Engineered exosomes for diabetic foot ulcers: lessons learned, challenges remain

Hyun-Do Jung

doi:10.1016/j.mmr.2026.100022

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Engineered exosomes for diabetic foot ulcers: lessons learned, challenges remain

COMMENTARY | Updated：2026-05-11

- Engineered exosomes for diabetic foot ulcers: lessons learned, challenges remain
- Military Medical Research (2026)
- Affiliations：
  
  Division of Materials Science and Engineering, Hanyang University, Seoul 04763, Republic of Korea
- Author bio：
  
  *Hyun-Do Jung, hdjung@hanyang.ac.kr
- Funds：
- DOI：10.1016/j.mmr.2026.100022
  CLC：
- Received：14 December 2025，
  
  Accepted：23 March 2026，
  
  Published：2026-04
- Accepted：
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Jung HD. Engineered exosomes for diabetic foot ulcers: lessons learned, challenges remain. Mil Med Res. 2026;13(1):100022.
DOI：

Jung HD. Engineered exosomes for diabetic foot ulcers: lessons learned, challenges remain. Mil Med Res. 2026;13(1):100022. DOI： 10.1016/j.mmr.2026.100022.

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references

Wang SQ , Jin MJ , Guo ZK , Shen DR , Jin LN , Cheng F , et al . Trace element-dictated exosome modules and self-adaptive dual-network hydrogel orchestrate diabetic foot regeneration through complement-mitochondria-autophagy circuitry . Mil Med Res . 2025 ; 12 ( 1 ): 71 .

Smith M , Johnston K , Withnall R . Systematic approach to delivering prolonged field care in a prehospital care environment . BMJ Mil Health . 2021 ; 167 ( 2 ): 93 - 8 .

Moon CH , Ko HG , Lee H , Bang S , Kang HS , Gwon JY , et al . Mesenchymal stem cell-inspired microneedle platform for NIR-responsive immunomodulation and accelerated chronic wound healing . Adv Mater . 2026 ; 38 ( 11 ): e14081 .

Kim N , Lee H , Han G , Kang M , Park S , Kim DE , et al . 3D-printed functional hydrogel by DNA-induced biomineralization for accelerated diabetic wound healing . Adv Sci (Weinh) . 2023 ; 10 ( 17 ): e2300816 .

Welsh JA , Goberdhan DCI , O'Driscoll L , Buzas EI , Blenkiron C , Bussolati B , et al . Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches . J Extracell Vesicles . 2024 ; 13 ( 2 ): e12404 .

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