Targeting intratumoral bacteria reverses MHC-I suppression and enhances nano-based chemoimmunotherapy in colorectal cancer

Jing Feng; Yan-Hong Liu; Li-Ming Gong; Wen-Xuan Zhang; Chen-Fei Liu; Cong-Cong Xiao; Li-Qing Chen; Ming-Ji Jin; You-Yan Guan; Zhong-Gao Gao; Wei Huang

doi:10.1016/j.mmr.2026.100036

您当前的位置：

首页 >

文章列表页 >

Targeting intratumoral bacteria reverses MHC-I suppression and enhances nano-based chemoimmunotherapy in colorectal cancer

RESEARCH | 更新时间：2026-06-12

- Targeting intratumoral bacteria reverses MHC-I suppression and enhances nano-based chemoimmunotherapy in colorectal cancer
- Targeting intratumoral bacteria reverses MHC-I suppression and enhances nano-based chemoimmunotherapy in colorectal cancer
- “一个研究小组介绍了其在癌症免疫治疗方面的进展。研究人员建立了一种共负载银纳米粒子和紫杉醇的脂质体纳米系统，该系统提供了消除肿瘤内核梭杆菌同时逆转免疫逃避的解决方案，为将微生物清除与化学免疫疗法相结合奠定了基础。”
- Jing Feng ，Yan-Hong Liu ，Li-Ming Gong ，Wen-Xuan Zhang ，Chen-Fei Liu ，Cong-Cong Xiao ，Li-Qing Chen ，Ming-Ji Jin ，You-Yan Guan ，Zhong-Gao Gao ，Wei Huang
- 军事医学研究（英文） 2026年
- 作者机构：
  State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  Beijing Key Laboratory of Key Technologies for Natural Drug Delivery and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  Department of Pharmacy, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School of Nanjing Medical University, Suzhou 215000, Jiangsu, China
  Department of Urology, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
- 作者简介：
  *Corresponding author: You-Yan Guan, guanyouyan@cicams.ac.cn;
  Zhong-Gao Gao, zggao@imm.ac.cn;
  Wei Huang, huangwei@imm.ac.cn
- 基金信息：
  the Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences (CIFMS)(2021-I2M-1-026)
- DOI： 10.1016/j.mmr.2026.100036
  中图分类号：
- 录用：2026-04-19 ，
- 稿件说明：
移动端阅览
DOI：
DOI：

AI导读
HTML全文
图( 7 ) 表( 0 )
参考文献
出版信息
数据统计

27

浏览量

17

下载量

0

CSCD

文章被引用时，请邮件提醒。

提交

工具集

BibTeX下载
Endnote下载
RefMan 下载
NoteExpress下载
NoteFirst下载

关联资源

Re-expression of DIRAS3 and p53 induces apoptosis and impaired autophagy in head and neck squamous cell carcinoma

Programmed cell death and its role in inflammation

Effectiveness and cost-effectiveness of risk-adapted colorectal cancer screening: a randomized controlled trial and modeling analysis

ALDH2 in autophagy and cell death: molecular mechanisms and implications for diseases

Targeting intratumoral bacteria reverses MHC-I suppression and enhances nano-based chemoimmunotherapy in colorectal cancer

Targeting intratumoral bacteria reverses MHC-I suppression and enhances nano-based chemoimmunotherapy in colorectal cancer

DOI： 10.1016/j.mmr.2026.100036

AI导读

HTML全文

图( 7 ) 表( 0 )

参考文献

出版信息

数据统计

摘要

Abstract

关键词

Keywords

references