Dual-locked targeted alpha-emitter enhanced tumor immunotherapy via Diels–Alder reaction-based self-immolative molecular cage strategy

Meng-Die Yang; Kang Fang; Xiao-Yi Zhang; Gang Yang; He-Qing Yi; Le Cai; Shan-Shan Qin; Xin-Da Yang; Rong Rong; Shuo Shi; Fei Yu

doi:10.1186/s40779-025-00673-5

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Dual-locked targeted alpha-emitter enhanced tumor immunotherapy via Diels–Alder reaction-based self-immolative molecular cage strategy

RESEARCH | Updated：2026-06-10

- Dual-locked targeted alpha-emitter enhanced tumor immunotherapy via Diels–Alder reaction-based self-immolative molecular cage strategy
- Dual-locked targeted alpha-emitter enhanced tumor immunotherapy via Diels–Alder reaction-based self-immolative molecular cage strategy
- Military Medical Research 2026年13卷第5期页码：728-746
- Affiliations：
  
  1.Department of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, School of Chemical Science and Engineering, Shanghai 200072, China
  2.Institute of Nuclear Medicine, Tongji University School of Medicine, Shanghai 200072, China
  3.College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
  4.Department of Nuclear Medicine, Zhejiang Cancer Hospital, Hangzhou 310022, China
- Author bio：
  
  * Shuo Shi shishuo@tongji.edu.cn
  Fei Yu 0910110013yufei@tongji.edu.cn; yufei_021@163.com
- Funds：
  
  the National Natural Science Foundation of China(82272030;82472028;22277090);the Construction Project of Shanghai Key Laboratory of Molecular Imaging(18DZ2260400);the Natural Science Foundation of Shanghai(23ZR1466700);the Natural Science Foundation of Shandong Province(ZR2025QC1386)
- DOI：10.1186/s40779-025-00673-5
  中图分类号：
- 收稿：2025-05-14，
  
  录用：2025-11-13，
  
  网络首发：2025-12-01，
  
  纸质出版：2026-05
- Accepted：
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Meng-Die Yang, Kang Fang, Xiao-Yi Zhang, 等. Dual-locked targeted alpha-emitter enhanced tumor immunotherapy via Diels–Alder reaction-based self-immolative molecular cage strategy[J]. Military Medical Research, 2026,13(5):728-746.

Meng-Die Yang, Kang Fang, Xiao-Yi Zhang, et al. Dual-locked targeted alpha-emitter enhanced tumor immunotherapy via Diels–Alder reaction-based self-immolative molecular cage strategy[J]. Military Medical Research, 2026, 13(5): 728-746.
Meng-Die Yang, Kang Fang, Xiao-Yi Zhang, 等. Dual-locked targeted alpha-emitter enhanced tumor immunotherapy via Diels–Alder reaction-based self-immolative molecular cage strategy[J]. Military Medical Research, 2026,13(5):728-746. DOI： 10.1186/s40779-025-00673-5.

Meng-Die Yang, Kang Fang, Xiao-Yi Zhang, et al. Dual-locked targeted alpha-emitter enhanced tumor immunotherapy via Diels–Alder reaction-based self-immolative molecular cage strategy[J]. Military Medical Research, 2026, 13(5): 728-746. DOI： 10.1186/s40779-025-00673-5.

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Dual-locked targeted alpha-emitter enhanced tumor immunotherapy via Diels–Alder reaction-based self-immolative molecular cage strategy

Dual-locked targeted alpha-emitter enhanced tumor immunotherapy via Diels–Alder reaction-based self-immolative molecular cage strategy

DOI：10.1186/s40779-025-00673-5