RIMKLA promotes hypertension by activating PKM2 to trigger VSMC phenotype switch

Rui Xiang; Wen-Jun Liu; Xin-Rui Zhang; Han Yan; Xin Li; Song Hou; Cheng-Qing Hu; Yun-Tao Hu; Ru-Feng Ma; Jing Li; Yu-Jing Chi; Qing-Hua Cui; Zhen-Zhen Chen; Bin Geng; Ji-Chun Yang

doi:10.1016/j.mmr.2026.100056

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RIMKLA promotes hypertension by activating PKM2 to trigger VSMC phenotype switch

RESEARCH | 更新时间：2026-08-21

- RIMKLA promotes hypertension by activating PKM2 to trigger VSMC phenotype switch
- RIMKLA promotes hypertension by activating PKM2 to trigger VSMC phenotype switch
- “研究人员将RIMKLA确定为高血压的关键调节因子，确定这种支架蛋白通过葡萄糖代谢重编程招募PTP1B和PKM2来驱动血管平滑肌细胞表型转换，这为靶向抗高血压治疗的发展开辟了新的方向。”
- Rui Xiang ，Wen-Jun Liu ，Xin-Rui Zhang ，Han Yan ，Xin Li ，Song Hou ，Cheng-Qing Hu ，Yun-Tao Hu ，Ru-Feng Ma ，Jing Li ，Yu-Jing Chi ，Qing-Hua Cui ，Zhen-Zhen Chen ，Bin Geng ，Ji-Chun Yang
- 军事医学研究（英文） 2026年
- 作者机构：
  Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Center for Non-coding RNA Medicine, Peking University Health Science Center, Beijing 100191, China
  Department of Pathophysiology, School of Basic Medical Sciences and Public Health, Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, Medical Department, Jiangsu University, Zhenjiang 212013, Jiangsu, China
  Department of Physiology, School of Basic Medical Science, Kunming Medical University, Kunming 650500, China
  Department of Endocrinology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310058, China
  Department of Obstetrics and Gynecology, Peking University Third Hospital/National Clinical Research Center for Obstetrics and Gynecology, State Key Laboratory of Female Fertility Promotion, Beijing 100191, China
  Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China
  Department of Central Laboratory and Institute of Clinical Molecular Biology, Peking University People’s Hospital, Beijing 100044, China
  Department of Biomedical Informatics, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Center for Non-coding RNA Medicine, Peking University Health Science Center, Beijing 100191, China
  Beijing Anzhen Hospital of Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing 100029, China
  State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, CAMS & PUMC, Beijing 102308, China
  Department of Cardiology, Peking University Third Hospital, Beijing 100191, China
- 作者简介：
  *Qing-Hua Cui, cuiqinghua@bjmu.edu.cn;
  Zhen-Zhen Chen, chenzhenzhen@bjmu.edu.cn;
  Bin Geng, bingeng@hsc.pku.edu.cn;
  Ji-Chun Yang, yangj@bjmu.edu.cn
- 基金信息：
  the Noncommunicable Chronic Diseases-National Science and Technology Major Project(2024ZD0523100);the National Natural Science Foundation of China(82300501;82230024;82025008;82370448;82470461;82070844;82300957;82400960);the Peking University Medicine Seed Fund for Interdisciplinary Research(BMU2023YFJHMX002);the Fundamental Research Funds for the Central Universities
- DOI： 10.1016/j.mmr.2026.100056
  中图分类号：
- 录用：2026-07-20 ，
- 稿件说明：
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RIMKLA promotes hypertension by activating PKM2 to trigger VSMC phenotype switch

RIMKLA promotes hypertension by activating PKM2 to trigger VSMC phenotype switch

DOI： 10.1016/j.mmr.2026.100056

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