Gadd45a knockout alleviates cisplatin-induced hearing loss by inhibiting CXCL family protein expression

Wei-Long Wang; Sheng-Yu Zou; Dan-Qi Wang; Yue Liu; Jia-Wen Li; Fang-Zi Ke; Si-Hui Wen; Bo-Wen Xu; Kun Lin; Chun-Jiang Wei; Xiao-Long Fu; Qiao-Jun Fang; Xiao-Xiang Xu; Xiong Chen; Zu-Hong He

doi:10.1016/j.mmr.2026.100063

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Gadd45a knockout alleviates cisplatin-induced hearing loss by inhibiting CXCL family protein expression

RESEARCH | 更新时间：2026-09-09

- Gadd45a knockout alleviates cisplatin-induced hearing loss by inhibiting CXCL family protein expression
- Gadd45a knockout alleviates cisplatin-induced hearing loss by inhibiting CXCL family protein expression
- “一个研究小组介绍了其在预防顺铂引起的听力损失方面的进展。研究人员通过CRISPR-Cas9筛选建立了GADD45A-NF-κB1-CXCL信号通路，为解决化疗耳毒性问题提供了解决方案。”
- Wei-Long Wang ，Sheng-Yu Zou ，Dan-Qi Wang ，Yue Liu ，Jia-Wen Li ，Fang-Zi Ke ，Si-Hui Wen ，Bo-Wen Xu ，Kun Lin ，Chun-Jiang Wei ，Xiao-Long Fu ，Qiao-Jun Fang ，Xiao-Xiang Xu ，Xiong Chen ，Zu-Hong He
- 军事医学研究（英文） 2026年
- 作者机构：
  Department of Otorhinolaryngology-Head and Neck Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
  Medical Science and Technology Innovation Center, Institute of Brain Science and Brain-inspired Research, Shandong Provincial Hospital, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, China
  Department of Otolaryngology-Head and Neck Surgery, the Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China
  Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Medicine, Advanced Institute for Life and Health, Southeast University, Nanjing 210096, China
  Department of Otolaryngology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China
- 作者简介：
  *Qiao-Jun Fang, qiaojunfang@ahmu.edu.cn
  Xiao-Xiang Xu, zn003504@whu.edu.cn
  Xiong Chen, zn_chenxiong@whu.edu.cn
  Zu-Hong He, hezuhong@163.com
- 基金信息：
  the National Key Research and Development Program of China(2023YFA1801801;2024YFA1108200);the National Natural Science Foundation of China(82222017;82271183;82571327;82301319;82271181);the Jiangsu Provincial Key Science and Technology Program(BG2024037);the Hubei Provincial Key Health Science and Technology Program(WJ2025Z006)
- DOI： 10.1016/j.mmr.2026.100063
  中图分类号：
- 录用：2026-08-07 ，
- 稿件说明：
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Gadd45a knockout alleviates cisplatin-induced hearing loss by inhibiting CXCL family protein expression

Gadd45a knockout alleviates cisplatin-induced hearing loss by inhibiting CXCL family protein expression

DOI： 10.1016/j.mmr.2026.100063

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