Intracellular accumulation of tau inhibits autophagosome formation by activating TIA1-amino acid-mTORC1 signaling

Meng-Zhu Li; En-Jie Liu; Qiu-Zhi Zhou; Shi-Hong Li; Shi-Jie Liu; Hai-Tao Yu; Qi-Hang Pan; Qi-Hang Pan; Fei Sun; Ting He; Wei-Jin Wang; Dan Ke; Yu-Qi Feng; Jun Li; Jian-Zhi Wang

doi:10.1186/s40779-022-00396-x

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Intracellular accumulation of tau inhibits autophagosome formation by activating TIA1-amino acid-mTORC1 signaling

RESEARCH | 更新时间：2023-05-10

- Intracellular accumulation of tau inhibits autophagosome formation by activating TIA1-amino acid-mTORC1 signaling
- Intracellular accumulation of tau inhibits autophagosome formation by activating TIA1-amino acid-mTORC1 signaling
- Meng-Zhu Li ，En-Jie Liu ，Qiu-Zhi Zhou ，Shi-Hong Li ，Shi-Jie Liu ，Hai-Tao Yu ，Qi-Hang Pan ，Qi-Hang Pan ，Fei Sun ，Ting He ，Wei-Jin Wang ，Dan Ke ，Yu-Qi Feng ，Jun Li ，Jian-Zhi Wang
- Military Medical Research 2023年10卷第2期页码：175-190
- 作者机构：
  1.Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
  2.Department of Neurosurgery, the Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China
  3.Department of Pathology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
  4.Department of Chemistry, Wuhan University, Wuhan 430072, China
  5.Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226000, Jiangsu, China
- 作者简介：
  * lj690222@sina.com;
  wangjz@mail.hust.edu.cn
- 基金信息：
  grants from the Natural Science Foundation of China(91949205;31730035;81721005);the Science and Technology Committee of China(2016YFC1305800);the Special Project of Technological Innovation of Hubei Province(2018ACA142);Guangdong Provincial Key S&T Program(2018B030336001)
- DOI： 10.1186/s40779-022-00396-x
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