Clinical-transcriptomic classification of lumbar disc degeneration enhanced by machine learning

Huai-Jian Jin; Peng Lin; Xiao-Yuan Ma; Sha Huang; Liang Zhang; Ou Hu; Yang-Yang Li; Ying-Bo Wang; Jun Zhu; Bo Hu; Jun-Gang Pu; Qin Qin; Pu-Lin Yan; Bing Liu; Yu Lan; Lin Chen; Yang-Li Xie; Jian He; Yi-Bo Gan; Peng Liu

doi:10.1186/s40779-025-00637-9

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Clinical-transcriptomic classification of lumbar disc degeneration enhanced by machine learning

RESEARCH | 更新时间：2026-03-26

- Clinical-transcriptomic classification of lumbar disc degeneration enhanced by machine learning
- Clinical-transcriptomic classification of lumbar disc degeneration enhanced by machine learning
- “一项新的研究介绍了腰椎间盘退变（LDD）领域的重要研究进展。专家利用临床特征确定了四种不同的LDD分子亚型。这一突破可能有助于精确诊断，并指导LDD的个性化治疗策略。”
- Huai-Jian Jin ，Peng Lin ，Xiao-Yuan Ma ，Sha Huang ，Liang Zhang ，Ou Hu ，Yang-Yang Li ，Ying-Bo Wang ，Jun Zhu ，Bo Hu ，Jun-Gang Pu ，Qin Qin ，Pu-Lin Yan ，Bing Liu ，Yu Lan ，Lin Chen ，Yang-Li Xie ，Jian He ，Yi-Bo Gan ，Peng Liu
- Military Medical Research 2026年13卷第1期页码：58-77
- 作者机构：
  1.Department of Spine Surgery, Center of Orthopedics, State Key Laboratory of Trauma and Chemical Poisoning, Army Medical Center of PLA (Daping Hospital), Army Medical University, Chongqing 400042, China
  2.Department of Wound Infection and Drug, State Key Laboratory of Trauma and Chemical Poisoning, Army Medical Center of PLA (Daping Hospital), Army Medical University, Chongqing 400042, China
  3.Pain Department, Army Medical Center of PLA (Daping Hospital), Army Medical University, Chongqing 400042, China
  4.State Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Senior Department of Hematology, Fifth Medical Center, Medical Innovation Research Department, Chinese PLA General Hospital, Beijing 100071, China
  5.State Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Key Laboratory for Regenerative Medicine of Ministry of Education, Institute of Hematology, School of Medicine, Jinan University, Guangzhou 510632, China
  6.Center of Bone Metabolism and Repair, State Key Laboratory of Trauma and Chemical Poisoning, Trauma Center, Research Institute of Surgery, Laboratory for the Prevention and Rehabilitation of Military Training Related Injuries, Army Medical Center of PLA (Daping Hospital), Army Medical University, Chongqing 400042, China
  7.Tissue Stress Injury and Functional Repair Key Laboratory of Sichuan Province, The General Hospital of Western Theater Command, Chengdu 610031, China
- 作者简介：
  * Jian He jianhe.amms@gmail.com
  Yi-Bo Gan ganyibo@tmmu.edu.cn
  Peng Liu liupengd@tmmu.edu.cn
- 基金信息：
  the National Natural Science Foundation of China(32270887;82272507;32200654;82430079;82472519);the National Key Research and Development Program of China(2022YFA1103202);the Chongqing High-End Medical Talents for Middle-aged and Young(YXGD202408);the Army Scientific and Technological Innovation Talents Prioritized Support Program(2023-124);the Natural Science Foundation of Chongqing(CSTB2023NSCQ-ZDJO008);the Postdoctoral Innovative Talent Support Program(BX20220397);the Open Project of State Key Laboratory of Trauma, Burns and Combined Injury(SFLKF202201);the Project for Enhancing Innovation of Army Medical University(2023XJS39);the Talent Innovation Training Program at the Army Medical Center(ZXZYTSYS09)
- DOI： 10.1186/s40779-025-00637-9
  中图分类号：
- 录用：2025-07-26 ，
- 稿件说明：
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Clinical-transcriptomic classification of lumbar disc degeneration enhanced by machine learning

Clinical-transcriptomic classification of lumbar disc degeneration enhanced by machine learning

DOI： 10.1186/s40779-025-00637-9

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