Metabolic syndrome and risk of sepsis and sepsis-related mortality: evidence from two large prospective cohort studies

Shao-Yu Liu; Shao-Kang Xu; Jing-Li Gao; Xiao-Ke Kong; Jian Shi; Ya Miao; Yi-Ting Tang; Bin Zhao; Fang Fang; Ai-Tian Wang; Shou-Ling Wu; Jia-Qi Huang; Ben Lu

doi:10.1016/j.mmr.2026.100031

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Metabolic syndrome and risk of sepsis and sepsis-related mortality: evidence from two large prospective cohort studies

RESEARCH | 更新时间：2026-10-12

- Metabolic syndrome and risk of sepsis and sepsis-related mortality: evidence from two large prospective cohort studies
- Metabolic syndrome and risk of sepsis and sepsis-related mortality: evidence from two large prospective cohort studies
- “英国和中国队列的一项大规模研究表明，代谢综合征显著增加了败血症的风险和死亡率，炎症部分介导了这种联系。研究人员证实，改变健康的生活方式可以大大降低这些风险，强调代谢健康维护是减少败血症负担的关键策略。”
- Shao-Yu Liu ，Shao-Kang Xu ，Jing-Li Gao ，Xiao-Ke Kong ，Jian Shi ，Ya Miao ，Yi-Ting Tang ，Bin Zhao ，Fang Fang ，Ai-Tian Wang ，Shou-Ling Wu ，Jia-Qi Huang ，Ben Lu
- 军事医学研究（英文） 2026年13卷第9期页码：1462-1478
- 作者机构：
  Department of Critical Care Medicine and Hematology, the Second Xiangya Hospital, Central South University, Changsha 410011, China
  Department of Critical Care Medicine and Hematology, the Third Xiangya Hospital, Central South University, Changsha 410011, China
  Department of Intensive Medicine, Kailuan General Hospital, Tangshan 063000, Hebei, China
  National Clinical Research Center for Endocrine and Metabolic Diseases, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology, Ministry of Education, and Department of Metabolism and Endocrinology, the Second Xiangya Hospital of Central South University, Changsha 410011, China
  CSU-Sinocare Research Center for Nutrition and Metabolic Health, Xiangya School of Public Health, Central South University; Furong Laboratory, Changsha 410011, China
  Hunan Provincial Clinical Research Center for Sepsis, the Third Xiangya Hospital, Central South University, Changsha 410011, China
  Department of Physiology, Xiangya School of Basic Medical Science, Central South University, Changsha 410011, China
  Key Laboratory of Sepsis Translational Medicine of Hunan, Central South University, Changsha 410011, China
  Institute of Environmental Medicine, Karolinska Institutet, Stockholm 171 77, Sweden
  Department of Cardiology, Kailuan General Hospital, Tangshan 063000, Hebei, China
- 作者简介：
  Jia-Qi Huang, JIAQI.HUANG@CSU.EDU.CN
  *Ben Lu, XYBENLU@CSU.EDU.CN;
- 基金信息：
  the National Key R&D Program of China(2024YFF1207100);the Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China(JYB2025XDXM506);the Major Program for Fundamental Research of Hunan Provincial(2025JC0002);the National Outstanding Youth Science Fund Project of the National Natural Science Foundation of China(82025021);the Scientific Research Program of FuRong Laboratory(2024PT5103;2024PT5105);the National Natural Science Foundation of China(82470931);the Hunan Provincial Excellent Youth Science Fund Project(2024JJ4086);the Central South University Research Programme of Advanced Interdisciplinary Studies(2023QYJC008)
- DOI： 10.1016/j.mmr.2026.100031
  中图分类号：
- 录用：2026-04-03 ，
- 稿件说明：
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Metabolic syndrome and risk of sepsis and sepsis-related mortality: evidence from two large prospective cohort studies

Metabolic syndrome and risk of sepsis and sepsis-related mortality: evidence from two large prospective cohort studies

DOI： 10.1016/j.mmr.2026.100031

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