Artificial intelligence in digital pathology diagnosis and analysis: technologies,challenges, and future prospects

Xiu-Ming Zhang; Tian-Hong Gao; Qiu-Yu Cai; Jia-Bin Xia; Yu-Ning Sun; Jian Yang; Wei-Han Li; Sheng-Xu-Ming Zhang; Heng-Rui Lou; Xiao-Tian Yu; Kai-Wen Hu; Jing-Wen Ye; Jin-Xing Zhang; Jie Lei; Le-Chao Cheng; Lin-Jie Xu; Qing Chen; He-Xiang Wang; Mei-Fu Gan; Cheng Lu; Nan Pu; Ming-Li Song; Xin Chen; Wen-Jie Liang; Han Lv; Chao-Qing Xu; Zai-Yi Liu; Jing Zhang; Kai Yan; Zun-Lei Feng

doi:10.1186/s40779-025-00680-6

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Artificial intelligence in digital pathology diagnosis and analysis: technologies,challenges, and future prospects

REVIEW | Updated：2026-01-29

- Artificial intelligence in digital pathology diagnosis and analysis: technologies,challenges, and future prospects
- Artificial intelligence in digital pathology diagnosis and analysis: technologies,challenges, and future prospects
- “人工智能（AI）正在彻底改变病理诊断，但其应用尚未得到系统评估。本综述介绍了人工智能算法和基础模型的技术分类，对它们在诊断任务中的性能进行了基准测试，并确定了临床翻译中的挑战。它提出了一个在精确肿瘤学和病理学研究中推进人工智能应用的路线图，旨在将强大、统一、可扩展的人工智能解决方案集成到诊断工作流程中。”
- Military Medical Research 2025年12卷
- Affiliations：
  
  1.Department of Pathology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China
  2.School of Software Technology, Zhejiang University, Hangzhou 310000, China
  3.State Key Laboratory of Blockchain and Data Security, Zhejiang University, Hangzhou 310000, China
  4.Department of Electrical and Computer Engineering, National University of Singapore, Singapore 119077, Singapore
  5.Department of Interventional Radiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210000, China
  6.College of Computer Science, Zhejiang University of Technology, Hangzhou 310000, China
  7.School of Computer and Information, Hefei University of Technology, Hefei 230000, China
  8.Department of Radiology,the Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong, China
  9.Department of Pathology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou 318000, Zhejiang, China
  10.Department of Radiology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510000, China
  11.The Department of Information Engineering and Computer Science, University of Trento, 38123 Trento, Italy
  12.School of Computer and Computing Science, Hangzhou City University, Hangzhou 310000, China
  13.Department of Radiology, School of Medicine, Guangzhou First People’s Hospital, South China University of Technology, Guangzhou 510000, China
  14.Department of Radiology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310000, China
  15.Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100000, China
  16.Department of Neonatology, Children Hospital of Fudan University, Shanghai 201102, China
- Author bio：
  
  * Chao-Qing Xu xucq@hzcu.edu.cn
  Zai-Yi Liu liuzaiyi@gdph.org.cn
  Jing Zhang jzhang1989@zju.edu.cn
  Kai Yan fhyankai@gmail.com
  Zun-Lei Feng zunleifeng@zju.edu.cn
- Funds：
  
  the National Natural Science Foundation of China(62376248);the Huadong Medicine Joint Fund of the Zhejiang Provincial Natural Science Foundation of China(LHDMZ25H160002);the Zhejiang Province Health Major Science and Technology Program of National Health Commission Scientific Research Fund(WKJ-ZJ-2426);the Fundamental Research Funds for the Central Universities(226–2025-00240);the Information Technology Center, Zhejiang University
- DOI：10.1186/s40779-025-00680-6
  中图分类号：
- 收稿：2025-05-11，
  
  录用：2025-11-26，
  
  网络首发：2026-01-04，
  
  纸质出版：2025
- Accepted：
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Xiu-Ming Zhang, Tian-Hong Gao, Qiu-Yu Cai, 等. Artificial intelligence in digital pathology diagnosis and analysis: technologies,challenges, and future prospects[J/OL]. Military Medical Research, 2025,12.

Xiu-Ming Zhang, Tian-Hong Gao, Qiu-Yu Cai, et al. Artificial intelligence in digital pathology diagnosis and analysis: technologies,challenges, and future prospects[J/OL]. Military Medical Research, 2025, 12.
Xiu-Ming Zhang, Tian-Hong Gao, Qiu-Yu Cai, 等. Artificial intelligence in digital pathology diagnosis and analysis: technologies,challenges, and future prospects[J/OL]. Military Medical Research, 2025,12. DOI： 10.1186/s40779-025-00680-6.

Xiu-Ming Zhang, Tian-Hong Gao, Qiu-Yu Cai, et al. Artificial intelligence in digital pathology diagnosis and analysis: technologies,challenges, and future prospects[J/OL]. Military Medical Research, 2025, 12. DOI： 10.1186/s40779-025-00680-6.

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Artificial intelligence in digital pathology diagnosis and analysis: technologies,challenges, and future prospects

Artificial intelligence in digital pathology diagnosis and analysis: technologies,challenges, and future prospects

DOI：10.1186/s40779-025-00680-6