Crosstalk in the brain tumor microenvironment: mechanisms, therapeutic strategies, and clinical advances

Gui-Long Tanzhu; Liu Chen; Jiao-Yang Ning; Gang Xiao; Su Wen; Ce Wang; Hao Wen; Ke-Qin Zhang; Jie Yang; Mu-Yuan Jia; Hai-Bin Deng; Thomas Michael Marti; Paul R Lockman; Rong-Rong Zhou

doi:10.1016/j.mmr.2026.100047

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Crosstalk in the brain tumor microenvironment: mechanisms, therapeutic strategies, and clinical advances

REVIEW | 更新时间：2026-08-21

- Crosstalk in the brain tumor microenvironment: mechanisms, therapeutic strategies, and clinical advances
- Crosstalk in the brain tumor microenvironment: mechanisms, therapeutic strategies, and clinical advances
- “脑瘤对健康构成严重威胁，预后不佳。本文综述了脑肿瘤微环境的研究进展。专家们建立了单细胞和空间转录组学系统，探索了细胞异质性和空间组织，为肿瘤发展和治疗研究开辟了新的方向。”
- Gui-Long Tanzhu ，Liu Chen ，Jiao-Yang Ning ，Gang Xiao ，Su Wen ，Ce Wang ，Hao Wen ，Ke-Qin Zhang ，Jie Yang ，Mu-Yuan Jia ，Hai-Bin Deng ，Thomas Michael Marti ，Paul R Lockman ，Rong-Rong Zhou
- 军事医学研究（英文） 2026年
- 作者机构：
  Department of Oncology, Xiangya Hospital, Central South University, Changsha 410000, China
  Department of Radiation Oncology, Hunan Cancer Hospital/Affiliated Hospital of Xiangya School of Medicine, Central South University, Changsha 410000, China
  Key Laboratory of Translational Radiation Oncology, Department of Radiation Oncology, Hunan Cancer Hospital, Changsha 410000, China
  Department of Radiology, China-Japan Friendship Hospital, Beijing 100029, China
  Department of Nuclear Medicine, the Third Xiangya Hospital, Central South University, Changsha 410000, China
  Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410000, China
  Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410000, China
  National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410000, China
  Department of General Thoracic Surgery, Inselspital, Bern University Hospital, University of Bern, Bern 3008, Switzerland
  Department for BioMedical Research, University of Bern, Bern 3008, Switzerland
  Department of Pharmaceutical Sciences, West Virginia University School of Pharmacy, Morgantown, WV 26505, USA
  Department of Neuroscience, West Virginia University School of Medicine, Rockefeller Neuroscience Institute, Morgantown, WV 26505, USA
  Xiangya Lung Cancer Center, Xiangya Hospital, Central South University, Changsha 410000, China
- 作者简介：
  Hai-Bin Deng, haibin.deng@csu.edu.cn;
  Thomas Michael Marti, thomas. Marti@insel.ch;
  Paul R Lockman, prlockman@hsc.wvu.edu
  *Rong-Rong Zhou, zhourr@csu.edu.cn;
- 基金信息：
  the Advanced Lung Cancer Targeted Therapy Research Foundation of China(CTONG-YC20210303);the Chen Xiao-Ping Foundation for the Development of Science and Technology of Hubei Province(CXPJJH121005-01);the Health Research Project of Hunan Provincial Health Commission(W20242005);the National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University(2022LNJJ10);the Hunan SJA Laboratory Animal Co., Ltd(20241205CY);the National Multidisciplinary Cooperative Diagnosis and Treatment Capacity(z027002)
- DOI： 10.1016/j.mmr.2026.100047
  中图分类号：
- 录用：2026-06-16 ，
- 稿件说明：
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Crosstalk in the brain tumor microenvironment: mechanisms, therapeutic strategies, and clinical advances

Crosstalk in the brain tumor microenvironment: mechanisms, therapeutic strategies, and clinical advances

DOI： 10.1016/j.mmr.2026.100047

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