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TNC-targeted CAR-macrophage therapy alleviates liver fibrosis in mice
RESEARCH | 更新时间：2026-06-10
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    • TNC-targeted CAR-macrophage therapy alleviates liver fibrosis in mice

    • TNC-targeted CAR-macrophage therapy alleviates liver fibrosis in mice

    • “一个研究小组介绍了其在肝纤维化治疗方面的进展。他们设计了TNC靶向的CAR巨噬细胞，验证了它们吞噬活化的肝星状细胞并通过TLR4/NF-κB和整合素/FAK途径减少纤维化的能力，这为肝病治疗提供了解决方案。”
    • Kai-Zhao Chen ，Zi-Yang Lin ，Long-Jun Chen ，You-Xi Zhou ，Wei Zhang ，Hao-Yang Wan ，Yong-Kun Huo ，Qi Fu ，Zi-Qing Gao ，Hong-Wei Cheng ，Xiao-Dong Ma ，Shuai-Shuai Zhang
    • Military Medical Research 2026年13卷第5期 页码：706-727

    • DOI： 10.1186/s40779-025-00667-3     

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    • 录用：2025-10-31 ，

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相关作者

Xiu-Wen Wu
Li-Ting Deng
Huan Yang
Xu-Fei Zhang
Ni Kuang
Jian-An Ren
Yun Zhao
Ye-Ting Zhu

相关机构

Nanjing Medical Key Laboratory of Laryngopharynx-Head and Neck Oncology, the Affiliated BenQ Hospital of Nanjing Medical University
Nanjing Medical University
Department of Emergency Surgery, the Affiliated Hospital of Qingdao University
Department of Infectious Diseases, Chongqing Key Laboratory for Research of Infectious Diseases, Southwest Hospital, Army Medical University
Department of General Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University