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Decreased IL-33 in the brain following repetitive mild traumatic brain injury contributes to cognitive impairment by inhibiting microglial phagocytosis
RESEARCH | 更新时间:2026-03-26
    • Decreased IL-33 in the brain following repetitive mild traumatic brain injury contributes to cognitive impairment by inhibiting microglial phagocytosis

    • Decreased IL-33 in the brain following repetitive mild traumatic brain injury contributes to cognitive impairment by inhibiting microglial phagocytosis

    • “一项新的研究探讨了IL-33在重复性轻度创伤性脑损伤(rmTBI)中的作用。研究人员使用rmTBI小鼠模型来研究IL-33如何影响认知功能和神经炎症。该研究发现,IL-33可增强小胶质细胞的吞噬作用并减少神经元损伤,这表明它可能是改善rmTBI神经结果的治疗靶点。”
    • Ze-Xi Jia ,Meng-Tian Guo ,Mei-Mei Li ,Pan Liao ,Bo Yan ,Wei Zhang ,Fang-Yuan Cheng ,Ya-Ru Liu ,Zi-Han Zhang ,Cheng Wei ,Jie Zhou ,Fang-Lian Chen ,Ping Lei ,Xin-Tong Ge
    • Military Medical Research 2026年13卷第1期 页码:24-42
    • DOI: 10.1186/s40779-025-00631-1     

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    • 录用:2025-07-16 ,

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相关作者

Xin-Tong Ge
Fang-Lian Chen
Ping Lei
Sahithi Attaluri
Venkata Sai Vashishta Kolla
Leelavathi N. Madhu
Maheedhar Kodali
Charles Huard

相关机构

Institute for Regenerative Medicine, Department of Cell Biology and Genetics, Texas A&M University Health Science Center School of Medicine
Department of Neurology, the Second Xiangya Hospital, Central South University
NHC Key Laboratory of Birth Defect for Research and Prevention, Hunan Provincial Maternal and Child Health Care Hospital
First Clinical Department of Changsha Medical University
National & Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University