Motor protein KIF13B orchestrates hepatic metabolism to prevent metabolic dysfunction-associated fatty liver disease

Guo-Lin Miao; Wen-Xi Zhang; Yi-Tong Xu; Yi-Ran Liu; Ping-Ping Lai; Jia-Bao Guo; Gong-Lie Chen; Jing-Xuan Chen; Zi-Hao Zhou; Yan-Wei Li; Chong Zhang; Yang Ding; Lian-Xin Zhang; Yu-Fei Han; Jin-Xuan Chen; Jing-Dong Wu; Yin-Qi Zhao; Si Mei; Yang Zhao; Yuan-Wu Ma; Ling Zhang; Wei Huang; Dong-Yu Zhao; Er-Dan Dong; Yu-Hui Wang; Xun-De Xian

doi:10.1186/s40779-025-00594-3

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Motor protein KIF13B orchestrates hepatic metabolism to prevent metabolic dysfunction-associated fatty liver disease

RESEARCH | 更新时间：2025-12-13

- Motor protein KIF13B orchestrates hepatic metabolism to prevent metabolic dysfunction-associated fatty liver disease
- Motor protein KIF13B orchestrates hepatic metabolism to prevent metabolic dysfunction-associated fatty liver disease
- “在代谢功能障碍相关脂肪肝（MAFLD）领域，研究人员已经建立了KIF13B缺乏与MAFLD之间的因果关系，为构建治疗MAFLD的潜在治疗靶点奠定了基础。”
- Guo-Lin Miao ，Wen-Xi Zhang ，Yi-Tong Xu ，Yi-Ran Liu ，Ping-Ping Lai ，Jia-Bao Guo ，Gong-Lie Chen ，Jing-Xuan Chen ，Zi-Hao Zhou ，Yan-Wei Li ，Chong Zhang ，Yang Ding ，Lian-Xin Zhang ，Yu-Fei Han ，Jin-Xuan Chen ，Jing-Dong Wu ，Yin-Qi Zhao ，Si Mei ，Yang Zhao ，Yuan-Wu Ma ，Ling Zhang ，Wei Huang ，Dong-Yu Zhao ，Er-Dan Dong ，Yu-Hui Wang ，Xun-De Xian
- Military Medical Research 2025年12卷第9期页码：1329-1349
- 作者机构：
  1.Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing 100191, China
  2.Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing 100191, China
  3.Department of Biomedical Informatics, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing 100191, China
  4.Department of Infectious Diseases, Shengjing Hospital of China Medical University, Shenyang 110134, China
  5.State Key Laboratory of Natural and Biomimetic Drugs, Ministry of Education, Key Laboratory of Cell Proliferation and Differentiation, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Center for Life Sciences, Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing 100871, China
  6.Key Laboratory of Human Disease Comparative Medicine, National Health Commission of China (NHC), Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, Peking Union Medicine College, Beijing 100021, China
  7.Research Center for Cardiopulmonary Rehabilitation, University of Health and Rehabilitation Sciences Qingdao Hospital (Qingdao Municipal Hospital), School of Health and Life Sciences, University of Health and Rehabilitation Sciences, Qingdao 266113, Shandong, China
  8.Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University Third Hospital, Beijing 100191, China
- 作者简介：
  * Dong-Yu Zhao zhaodongyu@bjmu.edu.cn
  Er-Dan Dong donged@bjmu.edu.cn
  Yu-Hui Wang wangyuhui2009@bjmu.edu.cn
  Xun-De Xian xianxunde@bjmu.edu.cn
- 基金信息：
  the National Natural Science Foundation of China(82270479;82070460);the Beijing Natural Science Foundation(7242084);the National Key Research and Development Program of China from the Ministry of Science and Technology(2021YFF0702802)
- DOI： 10.1186/s40779-025-00594-3
  中图分类号：
- 录用：2025-01-16 ，
- 稿件说明：
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Motor protein KIF13B orchestrates hepatic metabolism to prevent metabolic dysfunction-associated fatty liver disease

Motor protein KIF13B orchestrates hepatic metabolism to prevent metabolic dysfunction-associated fatty liver disease

DOI： 10.1186/s40779-025-00594-3

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