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Mechanism of lactic acidemia-promoted pulmonary endothelial cells death in sepsis: role for CIRP-ZBP1-PANoptosis pathway
RESEARCH | 更新时间：2025-12-13
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    • Mechanism of lactic acidemia-promoted pulmonary endothelial cells death in sepsis: role for CIRP-ZBP1-PANoptosis pathway

    • Mechanism of lactic acidemia-promoted pulmonary endothelial cells death in sepsis: role for CIRP-ZBP1-PANoptosis pathway

    • “在脓毒症诱导的急性肺损伤领域，一种新的途径已经被揭示。专家研究表明，脓毒症期间乳酸的积累促进了巨噬细胞来源的细胞外CIRP的释放，这介导了ZBP1依赖性肺血管内皮细胞PANoptosis，加剧了ALI。这一发现为脓毒症相关肺部并发症的分子机制提供了新的见解，并提供了潜在的新治疗策略。”
    • Ting Gong ，Qing-De Wang ，Patricia A. Loughran ，Yue-Hua Li ，Melanie J. Scott ，Timothy R. Billiar ，You-Tan Liu ，Jie Fan
    • MMR 2025年12卷第7期 页码：1023-1045

    • DOI： 10.1186/s40779-024-00574-z     

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相关作者

Wei-Zhen Li
Li-Ting Deng
Huan Yang
Xu-Fei Zhang
Ze-Xing Lin
Ni Kuang
Hai-Yang Jiang
Pei-Zhao Liu

相关机构

Nanjing Medical Key Laboratory of Laryngopharynx-Head and Neck Oncology, the Affiliated BenQ Hospital of Nanjing Medical University
Nanjing Medical University
Department of Emergency Surgery, the Affiliated Hospital of Qingdao University
Department of Infectious Diseases, Chongqing Key Laboratory for Research of Infectious Diseases, Southwest Hospital, Army Medical University
Department of General Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University