RNA as a genome architect: G-loops in G-quadruplex regulation

Jie Wang; Zhao-Jie Lyu; Qi Zhang; William C. Cho; De-Chao Feng

doi:10.1186/s40779-025-00683-3

Your Location：

Home >

Browse articles >

RNA as a genome architect: G-loops in G-quadruplex regulation

COMMENTARY | Updated：2026-08-20

- RNA as a genome architect: G-loops in G-quadruplex regulation
- RNA as a genome architect: G-loops in G-quadruplex regulation
- Military Medical Research 2026年13卷第6期页码：1030-1032
- Affiliations：
  
  Urology & Nephrology Center, Department of Urology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou 310014, China
  Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China
  Department of Urology, Institute of Precision Medicine, Peking University Shenzhen Hospital, Shenzhen, Guangzhou 518036, China
  Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong SAR, China
  Division of Surgery & Interventional Science, University College London, London W1W 7TS, UK
- Author bio：
  
  * William C. Cho chocs@ha.org.hk
  De-Chao Feng dechao.feng@ucl.ac.uk
- Funds：
  
  the National Health Commission of the People’s Republic of China-Zhejiang Province Jointly Constructed Project, Zhejiang Province Medical and Health Science and Technology Plan(WKJ-ZJ-2517);Clinical-Basic Joint Research Project of Zhejiang Provincial People’s Hospital Affiliated with Hangzhou Medical College(C-2025-YXLH09)
- DOI：10.1186/s40779-025-00683-3
  中图分类号：
- 收稿：2025-10-26，
  
  录用：2025-12-10，
  
  网络首发：2026-01-14，
  
  纸质出版：2026-06
- Accepted：
Scan QR Code
Jie Wang, Zhao-Jie Lyu, Qi Zhang, 等. RNA as a genome architect: G-loops in G-quadruplex regulation[J]. Military Medical Research, 2026,13(6):1030-1032.

Jie Wang, Zhao-Jie Lyu, Qi Zhang, et al. RNA as a genome architect: G-loops in G-quadruplex regulation[J]. Military Medical Research, 2026, 13(6): 1030-1032.
Jie Wang, Zhao-Jie Lyu, Qi Zhang, 等. RNA as a genome architect: G-loops in G-quadruplex regulation[J]. Military Medical Research, 2026,13(6):1030-1032. DOI： 10.1186/s40779-025-00683-3.

Jie Wang, Zhao-Jie Lyu, Qi Zhang, et al. RNA as a genome architect: G-loops in G-quadruplex regulation[J]. Military Medical Research, 2026, 13(6): 1030-1032. DOI： 10.1186/s40779-025-00683-3.

摘要

Abstract

关键词

Keywords

references

Varshney D , Spiegel J , Zyner K , Tannahill D , Balasubramanian S . The regulation and functions of DNA and RNA G-quadruplexes . Nat Rev Mol Cell Biol . 2020 ; 21 ( 8 ): 459 - 74 .

Hänsel-Hertsch R , Beraldi D , Lensing SV , Marsico G , Zyner K , Parry A , et al . G-quadruplex structures mark human regulatory chromatin . Nat Genet . 2016 ; 48 ( 10 ): 1267 - 72 .

Sato K , Lyu J , van den Berg J , Braat D , Cruz VM , Navarro Luzón C , et al . RNA transcripts regulate G-quadruplex landscapes through G-loop formation . Science . 2025 ; 388 ( 6752 ): 1225 - 31 .

Jimenez-Sainz J , Mathew J , Moore G , Lahiri S , Garbarino J , Eder JP , et al . BRCA2 BRC missense variants disrupt RAD51-dependent DNA repair . Elife . 2022 ; 11 : e79183 .

Greenhough LA , Liang CC , Belan O , Kunzelmann S , Maslen S , Rodrigo-Brenni MC , et al . Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 tumour suppressor . Nature . 2023 ; 619 ( 7970 ): 650 - 7 .

Gregg SQ , Robinson AR , Niedernhofer LJ . Physiological consequences of defects in ERCC1-XPF DNA repair endonuclease . DNA Repair (Amst) . 2011 ; 10 ( 7 ): 781 - 91 .

Xu H , Hurley LH . A first-in-class clinical G-quadruplex-targeting drug. The bench-to-bedside translation of the fluoroquinolone QQ58 to CX-5461(Pidnarulex) . Bioorg Med Chem Lett . 2022 ; 77 : 129016 .

Wang E , Thombre R , Shah Y , Latanich R , Wang J . G-quadruplexes as pathogenic drivers in neurodegenerative disorders . Nucleic Acids Res . 2021 ; 49 ( 9 ): 4816 - 30 .

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

National and subnational burden and causes of anemia in China from 1990 to 2023: findings from the Global Burden of Disease Study 2023

Burden of antimicrobial resistance in the WHO Southeast Asia and Western Pacific Regions, 1990–2021: a cross-country systematic analysis with forecasts to 2050

Antibacterial efficacy of a chitosan-based hydrogel loaded with epsilon poly-L-lysine and poly(I:C) extracellular vesicles for the control of polymicrobial extremity wound infections in a porcine polytrauma model

Target trial emulation in oncology: current use and future directions

Advanced multifunctional nano-delivery platform focusing on treating diseases related to lipid metabolism via targeted intervention in various lipid metabolic processes