From RCT to mechanistic study: ATRA reverses myofibroblast activation by reprogramming glucose metabolism via HIC1 and PCK1/2 to attenuate hypertrophic scar formation

Zi-Chao Li; Yi-Fu Zhu; Ya-Juan Song; Zhi-Jun Tan; Bin Liu; Yan Jiang; Hou-An Xiao; Dong-Mei Zu; Tong Wang; Yi Shi; Yan Jiao; Xue-Yong Li; Xing-Bo Xu; Lei Shang; Zhou Yu; Bao-Qiang Song

doi:10.1016/j.mmr.2026.100021

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From RCT to mechanistic study: ATRA reverses myofibroblast activation by reprogramming glucose metabolism via HIC1 and PCK1/2 to attenuate hypertrophic scar formation

RESEARCH | 更新时间：2026-10-12

- From RCT to mechanistic study: ATRA reverses myofibroblast activation by reprogramming glucose metabolism via HIC1 and PCK1/2 to attenuate hypertrophic scar formation
- From RCT to mechanistic study: ATRA reverses myofibroblast activation by reprogramming glucose metabolism via HIC1 and PCK1/2 to attenuate hypertrophic scar formation
- “一项多中心随机对照试验显示，维甲酸乳膏在预防增生性瘢痕方面不亚于硅胶。研究人员建立了ATRA/RARα介导的葡萄糖重编程系统，该系统为解决纤维化疾病问题提供了解决方案，并为构建代谢治疗靶点奠定了基础。”
- Zi-Chao Li ，Yi-Fu Zhu ，Ya-Juan Song ，Zhi-Jun Tan ，Bin Liu ，Yan Jiang ，Hou-An Xiao ，Dong-Mei Zu ，Tong Wang ，Yi Shi ，Yan Jiao ，Xue-Yong Li ，Xing-Bo Xu ，Lei Shang ，Zhou Yu ，Bao-Qiang Song
- 军事医学研究（英文） 2026年13卷第9期页码：1417-1440
- 作者机构：
  Department of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
  Department of Plastic and Aesthetic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
  Department of Health Statistics, Ministry of Education Key Laboratory of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, Xi’an 710032, China
  Department of Burn, Plastic and Cosmetic Surgery, Xi’an Central Hospital, Xi’an Jiaotong University, Xi’an 710003, China
  Department of Cosmetology, the Second People’s Hospital of Jiangyou City, Jiangyou 621702, Sichuan, China
  Department of Burns, Plastic and Cosmetic Surgery, Xian Ninth Hospital, Xi’an 710054, China
  Department of Plastic Surgery, People’s Hospital of Ankang City, Ankang 725000, Shaanxi, China
  Department of Burn and Plastic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China
  Department of Burn and Plastic Surgery, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, China
  Clinic for Cardiology and Pulmonology, University Medical Center Göttingen, Göttingen 37075, Germany
- 作者简介：
  Xing-Bo Xu, xingbo.xu@med.uni-goettingen.de;
  *Lei Shang, Shanglei@fmmu.edu.cn;
  Zhou Yu, yz20080512@163.com;
  Bao-Qiang Song, songbq2012@163.com
- 基金信息：
  the National Natural Science Foundation of China(82372530;82072182);the Special Project of Xijing Hospital Clinical Research(XJZT24LZ14);the Intramural Research Program Project founded by Fourth Military Medical University(2024QMJJ014)
- DOI： 10.1016/j.mmr.2026.100021
  中图分类号：
- 录用：2026-03-16 ，
- 稿件说明：
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From RCT to mechanistic study: ATRA reverses myofibroblast activation by reprogramming glucose metabolism via HIC1 and PCK1/2 to attenuate hypertrophic scar formation

From RCT to mechanistic study: ATRA reverses myofibroblast activation by reprogramming glucose metabolism via HIC1 and PCK1/2 to attenuate hypertrophic scar formation

DOI： 10.1016/j.mmr.2026.100021

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