Octopus-inspired engineered bacteria with a plug-and-play surface display system achieves enhanced tumor-specific colonization and antitumor immunity

Le-Yang Wu; Jia-Hui Qiu; Xin-Yue Qiao; Lin Li; Li-Yuan Qiao; Chen-Yang Li; Ying Sun; Shu-Hui Zhang; Zeng-Zheng Du; Xiao-Yao Chang; Cheng Cheng; Bo-Hao Wang; Yi-Han Xiao; Lin Lin; Zi-Chun Hua

doi:10.1016/j.mmr.2026.100030

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Octopus-inspired engineered bacteria with a plug-and-play surface display system achieves enhanced tumor-specific colonization and antitumor immunity

RESEARCH | 更新时间：2026-10-12

- Octopus-inspired engineered bacteria with a plug-and-play surface display system achieves enhanced tumor-specific colonization and antitumor immunity
- Octopus-inspired engineered bacteria with a plug-and-play surface display system achieves enhanced tumor-specific colonization and antitumor immunity
- “研究人员开发了一种受章鱼启发的工程细菌，该细菌具有用于肿瘤特异性药物输送的“即插即用”系统。该团队建立了AISI-ST/SC-RGD×4细菌界面系统，为解决细菌介导的癌症治疗中的毒性和脱靶效应提供了解决方案，为构建精准的临床免疫治疗平台奠定了基础。”
- Le-Yang Wu ，Jia-Hui Qiu ，Xin-Yue Qiao ，Lin Li ，Li-Yuan Qiao ，Chen-Yang Li ，Ying Sun ，Shu-Hui Zhang ，Zeng-Zheng Du ，Xiao-Yao Chang ，Cheng Cheng ，Bo-Hao Wang ，Yi-Han Xiao ，Lin Lin ，Zi-Chun Hua
- 军事医学研究（英文） 2026年13卷第9期页码：1441-1461
- 作者机构：
  State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China
  Changzhou High-Tech Research Institute of Nanjing University and Jiangsu TargetPharma Laboratories, Inc., Changzhou 213164, Jiangsu, China
  School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China
  School of Food and Biological Engineering, Jiangsu University, Nanjing 212013, China
  Faculty of Pharmaceutical Sciences, Xinxiang Medical University, Xinxiang 453002, Henan, China
- 作者简介：
  *Le-Yang Wu, lywu@nju.edu.cn;
  Lin Lin, linl@ujs.edu.cn;
  Zi-Chun Hua, zchua@nju.edu.cn
- 基金信息：
  the National Natural Science Foundation of China(82303774;82130106);the Natural Science Foundation of Jiangsu Province(BK20243001;BG2024026;BK20230165;BE2023695;BY20241051);the Changzhou Municipal Department of Science and Technology(CE20246001;CJ20250023)
- DOI： 10.1016/j.mmr.2026.100030
  中图分类号：
- 录用：2026-04-03 ，
- 稿件说明：
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Octopus-inspired engineered bacteria with a plug-and-play surface display system achieves enhanced tumor-specific colonization and antitumor immunity

Octopus-inspired engineered bacteria with a plug-and-play surface display system achieves enhanced tumor-specific colonization and antitumor immunity

DOI： 10.1016/j.mmr.2026.100030

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