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Cell-free DNA in sepsis: from molecular insights to clinical management
Cell-free DNA in sepsis: from molecular insights to clinical management
Cell-free DNA in sepsis: from molecular insights to clinical management
- “无细胞DNA作为脓毒症治疗的有前景的生物标志物和治疗靶点,介绍了其在临床诊断和治疗领域的研究进展。研究人员建立了cfDNA释放机制系统,并通过TLR9、AIM2和cGAS STING途径探索了其病理作用,为解决败血症相关器官功能障碍问题提供了解决方案,并为构建包括PAD4抑制剂和DNases在内的靶向治疗策略奠定了基础。”
- Military Medical Research 2026年13卷第5期 页码:766-810
DOI: 10.1186/s40779-025-00668-2
录用:2025-11-01
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相关作者
Shao-Yu Liu
Shao-Kang Xu
Jing-Li Gao
Xiao-Ke Kong
Jian Shi
Ya Miao
Yi-Ting Tang
Bin Zhao
相关机构
Department of Critical Care Medicine and Hematology, the Second Xiangya Hospital, Central South University
Department of Critical Care Medicine and Hematology, the Third Xiangya Hospital, Central South University
Department of Intensive Medicine, Kailuan General Hospital
National Clinical Research Center for Endocrine and Metabolic Diseases, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology, Ministry of Education, and Department of Metabolism and Endocrinology, the Second Xiangya Hospital of Central South University
CSU-Sinocare Research Center for Nutrition and Metabolic Health, Xiangya School of Public Health, Central South University; Furong Laboratory

