Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect

Piao Luo; Qian Zhang; Tian-Yu Zhong; Jia-Yun Chen; Jun-Zhe Zhang; Ya Tian; Liu-Hai Zheng; Fan Yang; Ling-Yun Dai; Chang Zou; Zhi-Jie Li; Jing-Hua Liu; Ji-Gang Wang

doi:10.1186/s40779-022-00381-4

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Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect

RESEARCH | 更新时间：2023-03-23

- Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect
- Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect
- Piao Luo ，Qian Zhang ，Tian-Yu Zhong ，Jia-Yun Chen ，Jun-Zhe Zhang ，Ya Tian ，Liu-Hai Zheng ，Fan Yang ，Ling-Yun Dai ，Chang Zou ，Zhi-Jie Li ，Jing-Hua Liu ，Ji-Gang Wang
- 解放军医学杂志（英文版） 2023年10卷第1期页码：17-31
- 作者机构：
  1.Artemisinin Research Center, and Institute of Chinese Materia Medica, Chinese Academy of Chinese Medical Sciences, Beijing 100700 , China
  2.Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515 , China
  3.Laboratory Medicine, the First Affiliated Hospital of Gannan Medical University, Ganzhou 341000 , Jiangxi, China
  4.Department of Geriatric Medicine, Shenzhen People’s Hospital, the Second Clinical Medical College, Jinan University and the First Affiliated Hospital, Southern University of Science and Technology, Shenzhen 518020 , Guangdong, China
  5.Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515 , China
  6.Center for Reproductive Medicine, Dongguan Maternal and Child Health Care Hospital, Southern Medical University, Dongguan 523125 , Guangdong, China
  7.Central People’s Hospital of Zhanjiang, Zhanjiang 524037 , Guangdong, China
- 作者简介：
  * li.zhijie@szhospital.com;
  liujhua@smu.edu.cn;
  jgwang@icmm.ac.cn
- 基金信息：
  the National Key Research and Development Program of China(2020YFA0908000);the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-C-202002);the National Natural Science Foundation of China(82074098;81841001);the Fundamental Research Funds for the Central Public Welfare Research Institutes(ZXKT18003)
- DOI： 10.1186/s40779-022-00381-4
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