

FOLLOWUS
Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
Department of Anesthesiology, Peking University People’s Hospital; Department of Anesthesiology, Women and Children’s Hospital, Qingdao University, Qingdao 266000, Shandong, China
Department of Biomaterials and Biomedical Technology, Personalized Medicine Research Institute (PRECISION), University Medical Center Groningen (UMCG), University of Groningen, Groningen 9713 AV, the Netherlands
*Yuan Xiong, xiongyuan@hust.edu.cn;
Mohammad-Ali Shahbazi, m.a.shahbazi@umcg.nl;
Bo-Bin Mi, mibobin@hust.edu.cn
Received:29 September 2025,
Accepted:06 March 2026,
Published:2026-04
Scan QR Code
Xiong Y, Wu QP, Wang H, Shahbazi MA, Mi BB. ROS-responsive drug delivery systems for chronic wound healing: advances, challenges, and translational perspectives. Mil Med Res. 2026;13(1):100019.
Xiong Y, Wu QP, Wang H, Shahbazi MA, Mi BB. ROS-responsive drug delivery systems for chronic wound healing: advances, challenges, and translational perspectives. Mil Med Res. 2026;13(1):100019. DOI: 10.1016/j.mmr.2026.100019.
Chronic wounds pose a substantial global health burden
due to the high incidence and recurrence rates
and associated morbidity. Excessive and sustained production of reactive oxygen species (ROS) is a hallmark of the chronic wound microenvironment
ultimately stalling the repair process. The pathological accumulation of ROS in chronic wounds has motivated the development of ROS-responsive drug delivery systems (DDS)
which show considerable potential in improving wound healing outcomes. In this review
we provide a comprehensive overview of the advances in ROS-responsive DDS for chronic wound healing
summarizing the design principles
material chemistry
and underlying ROS-triggered functional mechanisms. Key translational challenges are discussed
including material biocompatibility
stability in protease- and ROS-rich wound exudates
manufacturing scalability
and regulatory considerations. Finally
we outline future perspectives
emphasizing the integration of multi-responsive functionalities
real-time ROS monitoring
and advanced biomaterial engineering to accelerate clinical translation. By aligning therapeutic release with the dynamic redox status of chronic wounds
ROS-responsive DDS holds considerable potential to redefine precision therapy for wound management.
Sen CK . Human wound and its burden: updated 2025 compendium of estimates . Adv Wound Care (New Rochelle) . 2025 ; 14 ( 9 ): 429 - 38 .
Graves N , Phillips CJ , Harding K . A narrative review of the epidemiology and economics of chronic wounds . Br J Dermatol . 2022 ; 187 ( 2 ): 141 - 8 .
Huelsboemer L , Knoedler L , Kochen A , Yu CT , Hosseini H , Hollmann KS , et al . Cellular therapeutics and immunotherapies in wound healing-on the pulse of time? . Mil Med Res . 2024 ; 11 ( 1 ): 23 .
Martinengo L , Olsson M , Bajpai R , Soljak M , Upton Z , Schmidtchen A , et al . Prevalence of chronic wounds in the general population: systematic review and meta-analysis of observational studies . Ann Epidemiol . 2019 ; 29 : 8 - 15 .
Sen CK . Human wound and its burden: updated 2020 compendium of estimates . Adv Wound Care (New Rochelle) . 2021 ; 10 ( 5 ): 281 - 92 .
Xiong Y , Mi BB , Shahbazi MA , Xia T , Xiao J . Microenvironment-responsive nanomedicines: a promising direction for tissue regeneration . Mil Med Res . 2024 ; 11 ( 1 ): 69 .
Pena OA , Martin P . Cellular and molecular mechanisms of skin wound healing . Nat Rev Mol Cell Biol . 2024 ; 25 ( 8 ): 599 - 616 .
Li S , Lu L , Xiong Y , Xiao J . Nanomedicine-based immunotherapy for tissue regeneration . Burns Trauma . 2025 ; 13 : tkaf015 .
Ruzicka J , Dejmek J , Bolek L , Benes J , Kuncova J . Hyperbaric oxygen influences chronic wound healing - a cellular level review . Physiol Res . 2021 ; 70 ( S3 ): S261 - S73 .
Shi R , Zhu Y , Chen Y , Lin Y , Shi S . Advances in DNA nanotechnology for chronic wound management: Innovative functional nucleic acid nanostructures for overcoming key challenges . J Control Release . 2024 ; 375 : 155 - 77 .
Hunt M , Torres M , Bachar-Wikstrom E , Wikstrom JD . Cellular and molecular roles of reactive oxygen species in wound healing . Commun Biol . 2024 ; 7 ( 1 ): 1534 .
Ukaegbu K , Allen E , Svoboda KKH . Reactive oxygen species and antioxidants in wound healing: mechanisms and therapeutic potential . Int Wound J . 2025 ; 22 ( 5 ): e70330 .
Wlaschek M , Singh K , Sindrilaru A , Crisan D , Scharffetter-Kochanek K . Iron and iron-dependent reactive oxygen species in the regulation of macrophages and fibroblasts in non-healing chronic wounds . Free Radic Biol Med . 2019 ; 133 : 262 - 75 .
Xiong Y , Chu X , Yu T , Knoedler S , Schroeter A , Lu L , et al . Reactive oxygen species-scavenging nanosystems in the treatment of diabetic wounds . Adv Healthc Mater . 2023 ; 12 ( 25 ): e2300779 .
Huang F , Lu X , Kuai L , Ru Y , Jiang J , Song J , et al . Dual-site biomimetic Cu/Zn-MOF for atopic dermatitis catalytic therapy via suppressing FCγR-mediated phagocytosis . J Am Chem Soc . 2024 ; 146 ( 5 ): 3186 - 99 .
Xiong Y , Knoedler S , Alfertshofer M , Kim BS , Jiang D , Liu G , et al . Mechanisms and therapeutic opportunities in metabolic aberrations of diabetic wounds: a narrative review . Cell Death Dis . 2025 ; 16 ( 1 ): 341 .
Deng QS , Gao Y , Rui BY , Li XR , Liu PL , Han ZY , et al . Double-network hydrogel enhanced by SS31-loaded mesoporous polydopamine nanoparticles: symphonic collaboration of near-infrared photothermal antibacterial effect and mitochondrial maintenance for full-thickness wound healing in diabetes mellitus . Bioact Mater . 2023 ; 27 : 409 - 28 .
Zhou W , Xiong P , Ge Y , He Y , Sun Y , Zhang G , et al . Amoeba-inspired soft robot for integrated tumor/infection therapy and painless postoperative drainage . Adv Sci (Weinh) . 2024 ; 11 ( 47 ): e2407148 .
Moloney JN , Cotter TG . ROS signalling in the biology of cancer . Semin Cell Dev Biol . 2018 ; 80 : 50 - 64 .
Block ML , Zecca L , Hong JS . Microglia-mediated neurotoxicity: uncovering the molecular mechanisms . Nat Rev Neurosci . 2007 ; 8 ( 1 ): 57 - 69 .
Shah MS , Brownlee M . Molecular and cellular mechanisms of cardiovascular disorders in diabetes . Circ Res . 2016 ; 118 ( 11 ): 1808 - 29 .
Knoedler S , Knoedler L , Kauke-Navarro M , Rinkevich Y , Hundeshagen G , Harhaus L , et al . Regulatory T cells in skin regeneration and wound healing . Mil Med Res . 2023 ; 10 ( 1 ): 49 .
Chang M , Nguyen TT . Strategy for treatment of infected diabetic foot ulcers . Acc Chem Res . 2021 ; 54 ( 5 ): 1080 - 93 .
Lyons OT , Saha P , Smith A . Redox dysregulation in the pathogenesis of chronic venous ulceration . Free Radic Biol Med . 2020 ; 149 : 23 - 9 .
Ruan Y , Cheng J , Dai J , Ma Z , Luo S , Yan R , et al . Chronic stress hinders sensory axon regeneration via impairing mitochondrial cristae and OXPHOS . Sci Adv . 2023 ; 9 ( 40 ): eadh0183 .
Bortolotti M , Polito L , Battelli MG , Bolognesi A . Xanthine oxidoreductase: one enzyme for multiple physiological tasks . Redox Biol . 2021 ; 41 : 101882 .
Luo X , Xiong H , Jiang Y , Fan Y , Zuo C , Chen D , et al . Macrophage reprogramming via targeted ROS scavenging and COX-2 downregulation for alleviating inflammation . Bioconjug Chem . 2023 ; 34 ( 7 ): 1316 - 26 .
Yang WS , Kim KJ , Gaschler MM , Patel M , Shchepinov MS , Stockwell BR . Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis . Proc Natl Acad Sci U S A . 2016 ; 113 ( 34 ): E4966 - 75 .
Forstermann U , Xia N , Li H . Roles of vascular oxidative stress and nitric oxide in the pathogenesis of atherosclerosis . Circ Res . 2017 ; 120 ( 4 ): 713 - 35 .
Cheng H , Shi Z , Yue K , Huang X , Xu Y , Gao C , et al . Sprayable hydrogel dressing accelerates wound healing with combined reactive oxygen species-scavenging and antibacterial abilities . Acta Biomater . 2021 ; 124 : 219 - 32 .
Lin HY , Wang SW , Mao JY , Chang HT , Harroun SG , Lin HJ , et al . Carbonized nanogels for simultaneous antibacterial and antioxidant treatment of bacterial keratitis . Chem Eng J . 2021 ; 411 : 128469 .
Horak RD , Ciemniecki JA , Newman DK . Bioenergetic suppression by redox-active metabolites promotes antibiotic tolerance in Pseudomonas aeruginosa . Proc Natl Acad Sci U S A . 2024 ; 121 ( 46 ): e2406555121 .
Yu YL , Wu JJ , Lin CC , Qin X , Tay FR , Miao L , et al . Elimination of methicillin-resistant Staphylococcus aureus biofilms on titanium implants via photothermally-triggered nitric oxide and immunotherapy for enhanced osseointegration . Mil Med Res . 2023 ; 10 ( 1 ): 21 .
Jian HJ , Anand A , Lai JY , Unnikrishnan B , Chang HT , Harroun SG , et al . In situ hybridization of polymeric curcumin to arginine-derived carbon quantum dots for synergistic treatment of bacterial infections . ACS Appl Mater Interfaces . 2023 ; 15 ( 22 ): 26457 - 71 .
Jian HJ , Chiou YR , Anand A , Chen CF , Ma DHK , Lai JY , et al . Carbon-in-carbon: hybrid carbonized nanomaterials with multifunctional activities for the treatment of endophthalmitis . Chem Eng J . 2024 ; 491 : 151997 .
Wang S , Liu Y , Sun Q , Zeng B , Liu C , Gong L , et al . Triple cross-linked dynamic responsive hydrogel loaded with selenium nanoparticles for modulating the inflammatory microenvironment via PI3K/Akt/NF-kappaB and MAPK signaling pathways . Adv Sci (Weinh) . 2023 ; 10 ( 31 ): e2303167 .
Zhu Y , Chang B , Pang Y , Wang H , Zhou Y . Advances in hypoxia-inducible factor-1α stabilizer deferoxamine in tissue engineering . Tissue Eng Part B Rev . 2023 ; 29 ( 4 ): 347 - 57 .
Li H , Wei S , Ling Q , Wang R , Liu T , Yu H , et al . Nanozyme-reinforced hydrogel spray as a reactive oxygen species-driven oxygenator to accelerate diabetic wound healing . Adv Mater . 2025 ; 37 ( 34 ): e2504829 .
Yan Z , Zhang Y , Chen Q , Li J , Ning X , Bai F , et al . Carbon dot superoxide dismutase nanozyme enhances reactive oxygen species scavenging in diabetic skin wound repair . J Adv Res . 2026 ; 79 : 691 - 706 .
Chen R , Xu H , Li X , Dong J , Wang S , Hao J , et al . Role of oxidative stress in post-burn wound healing . Burns Trauma . 2025 ; 13 : tkaf040 .
Krishnamurthy HK , Pereira M , Rajavelu I , Jayaraman V , Krishna K , Wang T , et al . Oxidative stress: fundamentals and advances in quantification techniques . Front Chem . 2024 ; 12 : 1470458 .
Chen B , Yang Y , Wang Y , Yan Y , Wang Z , Yin Q , et al . Precise monitoring of singlet oxygen in specific endocytic organelles by super-pH-resolved nanosensors . ACS Appl Mater Interfaces . 2021 ; 13 ( 16 ): 18533 - 44 .
Singh S , Numan A , Khalid M , Bello I , Panza E , Cinti S . Facile and affordable design of mxene-Co 3 O 4 -based nanocomposites for detection of hydrogen peroxide in cancer cells: toward portable tool for cancer management . Small . 2023 ; 19 ( 51 ): e2208209 .
Garcia-Diaz M , Huang YY , Hamblin MR . Use of fluorescent probes for ROS to tease apart type I and type II photochemical pathways in photodynamic therapy . Methods . 2016 ; 109 : 158 - 66 .
Sarkar J , Das M , Howlader MSI , Prateeksha P , Barthels D , Das H . Epigallocatechin-3-gallate inhibits osteoclastic differentiation by modulating mitophagy and mitochondrial functions . Cell Death Dis . 2022 ; 13 ( 10 ): 908 .
Shanmugam G , Narasimhan M , Tamowski S , Darley-Usmar V , Rajasekaran NS . Constitutive activation of NRF2 induces a stable reductive state in the mouse myocardium . Redox Biol . 2017 ; 12 : 937 - 45 .
Wang L , Hou X , Fang H , Yang X . Boronate-based fluorescent probes as a prominent tool for H 2 O 2 sensing and recognition . Curr Med Chem . 2022 ; 29 ( 14 ): 2476 - 89 .
Geng Y , Wang Z , Zhou J , Zhu M , Liu J , James TD . Recent progress in the development of fluorescent probes for imaging pathological oxidative stress . Chem Soc Rev . 2023 ; 52 ( 11 ): 3873 - 926 .
Huang, Y , Liang, J , Fan, Z . A review: small organic molecule dual/multi-organelle-targeted fluorescent probes . Talanta . 2023 ; 259 : 124529 .
Perez E , Vazquez L , Quintana C , Petit-Dominguez MD , Casero E , Blanco E . Synergistic effect of manganese (II) phosphate & diamond nanoparticles in electrochemical sensors for reactive oxygen species determination in seminal plasma . Anal Chim Acta . 2023 ; 1264 : 341301 .
Zhang T , Tian T , Lin Y . Functionalizing framework nucleic-acid-based nanostructures for biomedical application . Adv Mater . 2022 ; 34 ( 46 ): e2107820 .
Wu, L , Sedgwick, AC , Sun, X , Bull, SD , He, XP , James, TD . Reaction-based fluorescent probes for the detection and imaging of reactive oxygen, nitrogen, and sulfur species . Acc Chem Res . 2019 ; 52 ( 9 ): 2582 - 97 .
Yu X , Ouyang W , Qiu H , Zhang Z , Wang Z , Xing B . Detection of reactive oxygen and nitrogen species by upconversion nanoparticle-based near-infrared nanoprobes: recent progress and perspectives . Chemistry . 2022 ; 28 ( 65 ): e202201966 .
Zhao S , Zang G , Zhang Y , Liu H , Wang N , Cai S , et al . Recent advances of electrochemical sensors for detecting and monitoring ROS/RNS . Biosens Bioelectron . 2021 ; 179 : 113052 .
Munteanu IG , Apetrei C . Analytical methods used in determining antioxidant activity: a review . Int J Mol Sci . 2021 ; 22 ( 7 ): 3380 .
Eruslanov E , Kusmartsev, S . Identification of ROS using oxidized DCFDA and flow-cytometry . Methods Mol Biol . 2010 ; 594 : 57 - 72 .
Miller EW , Albers AE , Pralle A , Isacoff EY , Chang CJ . Boronate-based fluorescent probes for imaging cellular hydrogen peroxide . J Am Chem Soc . 2005 ; 127 ( 47 ): 16652 - 9 .
Lara-Rojas F , Juarez-Verdayes MA , Wu HM , Cheung AY , Montiel J , Pascual-Morales E , et al . Using hyper as a molecular probe to visualize hydrogen peroxide in living plant cells: an updated method . Methods Enzymol . 2023 ; 683 : 265 - 89 .
Kumar R , Gullapalli RR . High throughput screening assessment of reactive oxygen species (ROS) generation using dihydroethidium (DHE) fluorescence dye . J Vis Exp . 2024 ; 203 : 10.3791/66238 https://doi.org/10.3791/66238 .
Kauffman ME , Kauffman MK , Traore K , Zhu H , Trush MA , Jia Z , et al . MitoSOX-based flow cytometry for detecting mitochondrial ROS . React Oxyg Species (Apex) . 2016 ; 2 ( 5 ): 361 - 70 .
Cohn CA , Pedigo CE , Hylton SN , Simon SR , Schoonen MA . Evaluating the use of 3’-(p-Aminophenyl) fluorescein for determining the formation of highly reactive oxygen species in particle suspensions . Geochem Trans . 2009 ; 10 : 8 .
Sugimoto W , Miyoshi D , Kawauchi K . Detection of intracellular reactive oxidative species using the fluorescent probe hydroxyphenyl fluorescein . Methods Mol Biol . 2021 ; 2274 : 207 - 15 .
Hachfi S , Benguettat O , Gallet A . Hypochlorous acid staining with R19-S in the Drosophila intestine upon ingestion of opportunistic bacteria . Bio Protoc . 2019 ; 9 ( 10 ): e3246 .
Song ZG , Yuan Q , Lv P , Chen K . Research progress of small molecule fluorescent probes for detecting hypochlorite . Sensors (Basel) . 2021 ; 21 ( 19 ): 6326 .
Zhang Y , Liu D , Chen W , Tao Y , Li W , Qi J . Microenvironment-activatable probe for precise NIR-II monitoring and synergistic immunotherapy in rheumatoid arthritis . Adv Mater 2024 ; 36 ( 48 ): e2409661 .
Murphy MP , Bayir H , Belousov V , Chang CJ , Davies KJA , Davies MJ , et al . Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo . Nat Metab 2022 ; 4 ( 6 ): 651 - 62 .
Zhang W , Hao L , Huang J , Xia L , Cui M , Zhang X , et al . Chemiluminescence chitosan hydrogels based on the luminol analog L-012 for highly sensitive detection of ROS . Talanta 2019 ; 201 : 455 - 9 .
Kim H , An HJ , Park J , Lee Y , Kim MS , Lee S , et al . Ultrasensitive and real-time optical detection of cellular oxidative stress using graphene-covered tunable plasmonic interfaces . Nano Converg . 2022 ; 9 ( 1 ): 23 .
Olson KR , Gao Y , Arif F , Arora K , Patel S , DeLeon ER , et al . Metabolism of hydrogen sulfide (H2S) and production of reactive sulfur species (RSS) by superoxide dismutase . Redox Biol . 2018 ; 15 : 74 - 85 .
Shen J , Shi W , Liu G , Zhuang W , Wang K , Wang Y , et al . Early diagnosis and treatment of osteoarthritis with a Au@PDA-WL NP nano-probe by photoacoustic imaging . J Mater Chem B . 2023 ; 11 ( 25 ): 5777 - 85 .
Ge C , Zhu J , Wu G , Ye H , Lu H , Yin L . ROS-responsive selenopolypeptide micelles: preparation, characterization, and controlled drug release . Biomacromolecules . 2022 ; 23 ( 6 ): 2647 - 54 .
Li J , Du Y , Wang J , Liu T , Zhu H , Ma J , et al . Optimizing type H vessels formation via short fibers 3D scaffolds with maintaining redox homeostasis for osteoporotic bone remodeling . Bioact Mater . 2025 ; 53 : 417 - 32 .
Lu Z , Chai Q , Dai W , Yu B , Lv Q , Qiu F , et al . Mitochondrial homeostasis restoring peptide-drug conjugates with ROS-responsive NO releasing ability for targeted therapy of myocardial infarction . J Nanobiotechnology 2025 ; 23 ( 1 ): 496 .
Jin L , Zhu Z , Hong L , Qian Z , Wang F , Mao Z . ROS-responsive 18β-glycyrrhetic acid-conjugated polymeric nanoparticles mediate neuroprotection in ischemic stroke through HMGB1 inhibition and microglia polarization regulation . Bioact Mater . 2023 ; 19 : 38 - 49 .
Li H , Li Y , Zhang L , Wang N , Lu D , Tang D , et al . Prodrug-inspired adenosine triphosphate-activatable celastrol-Fe(III) chelate for cancer therapy . Sci Adv . 2024 ; 10 ( 28 ): eadn0960 .
Zhang SJ , Xu R , He SB , Sun R , Wang GN , Wei SY , et al . Nanozyme-driven multifunctional dressings: moving beyond enzyme-like catalysis in chronic wound treatment . Mil Med Res . 2025 ; 12 ( 1 ): 27 .
Tao L , Ma X , Yang Y , Wang H , Yang X , Luo Y . Continuous pressure exacerbates ischemia-reperfusion injury in minipigs through the Akt/eNOS signaling pathway . Eur J Med Res . 2025 ; 31 ( 1 ): 26 .
Qu J , Zhao X , Liang Y , Zhang T , Ma PX , Guo B . Antibacterial adhesive injectable hydrogels with rapid self-healing, extensibility and compressibility as wound dressing for joints skin wound healing . Biomaterials . 2018 ; 183 : 185 - 99 .
Chen Y , Wang X , Tao S , Wang Q , Ma PQ , Li ZB , et al . Research advances in smart responsive-hydrogel dressings with potential clinical diabetic wound healing properties . Mil Med Res . 2023 ; 10 ( 1 ): 37 .
Wang G , Yang F , Zhou W , Xiao N , Luo M , Tang Z . The initiation of oxidative stress and therapeutic strategies in wound healing . Biomed Pharmacother . 2023 ; 157 : 114004 .
Li G , Ko CN , Li D , Yang C , Wang W , Yang GJ , et al . A small molecule HIF-1alpha stabilizer that accelerates diabetic wound healing . Nat Commun . 2021 ; 12 ( 1 ): 3363 .
Yang H , Wang W , Xiao J , Yang R , Feng L , Xu H , et al . ROS-responsive injectable hydrogels loaded with exosomes carrying miR-4500 reverse liver fibrosis . Biomaterials . 2025 ; 314 : 122887 .
Li H , Yuan Y , Zhang L , Xu C , Xu H , Chen Z . Reprogramming macrophage polarization, depleting ROS by astaxanthin and thioketal-containing polymers delivering rapamycin for osteoarthritis treatment . Adv Sci (Weinh) . 2024 ; 11 ( 9 ): e2305363 .
Pei P , Sun C , Tao W , Li J , Yang X , Wang J . ROS-sensitive thioketal-linked polyphosphoester-doxorubicin conjugate for precise phototriggered locoregional chemotherapy . Biomaterials 2019 ; 188 : 74 - 82 .
Criado-Gonzalez M , Mecerreyes D . Thioether-based ROS responsive polymers for biomedical applications . J Mater Chem B . 2022 ; 10 ( 37 ): 7206 - 21 .
Cao W , Gu Y , Li T , Xu H . Ultra-sensitive ROS-responsive tellurium-containing polymers . Chem Commun (Camb) . 2015 ; 51 ( 32 ): 7069 - 71 .
Gao J , Zhai Y , Lu W , Jiang X , Zhou J , Wu L , et al . ROS-sensitive PD-L1 siRNA cationic selenide nanogels for self-inhibition of autophagy and prevention of immune escape . Bioact Mater . 2024 ; 41 : 597 - 610 .
Kim KS , Lee D , Song CG , Kang PM . Reactive oxygen species-activated nanomaterials as theranostic agents . Nanomedicine (Lond) . 2015 ; 10 ( 17 ): 2709 - 23 .
Sheng Y , Zhang C , Cai D , Xu G , Chen S , Li W , et al . 2,2’,4,4’-Tetrabromodiphenyl ether and cadmium co-exposure activates aryl hydrocarbon receptor pathway to induce ROS and GSDME-dependent pyroptosis in renal tubular epithelial cells . Environ Toxicol . 2024 ; 39 ( 1 ): 289 - 98 .
Shi G , Wu Z , Hao Z , Zhu M , Shu F , Yang Z , et al . Microenvironment-responsive hydrogels comprising engineering zeolitic imidazolate framework-8-anchored parathyroid hormone-related peptide-1 for osteoarthritis therapy . ACS Nano . 2025 ; 19 ( 6 ): 6529 - 53 .
Yan J , Wang Y , Zhang J , Liu X , Yu L , He Z . Rapidly blocking the calcium overload/ROS production feedback loop to alleviate acute kidney injury via microenvironment-responsive BAPTA-AM/BAC co-delivery nanosystem . Small . 2023 ; 19 ( 17 ): e2206936 .
Zhang Y , Zhou X , Liang G , Cui M , Qiu Z , Xu J , et al . Iron-chelating and ROS-scavenging polymers with thioketal and thioether bonds delivering ferroptosis inhibitor lip-1 provide a triple therapeutic strategy for retina ganglion cells in acute glaucoma . Adv Mater . 2025 ; 37 ( 39 ): e2507526 .
Liu L , Wang W , Huang L , Xian Y , Ma W , Fan J , et al . Injectable pathological microenvironment-responsive anti-inflammatory hydrogels for ameliorating intervertebral disc degeneration . Biomaterials . 2024 ; 306 : 122509 .
Hu D , Li Y , Li R , Wang M , Zhou K , He C , et al . Recent advances in reactive oxygen species (ROS)-responsive drug delivery systems for photodynamic therapy of cancer . Acta Pharm Sin B . 2024 ; 14 ( 12 ): 5106 - 31 .
Fan K , Yang D , Zhu X , Zheng L , Han Y , Lin J , et al . High-efficiency antioxidant ROS-responsive thermosensitive hydrogel encapsulated Fenofibrate for the treatment of corneal neovascularization . J Control Release . 2025 ; 382 : 113650 .
Yu Y , Jiang X , Yu T , Chen F , Huang R , Xun Z , et al . Maintaining myoprotein and redox homeostasis via an orally recharged nanoparticulate supplement potentiates sarcopenia treatment . Biomaterials . 2025 ; 314 : 122863 .
Ahmed W , Li S , Liang M , Kang Y , Liu X , Gao C . Multifunctional drug- and AuNRs-loaded ROS-responsive selenium-containing polyurethane nanofibers for smart wound healing . ACS Biomater Sci Eng . 2024 ; 10 ( 6 ): 3946 - 57 .
Gao Y , Yang R , Shou Z , Zan X , Tang S . Optimization of boronic ester-based amphiphilic copolymers for ROS-responsive drug delivery . Chem Commun (Camb) . 2024 ; 60 ( 52 ): 6683 - 6 .
Song F , Li S , Sun C , Ji Y , Zhang Y . ROS-responsive selenium-containing carriers for coencapsulation of photosensitizer and hypoxia-activated prodrug and their cellular behaviors . Macromol Biosci . 2021 ; 21 ( 12 ): e2100229 .
Zhang Y , Liang Z , Tan Z , Lin J , Jiang X , Zhou X , et al . Bioinformatics-driven engineering of ROS-responsive dextran-block-poly(propylene sulfide) nanoparticles functionalized with folic acid for targeted prostate cancer therapy . ACS Omega . 2025 ; 10 ( 23 ): 24601 - 17 .
Xiong Y , Feng Q , Lu L , Qiu X , Knoedler S , Panayi AC , et al . Metal-organic frameworks and their composites for chronic wound healing: from bench to bedside . Adv Mater . 2024 ; 36 ( 2 ): e2302587 .
Wu Y , Wang Y , Long L , Hu C , Kong Q , Wang Y . A spatiotemporal release platform based on pH/ROS stimuli-responsive hydrogel in wound repairing . J Control Release . 2022 ; 341 : 147 - 65 .
Huang T , Yuan B , Jiang W , Ding Y , Jiang L , Ren H , et al . Glucose oxidase and Fe 3 O 4 /TiO 2 /Ag 3 PO 4 co-embedded biomimetic mineralization hydrogels as controllable ROS generators for accelerating diabetic wound healing . J Mater Chem B . 2021 ; 9 ( 31 ): 6190 - 200 .
Jeong SH , Cheong S , Kim TY , Choi H , Hahn SK . Supramolecular hydrogels for precisely controlled antimicrobial peptide delivery for diabetic wound healing . ACS Appl Mater Interfaces . 2023 ; 15 ( 13 ): 16471 - 81 .
Guo C , Wu Y , Li W , Wang Y , Kong Q . Development of a microenvironment-responsive hydrogel promoting chronically infected diabetic wound healing through sequential hemostatic, antibacterial, and angiogenic activities . ACS Appl Mater Interfaces . 2022 ; 14 ( 27 ): 30480 - 92 .
Shi R , Li H , Jin X , Huang X , Ou Z , Zhang X , et al . Promoting Re-epithelialization in an oxidative diabetic wound microenvironment using self-assembly of a ROS-responsive polymer and P311 peptide micelles . Acta Biomater . 2022 ; 152 : 425 - 39 .
Ma W , Zhang X , Liu Y , Fan L , Gan J , Liu W , et al . Polydopamine decorated microneedles with Fe-MSC-derived nanovesicles encapsulation for wound healing . Adv Sci (Weinh) . 2022 ; 9 ( 13 ): e2103317 .
Zhao M , Kang M , Wang J , Yang R , Zhong X , Xie Q , et al . Stem cell-derived nanovesicles embedded in dual-layered hydrogel for programmed ROS regulation and comprehensive tissue regeneration in burn wound healing . Adv Mater . 2024 ; 36 ( 32 ): e2401369 .
Chen Y , Lei K , Li Y , Mu Z , Chu T , Hu J , et al . Synergistic effects of NO/H 2 S gases on antibacterial, anti-inflammatory, and analgesic properties in oral ulcers using a gas-releasing nanoplatform . Acta Biomater . 2025 ; 194 : 288 - 304 .
Tu C , Lu H , Zhou T , Zhang W , Deng L , Cao W , et al . Promoting the healing of infected diabetic wound by an anti-bacterial and nanoenzyme-containing hydrogel with inflammation-suppressing, ROS-scavenging, oxygen and nitric oxide-generating properties . Biomaterials 2022 ; 286 : 121597 .
Tian S , Mei J , Zhang L , Wang S , Yuan Y , Li J , et al . Multifunctional hydrogel microneedle patches modulating oxi-inflamm-aging for diabetic wound healing . Small . 2024 ; 20 ( 51 ): e2407340 .
Xiao J , An X , Tang F , Dai X , Zhang S , Zhu X , et al . Photosynthesis-inspired NIR-triggered Fe 3 O 4 @MoS 2 core-shell nanozyme for promoting MRSA-infected diabe tic wound healing . Adv Healthc Mater . 2025 ; 14 ( 7 ): e2404525 .
Xiong Y , Chen, L , Liu, P , Yu, T , Lin, C , Yan, C , et al . All-in-one: multifunctional hydrogel accelerates oxidative diabetic wound healing through timed-release of exosome and fibroblast growth factor . Small . 2022 ; 18 ( 1 ): e2104229 .
Wu L , Lu Y , Liu L , Wang J , Bai Y , Song J , et al . BaTiO 3 doping enhances ultrasound-driven piezoelectric bactericidal effe cts of fibrous poly(L-lactic acid) dressings to accelerate septic wound healing . ACS Appl Mater Interfaces . 2024 ; 16 ( 49 ): 67477 - 90 .
Yang H , Lv D , Qu S , Xu H , Li S , Wang Z , et al . A ROS-responsive lipid nanoparticles release multifunctional hydrogel based on microenvironment regulation promotes infected diabetic wound healing . Adv Sci (Weinh) . 2024 ; 11 ( 43 ): e2403219 .
Huang ZJ , Ye MN , Peng XH , Gui P , Cheng F , Wang GH . Thiolated chitosan hydrogel combining nitric oxide and silver nanoparticles for the effective treatment of diabetic wound healing . Int J Biol Macromol . 2025 ; 311 ( Pt 4 ): 143730 .
Puertas-Bartolome M , Wlodarczyk-Biegun MK , Del Campo A , Vazquez-Lasa B , San Roman J . Development of bioactive catechol functionalized nanoparticles applicable for 3D bioprinting . Mater Sci Eng C Mater Biol Appl . 2021 ; 131 : 112515 .
Wu S , Zhang H , Wang S , Sun J , Hu Y , Liu H , et al . Ultrasound-triggered in situ gelation with ROS-controlled drug release for cartilage repair . Mater Horiz . 2023 ; 10 ( 9 ): 3507 - 22 .
Elbedwehy AM , Wu J , Na HK , Baek A , Jung H , Kwon IH , et al . ROS-responsive charge reversal mesoporous silica nanoparticles as promising drug delivery system for neovascular retinal diseases . J Control Release . 2024 ; 373 : 224 - 39 .
Li X , Li Y , Yu C , Bao H , Cheng S , Huang J , et al . ROS-responsive janus Au/mesoporous silica core/shell nanoparticles for drug delivery and long-term CT imaging tracking of MSCs in pulmonary fibrosis treatment . ACS Nano . 2023 ; 17 ( 7 ): 6387 - 99 .
Xiong Y , Mi B , Liu G , Zhao Y . Microenvironment-sensitive nanozymes for tissue regeneration . Biomaterials . 2024 ; 309 : 122585 .
Luo LJ , Nguyen DD , Lai JY . Harnessing the tunable cavity of nanoceria for enhancing Y-27632-mediated alleviation of ocular hypertension . Theranostics . 2021 ; 11 ( 11 ): 5447 - 63 .
Yang CJ , Nguyen DD , Lai JY . Poly(l-histidine)-mediated on-demand therapeutic delivery of roughened ceria nanocages for treatment of chemical eye injury . Adv Sci (Weinh) . 2023 ; 10 ( 26 ): e2302174 .
Li M , Tian J , Yu K , Liu H , Yu X , Wang N , et al . A ROS-responsive hydrogel incorporated with dental follicle stem cell-derived small extracellular vesicles promotes dental pulp repair by ameliorating oxidative stress . Bioact Mater . 2024 ; 36 : 524 - 40 .
Nguyen DD , Lai JY . Advancing the stimuli response of polymer-based drug delivery systems for ocular disease treatment . Polymer Chemistry . 2020 ; 11 ( 44 ): 6988 - 7008 .
Nguyen DD , Lai JY . Synthesis, bioactive properties, and biomedical applications of intrinsically therapeutic nanoparticles for disease treatment . Chem Eng J . 2022 ; 435 : 134970 .
Geng C , He S , Yu S , Johnson HM , Shi H , Chen Y , et al . Achieving clearance of drug-resistant bacterial infection and rapid cutaneous wound regeneration using an ROS-balancing-engineered heterojunction . Adv Mater . 2024 ; 36 ( 16 ): e2310599 .
Gu C , Fang S , Liu L , Chen B , Xu L , Shao M , et al . Local release of copper manganese oxide using HA microneedle for improving the efficacy of drug-resistant wound inflammation . Small . 2024 ; 20 ( 51 ): e2406377 .
Kang Y , Xu L , Dong J , Yuan X , Ye J , Fan Y , et al . Programmed microalgae-gel promotes chronic wound healing in diabetes . Nat Commun . 2024 ; 15 ( 1 ): 1042 .
Xiong R , Zhou M , Li H , Wang L , Ling G , Zhang P . The three-pronged strategy: a bilayer hydrogel treats diabetic chronic wound through microalgae oxygen therapy, Ag horizontal line FA NP antibacterial, and synergistic scavenging of ROS . Small . 2025 ; 21 ( 30 ): e2502205 .
Zhang X , Ren K , Xiao C , Chen X . Guanosine-driven hyaluronic acid-based supramolecular hydrogels with peroxidase-like activity for chronic diabetic wound treatment . Acta Biomater . 2023 ; 172 : 206 - 17 .
Pang Y , Amona FM , Chen X , You Y , Sha Z , Liu Z , et al . Phytochemical nanozymes reprogram redox for balanced antimicrobial and regenerative therapy in acute and chronic diabetic wounds . Redox Biol . 2025 ; 85 : 103718 .
Zhao A , Sun J , Liu Y . Understanding bacterial biofilms: from definition to treatment strategies . Front Cell Infect Microbiol . 2023 ; 13 : 1137947 .
Liu GY , Yu D , Fan MM , Zhang X , Jin ZY , Tang C , et al . Antimicrobial resistance crisis: could artificial intelligence be the solution? . Mil Med Res . 2024 ; 11 ( 1 ): 7 .
Li YJ , Wei SC , Chu HW , Jian HJ , Anand A , Nain A , et al . Polyquercetin-based nanoVelcro as a multifunctional wound dressing for effective treatment of chronic wound infections . Chem Eng J . 2022 ; 437 : 135315 .
Zha K , Xiong Y , Zhang W , Tan M , Hu W , Lin Z , et al . Waste to wealth: near-infrared/pH dual-responsive copper-humic acid hydrogel films for bacteria-infected cutaneous wound healing . ACS Nano . 2023 ; 17 ( 17 ): 17199 - 216 .
Li J , Wang M , Tan X , Duanmiao Y , Zheng X , Wang Z , et al . A dual-component particulate dressing for simultaneous microenvironment modulation and tissue regeneration in infected diabetic wounds . Mater Today Bio . 2025 ; 33 : 102005 .
Li Y , Wang Y , Ding Y , Fan X , Ye L , Pan Q , et al . A double network composite hydrogel with self-regulating Cu 2+ /luteolin release and mechanical modulation for enhanced wound healing . ACS Nano . 2024 ; 18 ( 26 ): 17251 - 66 .
Nie R , Zhang J , Jia Q , Li Y , Tao W , Qin G , et al . Structurally oriented carbon dots as ROS nanomodulators for dynamic chronic inflammation and infection elimination . ACS Nano . 2024 ; 18 ( 33 ): 22055 - 70 .
Zhang, W , Zha, K , Xiong, Y , Hu, W , Chen, L , Lin, Z , et al . Glucose-responsive, antioxidative HA-PBA-FA/EN106 hydrogel enhanced diabetic wound healing through modulation of FEM1b-FNIP1 axis and promoting angiogenesis . Bioact Mater 2023 ; 30 : 29 - 45 .
Zhang Z , Zhang Y , Peng L , Xing Y , Zhou X , Zheng S , et al . Multifunctional dual-layer microneedles loaded with selenium-doped carbon quantum dots and Astilbin for ameliorating diabetic wound healing . Mater Today Bio . 2025 ; 32 : 101739 .
Li H , Wen H , Zhang H , Cao X , Li L , Hu X , et al . A multifunctional dihydromyricetin-loaded hydrogel for the sequential modulation of diabetic wound healing and glycemic control . Burns Trauma . 2025 ; 13 : tkaf024 .
Huang K , Mi B , Xiong Y , Fu Z , Zhou W , Liu W , et al . Angiogenesis during diabetic wound repair: from mechanism to therapy opportunity . Burns Trauma . 2025 ; 13 : tkae052 .
Kuan CH , Chang L , Ho CY , Tsai CH , Liu YC , Huang WY , et al . Immunomodulatory hydrogel orchestrates pro-regenerative response of macrophages and angiogenesis for chronic wound healing . Biomaterials . 2025 ; 314 : 122848 .
He F , Xu P , Zhu Z , Zhang Y , Cai C , Zhang Y , et al . Inflammation-responsive hydrogel accelerates diabetic wound healing through immunoregulation and enhanced angiogenesis . Adv Healthc Mater . 2025 ; 14 ( 5 ): e2400150 .
Wang M , Chen J , Luo Y , Feng M , Yang Q , Tang Y , et al . Design strategies and application potential of multifunctional hydrogels for promoting angiogenesis . Int J Nanomedicine . 2024 ; 19 : 12719 - 42 .
Xiang P , Jiang M , Chen X , Chen L , Cheng Y , Luo X , et al . Targeting grancalcin accelerates wound healing by improving angiogenesis in diabetes . Adv Sci (Weinh) . 2024 ; 11 ( 14 ): e2305856 .
Guan Y , Niu H , Liu Z , Dang Y , Shen J , Zayed M , et al . Sustained oxygenation accelerates diabetic wound healing by promoting epithelialization and angiogenesis and decreasing inflammation . Sci Adv . 2021 ; 7 ( 35 ): abj0153 .
Wang J , Li X , Zhao X , Yuan S , Dou H , Cheng T , et al . Lactobacillus rhamnosus GG-derived extracellular vesicles promote wound healing via miR-21-5p-mediated re-epithelization and angiogenesis . J Nanobiotechnology . 2024 ; 22 ( 1 ): 644 .
Wang K , He Q , Yang M , Qiao Q , Chen J , Song J , et al . Glycoengineered extracellular vesicles released from antibacterial hydrogel facilitate diabetic wound healing by promoting angiogenesis . J Extracell Vesicles . 2024 ; 13 ( 11 ): e70013 .
Zeng R , Xiong Y , Lin Z , Chu X , Lv B , Lu L , et al . Novel cocktail therapy based on multifunctional supramolecular hydrogel targeting immune-angiogenesis-nerve network for enhanced diabetic wound healing . J Nanobiotechnology . 2024 ; 22 ( 1 ): 749 .
Chen S , Chen J , Wang X , Yang Z , Lan J , Wang L , et al . Glucose-activated self-cascade antibacterial and pro-angiogenesis nanozyme-functionalized chitosan-arginine thermosensitive hydrogel for chronic diabetic wounds healing . Carbohydr Polym 2025 ; 348 ( Pt B ): 122894 .
Li F , Du Y , Zheng Y , Liu Y , Zhu X , Cui Y , et al . Microenvironment-responsive MOF nanozymes armored cryogels promoted wound healing via rapid hemostasis, infection elimination and angiogenesis . J Control Release . 2025 ; 384 : 113838 .
Tian X , Wen Y , Zhang Z , Zhou K , Shang L , Zhu J , et al . Smart multifunctional ROS-responsive supramolecular hydrogel for simultaneously regulating oxidative stress, immune dysregulation, and bacterial infection in diabetic wound healing . Biomaterials 2026 ; 330 : 124006 .
Huang K , Liu W , Wei W , Zhao Y , Zhuang P , Wang X , et al . Photothermal hydrogel encapsulating intelligently bacteria-capturing Bio-MOF for infectious wound healing . ACS Nano . 2022 ; 16 ( 11 ): 19491 - 508 .
Liu WS , Lu ZM , Pu XH , Li XY , Zhang HQ , Zhang ZZ , et al . A dendritic cell-recruiting, antimicrobial blood clot hydrogel for melanoma recurrence prevention and infected wound management . Biomaterials . 2025 ; 313 : 122776 .
Wu Z , Chang L , Li C , Xu P , Liu L , Tong A , et al . Prodigiosin loaded SN-PB@PG NPs-based multimodal therapy for the healing of bacterial infected chronic wounds . Adv Healthc Mater . 2025 ; 14 ( 12 ): e2405100 .
Zhang R , Wang S , Ma X , Jiang S , Chen T , Du Y , et al . In situ gelation strategy based on ferrocene-hyaluronic acid organic copolymer biomaterial for exudate management and multi-modal wound healing . Acta Biomater 2022 ; 154 : 180 - 93 .
Li H , Feng Y , Lin B , Zhang S , Ren Y , Yue J . Polyurea-based multimodal interaction nanogels for synergistic bacterial biofilm eradication and prevention of re-colonization . Biomaterials . 2026 ; 325 : 123607 .
Wu J , Wu Y , Tang H , Li W , Zhao Z , Shi X , et al . Self-adapting biomass hydrogel embodied with miRNA immunoregulation and long-term bacterial eradiation for synergistic chronic wound therapy . ACS Nano . 2024 ; 18 ( 28 ): 18379 - 92 .
Liu J , Han X , Zhang T , Tian K , Li Z , Luo F . Reactive oxygen species (ROS) scavenging biomaterials for anti-inflammatory diseases: from mechanism to therapy . J Hematol Oncol . 2023 ; 16 ( 1 ): 116 .
Cao W , Peng S , Yao Y , Xie J , Li S , Tu C , et al . A nanofibrous membrane loaded with doxycycline and printed with conductive hydrogel strips promotes diabetic wound healing in vivo . Acta Biomater . 2022 ; 152 : 60 - 73 .
Shen J , Tong Z , Han B , Zhang Z , Xian Z , Yuan Y , et al . Synergistic wound healing: unraveling the multi-target effects of traditional Chinese medicine and its biomaterials on chronic wound pathways . Int J Nanomedicine 2025 ; 20 : 12889 - 912 .
Horta-Velazquez A , Mota-Morales JD , Morales-Narvaez E . Next-generation of smart dressings: integrating multiplexed sensors and theranostic functions . Int J Biol Macromol . 2024 ; 254 ( Pt 1 ): 127737 .
Burkett BJ , Bartlett DJ , McGarrah PW , Lewis AR , Johnson DR , Berberoglu K , et al . A review of theranostics: perspectives on emerging approaches and clinical advancements . Radiol Imaging Cancer . 2023 ; 5 ( 4 ): e220157 .
Duan W , Zhao J , Liu X , Zheng Y , Wu J . Trapping and release of NIR-active dye in porous silicon as a theranostic strategy for ROS photothermal monitoring and chronic wound management . J Control Release . 2023 ; 359 : 428 - 40 .
Joorabloo A , Liu T . Smart theranostics for wound monitoring and therapy . Adv Colloid Interface Sci . 2024 ; 330 : 103207 .
Chen Y , Yang X , Li K , Feng J , Liu X , Li Y , et al . Phenolic ligand-metal charge transfer induced copper nanozyme with reactive oxygen species-scavenging ability for chronic wound healing . ACS Nano . 2024 ; 18 ( 9 ): 7024 - 36 .
Zhao Y , Zhao Y , Xu B , Liu H , Chang Q . Microenvironmental dynamics of diabetic wounds and insights for hydrogel-based therapeutics . J Tissue Eng . 2024 ; 15 : 20417314241253290 .
Wang S , Zhang Y , Zhong Y , Xue Y , Liu Z , Wang C , et al . Accelerating diabetic wound healing by ROS-scavenging lipid nanoparticle-mRNA formulation . Proc Natl Acad Sci U S A . 2024 ; 121 ( 22 ): e2322935121 .
Gumede DB , Abrahamse H , Houreld NN . Targeting Wnt/β-catenin signaling and its interplay with TGF-β and Notch signaling pathways for the treatment of chronic wounds . Cell Commun Signal . 2024 ; 22 ( 1 ): 244 .
Stewart DC , Brisson BK , Yen WK , Liu Y , Wang C , Ruthel G , et al . Type Ⅲ collagen regulates matrix architecture and mechanosensing during wound healing . J Invest Dermatol . 2025 ; 145 ( 4 ): 919 - 38.e14 .
He J , Cheng X , Fang B , Shan S , Li Q . Mechanical stiffness promotes skin fibrosis via Piezo1-Wnt2/Wnt11-CCL24 positive feedback loop . Cell Death Dis . 2024 ; 15 ( 1 ): 84 .
Patil P , Russo KA , McCune JT , Pollins AC , Cottam MA , Dollinger BR , et al . Reactive oxygen species-degradable polythioketal urethane foam dressings to promote porcine skin wound repair . Sci Transl Med . 2022 ; 14 ( 641 ): eabm6586 .
Sabio L , Day GJ , Salmeron-Sanchez M . Probiotic-based materials as living therapeutics . Adv Mater . 2026 ; 38 ( 1 ): e08500 .
Alam A , Kumar A , Jiji S , Akhila K , Khandelwal M . Integrating life into material design for living materials 4.0: navigating challenges and future trajectories from static to dynamic evolution . Materials Today . 2025 ; 90 : 385 - 410 .
Liu Y , Yang M , Li Y , Liu Y , Su H , Zhang W , et al . A multifunctional living hydrogel for the synergistic management of infected diabetic wounds . Mater Today Bio . 2025 ; 32 : 101787 .
Toprak, B , Kalaycioglu, GD , Aydogan, N . Multifunctional CD-MOF hybrid systems: integrating drug delivery, photothermal therapy, and nanozyme applications . Small . 2025 ; e05408 .
Yayun, J , Qianqian, G , Xihang, S , Yang, H , Zhenping, H , Yuying, L , et al . Metal-organic framework-mediated antioxidant enzyme delivery in disease treatment . Redox Biol . 2025 ; 85 : 103778 .
Cheng Q , Cheng C , Xu L . Polysaccharide-silane polymer composites: a novel electrically tunable drug delivery platform for polycystic ovary syndrome treatment . Carbohydr Res . 2025 ; 557 : 109645 .
Tong M , Kuang X , Jiang Q , Li G , Jin L , Ye Y , et al . Spore-inspired inhalation drug delivery system for asthma therapy . Bioact Mater . 2025 ; 53 : 801 - 18 .
Wang Y , Sun D , Laney V , Wang H , Wang LL , Lu ZR . Challenges and opportunities on achieving an adequate delivery efficiency and immunogenicity with peptide-based anticancer vaccines . Adv Drug Deliv Rev . 2025 ; 225 : 115675 .
Cheng P , Xie X , Hu L , Zhou W , Mi B , Xiong Y , et al . Hypoxia endothelial cells-derived exosomes facilitate diabetic wound healing through improving endothelial cell function and promoting M2 macrophages polarization . Bioact Mater . 2024 ; 33 : 157 - 73 .
Li Z , Mao K , Yue M , Liu Y , Fan K . Nanozymes in oral medicine: from catalytic design to advanced dental therapies . Small . 2025 ; 21 ( 38 ): e07226 .
Yang Z , Qin R , Ruan D , Hu C , Li W , Zhou J , et al . Ce6-DNAzyme-loaded metal-organic framework theranostic agents for boosting miRNA imaging-guided photodynamic therapy in breast cancer . ACS Nano . 2025 ; 19 ( 30 ): 27873 - 89 .
Wang Z , Zeng X , Feng W , Lu Y , Wei P . Reframing chronic wound therapy: from growth factor delivery to regenerative immunoengineering . Front Immunol 2025 ; 16 : 1683591 .
Saeed S , Martins-Green M . Assessing animal models to study impaired and chronic wounds . Int J Mol Sci . 2024 ; 25 ( 7 ): ijms25073837 .
Lou J , Xiang Z , Zhu X , Li J , Jin G , Cui S , et al . Skin microbiota and diabetic foot ulcers . Front Microbiol . 2025 ; 16 : 1575081 .
Chen M , Liu D , Liu F , Wu Y , Peng X , Song F . Recent advances of redox-responsive nanoplatforms for tumor theranostics . J Control Release . 2021 ; 332 : 269 - 84 .
Li Q , Li J , Song S , Chen W , Shen X , Li S , et al . Nanoparticle-mediated tumor vaccines for personalized therapy: preparing tumor antigens in vivo or ex vivo ? . J Mater Chem B . 2021 ; 9 ( 10 ): 2352 - 66 .
Wang Y , Su P , Lin Z , Li X , Chen K , Ye T , et al . A tribo/piezoelectric nanogenerator based on Bio-MOFs for energy harvesting and antibacterial wearable device . Adv Mater . 2025 ; 37 ( 9 ): e2418207 .
Gong J , Ye C , Ran J , Xiong X , Fang X , Zhou X , et al . Polydopamine-mediated immunomodulatory patch for diabetic periodontal tissue regeneration assisted by metformin-ZIF system . ACS Nano . 2023 ; 17 ( 17 ): 16573 - 86 .
Song J , Cheng M , Xie Y , Li K , Zang X . Efficient tumor synergistic chemoimmunotherapy by self-augmented ROS-responsive immunomodulatory polymeric nanodrug . J Nanobiotechnology . 2023 ; 21 ( 1 ): 93 .
Yang L , Zhang D , Li W , Lin H , Ding C , Liu Q , et al . Biofilm microenvironment triggered self-enhancing photodynamic immunomodulatory microneedle for diabetic wound therapy . Nat Commun . 2023 ; 14 ( 1 ): 7658 .
Zhou H , Liao Y , Han X , Chen DS , Hong X , Zhou K , et al . ROS-responsive nanoparticle delivery of mRNA and photosensitizer for combinatorial cancer therapy . Nano Lett . 2023 ; 23 ( 9 ): 3661 - 8 .
0
Views
0
Downloads
0
CSCD
Publicity Resources
Related Articles
Related Author
Related Institution
京公网安备11010802024621