The role of the tumor microenvironment in mediating radiopharmaceutical therapy: bridging nuclear medicine and cancer immunotherapy

Zhi-Peng Wang; Ai-Qing Li; Dilinaer Wusiman; Rui-Cheng Wu; Ji-Min Zhu; Xin-Rui Li; Yuan-Ning Guo; Premkamon Chaipanichkul; Uzoamaka Adaobi Okoli; Siang Boon Koh; Jie Wang; Deng-Xiong Li; Xiao-Dong Jin; Da-Hong Zhang; Cheema Umber; Qi Zhang; De-Chao Feng

doi:10.1016/j.mmr.2026.100038

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The role of the tumor microenvironment in mediating radiopharmaceutical therapy: bridging nuclear medicine and cancer immunotherapy

REVIEW | 更新时间：2026-06-12

- The role of the tumor microenvironment in mediating radiopharmaceutical therapy: bridging nuclear medicine and cancer immunotherapy
- The role of the tumor microenvironment in mediating radiopharmaceutical therapy: bridging nuclear medicine and cancer immunotherapy
- “放射药物治疗重塑肿瘤微环境以提高癌症免疫力，而缺氧和坚硬的细胞外基质限制了其疗效。研究人员开发了免疫检查点抑制剂和CAR-T细胞的联合策略，推进了癌症的精准治疗。”
- Zhi-Peng Wang ，Ai-Qing Li ，Dilinaer Wusiman ，Rui-Cheng Wu ，Ji-Min Zhu ，Xin-Rui Li ，Yuan-Ning Guo ，Premkamon Chaipanichkul ，Uzoamaka Adaobi Okoli ，Siang Boon Koh ，Jie Wang ，Deng-Xiong Li ，Xiao-Dong Jin ，Da-Hong Zhang ，Cheema Umber ，Qi Zhang ，De-Chao Feng
- 军事医学研究（英文） 2026年
- 作者机构：
  Department of Urology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China
  The Center of Psychosomatic Medicine, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China
  Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN 47907, USA
  Division of Surgery & Interventional Science, University College London, London W1W 7TS, UK
  Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China
  Department of Gastroenterology and Hepatology and Shanghai Institute of Liver Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China
  Department of Rehabilitation, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan, China
  Rappaport Family Institute for Research in the Medical Sciences, Technion-Israel Institute of Technology, Haifa 31096, Israel
  Department of Radiology, Division of Radiation Oncology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
  Basic and Translational Cancer Research Group, Department of Pharmacology and Therapeutics, College of Medicine, University of Nigeria, Enugu 340001, Nigeria
  Faculty of Health and Life Sciences, University of Bristol, Bristol BS8 1TD, UK
  Department of Urology, the First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou 310009, China
  Urology & Nephrology Center, Department of Urology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou 310014, China
- 作者简介：
  Da-Hong Zhang, urology@zju.edu.cn
  Cheema Umber, u.cheema@ucl.ac.uk;
  Qi Zhang, zhangqi1@hmc.edu.cn;
  *De-Chao Feng, dechao.feng@ucl.ac.uk;
- 基金信息：
  the National Health Commission of the People’s Republic of China-Zhejiang Province Jointly Constructed Project, Zhejiang Province Medical and Health Science and Technology Plan(WKJ-ZJ-2517);Clinical-Basic Joint Research Project of Zhejiang Provincial People’s Hospital Affiliated with Hangzhou Medical College(C-2025-YXLH09);This program was supported by the Chinese Scholarship Council(202206240086)
- DOI： 10.1016/j.mmr.2026.100038
  中图分类号：
- 录用：2026-04-26 ，
- 稿件说明：
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The role of the tumor microenvironment in mediating radiopharmaceutical therapy: bridging nuclear medicine and cancer immunotherapy

The role of the tumor microenvironment in mediating radiopharmaceutical therapy: bridging nuclear medicine and cancer immunotherapy

DOI： 10.1016/j.mmr.2026.100038

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