β-catenin initiates peritoneal fibrosis by triggering mitochondrial fission-mediated mesothelial cell senescence fate transition

Xiao-Xu Wang; Wei-Jie Zhong; Jie-Mei Li; Di Wang; Shuang-Qin Chen; Jin-Hua Miao; Wei-Wei Shen; Xiao-Long Li; Jie-Wu Huang; Shan Zhou; Cheng Wang; Jun Ai; Li-Li Zhou

doi:10.1186/s40779-025-00669-1

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β-catenin initiates peritoneal fibrosis by triggering mitochondrial fission-mediated mesothelial cell senescence fate transition

RESEARCH | 更新时间：2026-08-20

- β-catenin initiates peritoneal fibrosis by triggering mitochondrial fission-mediated mesothelial cell senescence fate transition
- β-catenin initiates peritoneal fibrosis by triggering mitochondrial fission-mediated mesothelial cell senescence fate transition
- Xiao-Xu Wang ，Wei-Jie Zhong ，Jie-Mei Li ，Di Wang ，Shuang-Qin Chen ，Jin-Hua Miao ，Wei-Wei Shen ，Xiao-Long Li ，Jie-Wu Huang ，Shan Zhou ，Cheng Wang ，Jun Ai ，Li-Li Zhou
- Military Medical Research 2026年13卷第6期页码：894-915
- 作者机构：
  Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
  State Key Laboratory of Multi-Organ Injury Prevention and Treatment, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
  National Clinical Research Center for Kidney Disease, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
  Guangdong Provincial Institute of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
  Guangdong Provincial Key Laboratory of Renal Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
  Division of Nephrology, Department of Medicine, the Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai 519000, Guangdong, China
- 作者简介：
  * Cheng Wang wangch2@mail.sysu.edu.cn
  Jun Ai aij1980@smu.edu.cn
  Li-Li Zhou jinli730@smu.edu.cn
- 基金信息：
  the National Natural Science Foundation of China(82225010;82370744;82400881);the Guangdong Basic and Applied Basic Research Foundation(2023A1515110906);the Postdoctoral Science Foundation of China(2023M731558);the Postdoctoral Fellowship Program of China Postdoctoral Science Foundation(GZC20231060)
- DOI： 10.1186/s40779-025-00669-1
  中图分类号：
- 录用：2025-11-03 ，
- 稿件说明：
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