Targeting vulnerable microcircuits in the ventral hippocampus of male transgenic mice to rescue Alzheimer-like social memory loss

Hui-Yang Lei; Gui-Lin Pi; Ting He; Rui Xiong; Jing-Ru Lv; Jia-Le Liu; Dong-Qin Wu; Meng-Zhu Li; Kun Shi; Shi-Hong Li; Na-Na Yu; Yang Gao; Hui-Ling Yu; Lin-Yu Wei; Xin Wang; Qiu-Zhi Zhou; Pei-Lin Zou; Jia-Yang Zhou; Ying-Zhou Liu; Nai-Ting Shen; Jie Yang; Dan Ke; Qun Wang; Gong-Ping Liu; Xi-Fei Yang; Jian-Zhi Wang; Ying Yang

doi:10.1186/s40779-024-00512-z

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Targeting vulnerable microcircuits in the ventral hippocampus of male transgenic mice to rescue Alzheimer-like social memory loss

RESEARCH | 更新时间：2025-02-24

- Targeting vulnerable microcircuits in the ventral hippocampus of male transgenic mice to rescue Alzheimer-like social memory loss
- Targeting vulnerable microcircuits in the ventral hippocampus of male transgenic mice to rescue Alzheimer-like social memory loss
- “在阿尔茨海默病研究领域，这项研究阐明了背侧和腹侧海马CA1区之间不同的蛋白质和磷蛋白网络，突出了vCA1微电路对AD样tau积聚的敏感性。值得注意的是，熊果酸在减少tau负荷和靶向vCA1微电路方面的功效可能为未来治疗AD提供了一种有前景的策略。”
- Hui-Yang Lei ，Gui-Lin Pi ，Ting He ，Rui Xiong ，Jing-Ru Lv ，Jia-Le Liu ，Dong-Qin Wu ，Meng-Zhu Li ，Kun Shi ，Shi-Hong Li ，Na-Na Yu ，Yang Gao ，Hui-Ling Yu ，Lin-Yu Wei ，Xin Wang ，Qiu-Zhi Zhou ，Pei-Lin Zou ，Jia-Yang Zhou ，Ying-Zhou Liu ，Nai-Ting Shen ，Jie Yang ，Dan Ke ，Qun Wang ，Gong-Ping Liu ，Xi-Fei Yang ，Jian-Zhi Wang ，Ying Yang
- MMR 2025年12卷第1期页码：48-71
- 作者机构：
  1.Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
  2.Department of Traditional Chinese Medicine, the Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China
  3.Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, Guangdong, China
  4.Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226000, Jiangsu, China
- 作者简介：
  *wangjz@mail.hust.edu.cn;
  yingyang@hust.edu.cn
- 基金信息：
  the National Natural Science Foundation of China(91949205;82071219;82001134;31730035;81721005;82201584);the Special Project of Technological Innovation of Hubei Province(2018ACA142);Guangdong Provincial Key S&T Program(2018B030336001)
- DOI： 10.1186/s40779-024-00512-z
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Targeting vulnerable microcircuits in the ventral hippocampus of male transgenic mice to rescue Alzheimer-like social memory loss

Targeting vulnerable microcircuits in the ventral hippocampus of male transgenic mice to rescue Alzheimer-like social memory loss

DOI： 10.1186/s40779-024-00512-z

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