Dual character of surface engineering on SN38 prodrug nano-assemblies: divergent effects on in vitro and in vivo behavior

Ya-Qiao Li; Zhi-Yu Kuang; Bao-Yuan Zhang; Yan-Zhong Hao; Ling-Xiao Li; Jing-Xuan Zhang; Ya-Fan Xiao; Bo-Wen Zhang; Xian-Bao Shi; Xiao-Hui Pu; Zhong-Gui He; Bing-Jun Sun

doi:10.1186/s40779-025-00648-6

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Dual character of surface engineering on SN38 prodrug nano-assemblies: divergent effects on in vitro and in vivo behavior

RESEARCH | 更新时间：2026-05-08

- Dual character of surface engineering on SN38 prodrug nano-assemblies: divergent effects on in vitro and in vivo behavior
- Dual character of surface engineering on SN38 prodrug nano-assemblies: divergent effects on in vitro and in vivo behavior
- Ya-Qiao Li ，Zhi-Yu Kuang ，Bao-Yuan Zhang ，Yan-Zhong Hao ，Ling-Xiao Li ，Jing-Xuan Zhang ，Ya-Fan Xiao ，Bo-Wen Zhang ，Xian-Bao Shi ，Xiao-Hui Pu ，Zhong-Gui He ，Bing-Jun Sun
- Military Medical Research 2026年13卷第3期页码：385-399
- 作者机构：
  1.Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China
  2.Department of Bioengineering, Graduate School of Engineering, the University of Tokyo, Tokyo 113-0033, Japan
  3.Department of Pharmacy, the First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121001, Liaoning, China
  4.State Key Laboratory of Antiviral Drugs, School of Pharmacy, Henan University, Kaifeng 475004, Henan, China
  5.Joint International Research Laboratory of Intelligent Drug Delivery Systems, Ministry of Education, Shenyang 110016, China
- 作者简介：
  * Zhong-Gui He hezhonggui@syphu.edu.cn
  Bing-Jun Sun sunbingjun@syphu.edu.cn
- 基金信息：
  the National Key R&D Program of China(2022YFE0111600);the National Natural Science Foundation of China(82204318);the Youth Innovation Team of Liaoning Province Department of Education(LJ222410163049);the Shenyang Young and Middle-aged Science and Technology Innovation Talent Support Program(RC220389);the Liaoning Revitalization Talents Program(XLYC2203083);Blood analyses were performed at Shenyang Companion Animal Hospital
- DOI： 10.1186/s40779-025-00648-6
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- 录用：2025-09-08 ，
- 稿件说明：
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