ZBP1 activated by mitochondrial damage binds to STAT3 to suppress Legumain production and exacerbate macrophage inflammation in Klebsiella pneumoniae-induced sepsis

Li-Ting Deng; Huan Yang; Xu-Fei Zhang; Ze-Xing Lin; Ni Kuang; Hai-Yang Jiang; Pei-Zhao Liu; Yang-Guang Li; Xuan-Heng Li; Wei-Zhen Li; Chu-Jun Ni; Ming-Jie Qiu; Yue Chao; Yu-Fei Pan; Yi-Yu Yang; Ye-Ting Zhu; Yun Zhao; Jian-An Ren; Xiu-Wen Wu

doi:10.1016/j.mmr.2026.100059

您当前的位置：

首页 >

文章列表页 >

ZBP1 activated by mitochondrial damage binds to STAT3 to suppress Legumain production and exacerbate macrophage inflammation in Klebsiella pneumoniae-induced sepsis

RESEARCH | 更新时间：2026-08-21

- ZBP1 activated by mitochondrial damage binds to STAT3 to suppress Legumain production and exacerbate macrophage inflammation in Klebsiella pneumoniae-induced sepsis
- ZBP1 activated by mitochondrial damage binds to STAT3 to suppress Legumain production and exacerbate macrophage inflammation in Klebsiella pneumoniae-induced sepsis
- “一个研究小组揭示了ZBP1-STAT3-LGMN信号轴驱动肺炎克雷伯氏菌败血症，确定巨噬细胞ZBP1通过STAT3抑制抗炎LGMN。专家的遗传和髓系特异性敲除模型证实，靶向ZBP1或恢复LGMN活性可以减少细胞因子的产生并提高存活率，这为治疗严重细菌感染提供了解决方案，并为脓毒症免疫疗法的构建奠定了基础。”
- Li-Ting Deng ，Huan Yang ，Xu-Fei Zhang ，Ze-Xing Lin ，Ni Kuang ，Hai-Yang Jiang ，Pei-Zhao Liu ，Yang-Guang Li ，Xuan-Heng Li ，Wei-Zhen Li ，Chu-Jun Ni ，Ming-Jie Qiu ，Yue Chao ，Yu-Fei Pan ，Yi-Yu Yang ，Ye-Ting Zhu ，Yun Zhao ，Jian-An Ren ，Xiu-Wen Wu
- 军事医学研究（英文） 2026年
- 作者机构：
  School of Medicine, Southeast University, Nanjing 210009, China
  Research Institute of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210002, China
  Department of General Surgery, Clinical Translational Research Center for Surgical Infection and Immunity, the Affiliated BenQ Hospital of Nanjing Medical University, Nanjing 210026, China
  Department of General Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China
  Department of Infectious Diseases, Chongqing Key Laboratory for Research of Infectious Diseases, Southwest Hospital, Army Medical University, Chongqing 400038, China
  Department of Emergency Surgery, the Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong, China
  Nanjing Medical University, Nanjing 210000, China
  Nanjing Medical Key Laboratory of Laryngopharynx-Head and Neck Oncology, the Affiliated BenQ Hospital of Nanjing Medical University, Nanjing 210026, China
- 作者简介：
  *Yun Zhao, zhaoyun@njmu.edu.cn;
  Jian-An Ren, jiananr@nju.edu.cn;
  Xiu-Wen Wu, wuxiuwen@nju.edu.cn
- 基金信息：
  the National Natural Science Foundation of China(82272237;82430083);the Jiangsu Provincial Distinguished Young Scholar Program(BK20250108);the Jiangsu Provincial Medical Innovation Center(CXZX202217)
- DOI： 10.1016/j.mmr.2026.100059
  中图分类号：
- 录用：2026-07-24 ，
- 稿件说明：
移动端阅览
DOI：
DOI：

AI导读
HTML全文
图( 9 ) 表( 0 )
参考文献
出版信息
数据统计

38

浏览量

4

下载量

0

CSCD

文章被引用时，请邮件提醒。

提交

工具集

BibTeX下载
Endnote下载
RefMan 下载
NoteExpress下载
NoteFirst下载

关联资源

Endothelial barrier and sepsis: mechanisms and potential therapeutic strategies

A call for further evidence regarding the association between metabolic syndrome, sepsis, and sepsis-related death

The cellular response capacity (CRC) as a novel immunomonitoring approach in sepsis

Sepsis in burns: lessons learned, challenges remain

ZBP1 activated by mitochondrial damage binds to STAT3 to suppress Legumain production and exacerbate macrophage inflammation in Klebsiella pneumoniae-induced sepsis

ZBP1 activated by mitochondrial damage binds to STAT3 to suppress Legumain production and exacerbate macrophage inflammation in Klebsiella pneumoniae-induced sepsis

DOI： 10.1016/j.mmr.2026.100059

AI导读

HTML全文

图( 9 ) 表( 0 )

参考文献

出版信息

数据统计

摘要

Abstract

关键词

Keywords

references