Ex-vivo limb perfusion in military and civilian medicine: inspired by ex-vivo organ perfusion, pioneered for traumatic limb amputation and peripheral nerve regeneration

Kirsten Haastert-Talini; Katherina Katsirntaki; Svenja Kankowski; Alexander Kaltenborn; Falk von Lübken; Christine Falk; Christopher Werlein; Danny Jonigk; Arjang Ruhparwar; Bettina Wiegmann

doi:10.1186/s40779-025-00656-6

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Ex-vivo limb perfusion in military and civilian medicine: inspired by ex-vivo organ perfusion, pioneered for traumatic limb amputation and peripheral nerve regeneration

RESEARCH | 更新时间：2026-06-10

- Ex-vivo limb perfusion in military and civilian medicine: inspired by ex-vivo organ perfusion, pioneered for traumatic limb amputation and peripheral nerve regeneration
- Ex-vivo limb perfusion in military and civilian medicine: inspired by ex-vivo organ perfusion, pioneered for traumatic limb amputation and peripheral nerve regeneration
- “研究人员开发了一种离体肢体灌注系统，延长了再植的肢体存活率，为沃勒变性建立了一个促再生环境，同时省略了抗炎性甲基强的松龙，增强了神经再生潜力，为构建改进的截肢护理系统奠定了基础。”
- Kirsten Haastert-Talini ，Katherina Katsirntaki ，Svenja Kankowski ，Alexander Kaltenborn ，Falk von Lübken ，Christine Falk ，Christopher Werlein ，Danny Jonigk ，Arjang Ruhparwar ，Bettina Wiegmann
- Military Medical Research 2026年13卷第4期页码：588-605
- 作者机构：
  1.Hannover Medical School, Institute of Neuroanatomy and Cell Biology, 30625 Hannover, Germany
  2.Center for Systems Neuroscience (ZSN), 30625 Hannover, Germany
  3.Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, 30625 Hannover, Germany
  4.Lower Saxony Center for Biomedical Engineering, Implant Research and Development (NIFE), 30625 Hannover, Germany
  5.Department of Trauma and Orthopedic Surgery, Plastic, Hand and Reconstructive Surgery, Armed Forces Hospital Westerstede, 26655 Westerstede, Germany
  6.Hannover Medi-cal School, Institute of Transplant Immunology, 30625 Hannover, Germany
  7.German Center for Lung Research (DZL), BREATH Hannover, 30625 Hannover, Germany
  8.Aachen University Medical Center, Institute of Pathology, RWTH Aachen University, 52074 Aachen, Germany
  9.Hannover Medical School, Institute of Pathology, 30625 Hannover, Germany
- 作者简介：
  * Bettina Wiegmann Wiegmann.Bettina@mh-hannover.de
- 基金信息：
  the German Armed Forces(E/U2ED/LD008/KF558);the German Research Foundation(DFGSPP2014: 347346497;447746988;347368182;KFO311 unloading & repair: 286251789)
- DOI： 10.1186/s40779-025-00656-6
  中图分类号：
- 录用：2025-09-28 ，
- 稿件说明：
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Ex-vivo limb perfusion in military and civilian medicine: inspired by ex-vivo organ perfusion, pioneered for traumatic limb amputation and peripheral nerve regeneration

Ex-vivo limb perfusion in military and civilian medicine: inspired by ex-vivo organ perfusion, pioneered for traumatic limb amputation and peripheral nerve regeneration

DOI： 10.1186/s40779-025-00656-6

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