Substantia nigra related gene polymorphisms associated with antipsychotic-induced acute movement disorders: a genome-wide association study and multi-ancestry validation in schizophrenia

Zhe Lu; Yao-Yao Sun; Zhe-Wei Kang; Guo-Rui Zhao; Yu-Yanan Zhang; Jun-Yuan Sun; Rui Yuan; Wei-Hua Yue

doi:10.1186/s40779-025-00636-w

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Substantia nigra related gene polymorphisms associated with antipsychotic-induced acute movement disorders: a genome-wide association study and multi-ancestry validation in schizophrenia

RESEARCH | 更新时间：2026-03-26

- Substantia nigra related gene polymorphisms associated with antipsychotic-induced acute movement disorders: a genome-wide association study and multi-ancestry validation in schizophrenia
- Substantia nigra related gene polymorphisms associated with antipsychotic-induced acute movement disorders: a genome-wide association study and multi-ancestry validation in schizophrenia
- “一项新的研究介绍了抗精神病药物诱导的运动障碍（AIMD）领域的研究进展。专家们在多个队列中进行了全基因组关联研究（GWAS），确定了与AIMD相关的关键遗传位点。这些发现强调了黑质相关基因多态性在AIMD中的作用，为精神分裂症的个性化治疗方法开辟了新的方向。”
- Zhe Lu ，Yao-Yao Sun ，Zhe-Wei Kang ，Guo-Rui Zhao ，Yu-Yanan Zhang ，Jun-Yuan Sun ，Rui Yuan ，Wei-Hua Yue
- Military Medical Research 2026年13卷第2期页码：185-197
- 作者机构：
  1.Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University Sixth Hospital, Beijing 100191, China
  2.PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China
  3.Chinese Institute for Brain Research, Beijing 102206, China
- 作者简介：
  * Yao-Yao Sun sunyaoyao@bjmu.edu.cn
  Wei-Hua Yue dryue@bjmu.edu.cn
- 基金信息：
  the National Natural Science Foundation of China(82330042;82441005;82301687);the National Key R& D Program of China(2023YFE0119400);the Capital’s Funds for Health Improvement and Research(2024-1-4111);the STI2030-Major Projects-2021ZD0200702, Fundamental Research Funds for the Central Universities (Peking University Medicine Fund for world’s leading discipline or discipline cluster development(BMU2022DJXK007);the Beijing Municipal Health Commission Research Ward Programme (3rd batch) , Beijing Nova Program(20230484425);the Beijing Municipal Science & Technology Commission, Administrative Commission of Zhongguancun Science Park(Z221100003522010);the China Postdoctoral Science Foundation(2024M760141;2022M720302);the National Postdoctoral Program for Innovative Talents(BX20240029);the Beijing Natural Science Foundation(7254462);the Peking University Medicine Sailing Program for Young Scholars’ Scientific & Technological Innovation;the Fundamental Research Funds for the Central Universities(BMU2025YFJHPY044;BMU2025YFJHPY046)
- DOI： 10.1186/s40779-025-00636-w
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- 录用：2025-07-25 ，
- 稿件说明：
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Substantia nigra related gene polymorphisms associated with antipsychotic-induced acute movement disorders: a genome-wide association study and multi-ancestry validation in schizophrenia

Substantia nigra related gene polymorphisms associated with antipsychotic-induced acute movement disorders: a genome-wide association study and multi-ancestry validation in schizophrenia

DOI： 10.1186/s40779-025-00636-w

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