Downregulation of FTO aggravates osteoarthritis with obesity by erasing m6A methylation of PDP2

Xu-Ying Sun; Jing-Yue Su; Xin Chen; Yi-Xin Yang; Sheng-Wu Yang; Chun-Wu Zhang; Yu-Sheng Li; Jian Xu; Zhen-Han Deng

doi:10.1016/j.mmr.2026.100054

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Downregulation of FTO aggravates osteoarthritis with obesity by erasing m⁶A methylation of PDP2

RESEARCH | 更新时间：2026-08-21

- Downregulation of FTO aggravates osteoarthritis with obesity by erasing m⁶A methylation of PDP2
- Downregulation of FTO aggravates osteoarthritis with obesity by erasing m⁶A methylation of PDP2
- “一项新的研究表明，FTO基因下调通过FTO/YTHDF2/PDP2轴驱动肥胖相关骨关节炎的进展，为这种退行性关节疾病提供了有前景的治疗靶点。”
- Xu-Ying Sun ，Jing-Yue Su ，Xin Chen ，Yi-Xin Yang ，Sheng-Wu Yang ，Chun-Wu Zhang ，Yu-Sheng Li ，Jian Xu ，Zhen-Han Deng
- 军事医学研究（英文） 2026年
- 作者机构：
  Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
  Department of Orthopedics, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China
  Geriatrics Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China
  Department of Epidemiology, University of California, Los Angeles, CA 90095, USA
  Department of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, China
  Department of Orthopedics, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
- 作者简介：
  Jian Xu, 0022029@zju.edu.cn
  *Zhen-Han Deng, dengzhenhan@wmu.edu.cn;
- 基金信息：
  the National Natural Science Foundation of China(82472495;82472559);the Medical and Health Research Project of Zhejiang Province(2024KY1270);the Key Discipline of Traditional Chinese Medicine of Zhejiang Province-Clinical Integration of Chinese and Western Medicine (TCM Orthopedics and Traumatology) of the First Affiliated Hospital of Wenzhou Medical University(2024-XK-50);Zhejiang Clinovation Pride (Fragility Fracture Primary Osteoporosis);the Provincial Advantageous Characteristic Discipline of Wenzhou Medical University (Clinical Medicine)
- DOI： 10.1016/j.mmr.2026.100054
  中图分类号：
- 录用：2026-07-09 ，
- 稿件说明：
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Downregulation of FTO aggravates osteoarthritis with obesity by erasing m⁶A methylation of PDP2

Downregulation of FTO aggravates osteoarthritis with obesity by erasing m⁶A methylation of PDP2

DOI： 10.1016/j.mmr.2026.100054

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