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Dual-locked targeted alpha-emitter enhanced tumor immunotherapy via Diels–Alder reaction-based self-immolative molecular cage strategy
RESEARCH | 更新时间：2026-06-10
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    • Dual-locked targeted alpha-emitter enhanced tumor immunotherapy via Diels–Alder reaction-based self-immolative molecular cage strategy

    • Dual-locked targeted alpha-emitter enhanced tumor immunotherapy via Diels–Alder reaction-based self-immolative molecular cage strategy

    • “研究人员开发了一种双锁定预靶向策略，将负载铂的水凝胶纳米颗粒和负载镭-223的纳米颗粒整合到反向电子需求Diels-Alder激活的药物递送系统中，该系统为解决靶向α治疗中放射性核素泄漏的关键挑战提供了解决方案，并为构建下一代精确靶向放射性药物奠定了基础。”
    • Meng-Die Yang ，Kang Fang ，Xiao-Yi Zhang ，Gang Yang ，He-Qing Yi ，Le Cai ，Shan-Shan Qin ，Xin-Da Yang ，Rong Rong ，Shuo Shi ，Fei Yu
    • Military Medical Research 2026年13卷第5期 页码：728-746

    • DOI： 10.1186/s40779-025-00673-5     

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    • 录用：2025-11-13 ，

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