experts established the single-cell and spatial transcriptomics system, exploring cellular heterogeneity and spatial organization, which opens up a new direction for tumor development and therapeutic research.”
- Gui-Long Tanzhu , Liu Chen , Jiao-Yang Ning , Gang Xiao , Su Wen , Ce Wang , Hao Wen , Ke-Qin Zhang , Jie Yang , Mu-Yuan Jia , Hai-Bin Deng , Thomas Michael Marti , Paul R Lockman , Rong-Rong Zhou
- Military Medical Research (2026)
- Affiliations：
  Department of Oncology, Xiangya Hospital, Central South University, Changsha 410000, China
  Department of Radiation Oncology, Hunan Cancer Hospital/Affiliated Hospital of Xiangya School of Medicine, Central South University, Changsha 410000, China
  Key Laboratory of Translational Radiation Oncology, Department of Radiation Oncology, Hunan Cancer Hospital, Changsha 410000, China
  Department of Radiology, China-Japan Friendship Hospital, Beijing 100029, China
  Department of Nuclear Medicine, the Third Xiangya Hospital, Central South University, Changsha 410000, China
  Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410000, China
  Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410000, China
  National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410000, China
  Department of General Thoracic Surgery, Inselspital, Bern University Hospital, University of Bern, Bern 3008, Switzerland
  Department for BioMedical Research, University of Bern, Bern 3008, Switzerland
  Department of Pharmaceutical Sciences, West Virginia University School of Pharmacy, Morgantown, WV 26505, USA
  Department of Neuroscience, West Virginia University School of Medicine, Rockefeller Neuroscience Institute, Morgantown, WV 26505, USA
  Xiangya Lung Cancer Center, Xiangya Hospital, Central South University, Changsha 410000, China
- Author bio：
  Hai-Bin Deng, haibin.deng@csu.edu.cn;
  Thomas Michael Marti, thomas. Marti@insel.ch;
  Paul R Lockman, prlockman@hsc.wvu.edu
  *Rong-Rong Zhou, zhourr@csu.edu.cn;
- Funds：
- DOI： 10.1016/j.mmr.2026.100047
  CLC：
- Accepted：16 June 2026 ，
- Accepted：
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Crosstalk in the brain tumor microenvironment: mechanisms, therapeutic strategies, and clinical advances

DOI： 10.1016/j.mmr.2026.100047

AI Introduction

Full Text(HTML)

Figs( 12 ) Tabs( 6 )

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Publication Info

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