Immune microenvironment dynamics in pregnant patients with concomitant autoimmune diseases: mechanisms, challenges, and clinical significance

Zi-Jun Ma; Jun Chen; Chen-Xi Yang; Shun-Ping Lin; Quan Gong; Zachary Braunstein; Ying-Ying Wei; Xiao-Quan Rao; Ji-Xin Zhong

doi:10.1016/j.mmr.2026.100015

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Immune microenvironment dynamics in pregnant patients with concomitant autoimmune diseases: mechanisms, challenges, and clinical significance

REVIEW | 更新时间：2026-10-12

- Immune microenvironment dynamics in pregnant patients with concomitant autoimmune diseases: mechanisms, challenges, and clinical significance
- Immune microenvironment dynamics in pregnant patients with concomitant autoimmune diseases: mechanisms, challenges, and clinical significance
- “本文综述了自身免疫性疾病妊娠期动态免疫微环境变化的研究进展。最近的多学科研究发现，艾滋病患者的免疫反应存在显著差异，为优化管理策略提供了解决方案，并为个性化治疗方法奠定了基础。”
- Zi-Jun Ma ，Jun Chen ，Chen-Xi Yang ，Shun-Ping Lin ，Quan Gong ，Zachary Braunstein ，Ying-Ying Wei ，Xiao-Quan Rao ，Ji-Xin Zhong
- 军事医学研究（英文） 2026年13卷第9期页码：1515-1542
- 作者机构：
  Department of Rheumatology, Fujian Medical University Union Hospital, Fuzhou 350001, China
  Division of Rheumatology and Immunology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
  Sinopharm Dongfeng General Hospital (Hubei Clinical Research Center of Hypertension), Hubei Key Laboratory of Wudang Local Chinese Medicine Research, Hubei University of Medicine, Shiyan 442000, Hubei, China
  Fujian Institute of Clinical Immunology, Fuzhou 350001, China
  Department of Immunology, School of Medicine, Yangtze University, Jingzhou 434023, Hubei, China
  Division of Hematology, Department of Internal Medicine, James Comprehensive Cancer Center, the Ohio State University Wexner Medical Center, Columbus, OH 43210, USA
  Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
  Key Laboratory of Vascular Aging (HUST), Ministry of Education, Wuhan 430030, China
- 作者简介：
  *Ying-Ying Wei, yying_wei@126.com;
  Xiao-Quan Rao, xqrao@tjh.tjmu.edu.cn;
  Ji-Xin Zhong, zhongjixin620@163.com
- 基金信息：
  the National Natural Science Foundation of China(82572075;82270903;82370465;82401588);the Hubei Key Research and Development Project(2023BCB013);the China Postdoctoral Science Foundation(2024M751019);the Hubei Provincial Hypertension Clinical Medicine Research Center Open Project(HBCH2024002)
- DOI： 10.1016/j.mmr.2026.100015
  中图分类号：
- 录用：2026-03-06 ，
- 稿件说明：
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Immune microenvironment dynamics in pregnant patients with concomitant autoimmune diseases: mechanisms, challenges, and clinical significance

Immune microenvironment dynamics in pregnant patients with concomitant autoimmune diseases: mechanisms, challenges, and clinical significance

DOI： 10.1016/j.mmr.2026.100015

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