PANX1-mediated ATP release confers FAM3A’s suppression effects on hepatic gluconeogenesis and lipogenesis

Cheng-Qing Hu; Tao Hou; Rui Xiang; Xin Li; Jing Li; Tian-Tian Wang; Wen-Jun Liu; Song Hou; Di Wang; Qing-He Zhao; Xiao-Xing Yu; Ming Xu; Xing-Kai Liu; Yu-Jing Chi; Ji-Chun Yang

doi:10.1186/s40779-024-00543-6

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PANX1-mediated ATP release confers FAM3A’s suppression effects on hepatic gluconeogenesis and lipogenesis

RESEARCH | 更新时间：2025-12-13

- PANX1-mediated ATP release confers FAM3A’s suppression effects on hepatic gluconeogenesis and lipogenesis
- PANX1-mediated ATP release confers FAM3A’s suppression effects on hepatic gluconeogenesis and lipogenesis
- “在一项开创性的研究中，研究人员揭示了PANX1介导的ATP释放在维持肝脏糖脂稳态中的关键作用，揭示了FAM3A对肝脏糖异生和脂肪生成的抑制作用。”
- Cheng-Qing Hu ，Tao Hou ，Rui Xiang ，Xin Li ，Jing Li ，Tian-Tian Wang ，Wen-Jun Liu ，Song Hou ，Di Wang ，Qing-He Zhao ，Xiao-Xing Yu ，Ming Xu ，Xing-Kai Liu ，Yu-Jing Chi ，Ji-Chun Yang
- MMR 2025年12卷第5期页码：659-685
- 作者机构：
  1.Department of Physiology and Pathophysiology, School of Basic Medical Sciences/State Key Laboratory of Vascular Homeostasis and Remodeling/Center for Non-Coding RNA Medicine, Peking University Health Science Center, Beijing 100191, China
  2.Department of Obstetrics and Gynecology, Peking University Third Hospital/National Clinical Research Center for Obstetrics and Gynecology, Beijing 100191, China
  3.Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China
  4.Department of Central Laboratory and Institute of Clinical Molecular Biology, Peking University People’s Hospital, Beijing 100044, China
  5.Department of Gastroenterology, Peking University People’s Hospital, Beijing 100044, China
  6.Department of Cardiology, Institute of Vascular Medicine, Peking University Third Hospital/Key Laboratory of Molecular Cardiovascular Science of the Ministry of Education, Beijing 100191, China
  7.Department of Hepatobiliary and Pancreatic Surgery, General Surgery Centre, the First Hospital of Jilin University, Changchun 130061, China
  8.Department of Cardiology, Peking University Third Hospital, Beijing 100191, China
- 作者简介：
  * xingkailiu@foxmail.com
  chiyujing@bjmu.edu.cn
  yangj@bjmu.edu.cn
- 基金信息：
  the National Natural Science Foundation of China(82070844;82230024;82025008);the Natural Science Foundation of Beijing(7212123);the Peking University People’s Hospital Research and Development Funds(RZ2023-01);the Peking University Medicine Seed Fund for Interdisciplinary Research(BMU2023YFJHMX002);the Fundamental Research Funds for the Central Universities
- DOI： 10.1186/s40779-024-00543-6
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PANX1-mediated ATP release confers FAM3A’s suppression effects on hepatic gluconeogenesis and lipogenesis

PANX1-mediated ATP release confers FAM3A’s suppression effects on hepatic gluconeogenesis and lipogenesis

DOI： 10.1186/s40779-024-00543-6

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