Targeting the epigenome to reinvigorate T cells for cancer immunotherapy

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Targeting the epigenome to reinvigorate T cells for cancer immunotherapy

REVIEW | 更新时间：2025-12-13

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- Targeting the epigenome to reinvigorate T cells for cancer immunotherapy
- Targeting the epigenome to reinvigorate T cells for cancer immunotherapy
- “在癌症免疫治疗领域，研究人员总结了导致肿瘤微环境中T细胞耗竭的表观遗传学机制，并讨论了靶向表观遗传学调节因子用于免疫治疗的治疗潜力。这为构建涉及免疫刺激剂和表观遗传疗法的治疗范式奠定了基础。”
- Dian Xiong ，Lu Zhang ，Zhi-Jun Sun
- MMR 2024年11卷第6期页码：863-886
- 作者机构：
  1.State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan 430079, China
  2.Department of Oral Maxillofacial-Head Neck Oncology, School and and Hospital of Stomatology, Wuhan University, Wuhan 430079, China
- 作者简介：
  *luzhang2012@whu.edu.cn;
  sunzj@whu.edu.cn
- 基金信息：
  the National Natural Science Foundation of China(82273202;82370948;82072996;82170941);the Fundamental Research Funds for the Central Universities(2042022dx0003);the Hubei Province International Science and Technology Cooperation Project(2021EHB027);the National Key Research and Development Program(2022YFC2504200)
- DOI： 10.1186/s40779-023-00496-2
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