State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing 100050, China
Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China
Children Hospital of Fudan University, Shanghai 201102, China
Translational Medicine Center, Beijing Chest Hospital, Capital Medical University, Beijing 101149, China
* Hong-Qian Chu chuhongqian@bjxkyy.cn
Jun Ye yelinghao@imm.ac.cn
Yu-Ling Liu ylliu@imm.ac.cn
Yan-Fang Yang yangyf@imm.ac.cn
收稿:2025-04-21,
录用:2025-11-12,
网络首发:2025-12-04,
纸质出版:2026-07
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Ying Sun, Kai Yan, Yi Zhang, 等. Advanced multifunctional nano-delivery platform focusing on treating diseases related to lipid metabolism via targeted intervention in various lipid metabolic processes[J]. Military Medical Research, 2026,13(7):1123-1170.
Ying Sun, Kai Yan, Yi Zhang, et al. Advanced multifunctional nano-delivery platform focusing on treating diseases related to lipid metabolism via targeted intervention in various lipid metabolic processes[J]. Military Medical Research, 2026, 13(7): 1123-1170.
Ying Sun, Kai Yan, Yi Zhang, 等. Advanced multifunctional nano-delivery platform focusing on treating diseases related to lipid metabolism via targeted intervention in various lipid metabolic processes[J]. Military Medical Research, 2026,13(7):1123-1170. DOI: 10.1186/s40779-025-00672-6.
Ying Sun, Kai Yan, Yi Zhang, et al. Advanced multifunctional nano-delivery platform focusing on treating diseases related to lipid metabolism via targeted intervention in various lipid metabolic processes[J]. Military Medical Research, 2026, 13(7): 1123-1170. DOI: 10.1186/s40779-025-00672-6.
Disruptions in lipid metabolism cause numerous metabolic diseases
including obesity
diabetes
cardiovascular diseases
and liver disorders. Consequently
lipid metabolism serves as a potential therapeutic target
influencing the progression of various non-metabolic diseases such as kidney diseases
cancer
neurodegenerative disorders
aging
and bone-related diseases. The metabolic pathways involved in lipid metabolism are complex and highly interconnected. Although the abundance of metabolic targets presents opportunities for lipid metabolism regulation
the limited precision and safety of traditional therapeutic approaches remain significant challenges. These limitations have catalyzed the development of multifunctional nano-delivery platforms aimed at targeted intervention in lipid metabolic processes
further enhancing the flexibility of lipid metabolism regulation. This review outlines the latest advancements and representative applications of these multifunctional nano-delivery platforms. Notably
extensive research has been conducted on nanoparticles and liposomes
with these technologies being relatively mature. Furthermore
numerous novel biomaterials
including engineered adipocytes
exosome vesicles secreted by natural cells
smart-responsive nanomicelles
composite hydrogels
and engineered lipid droplets
are being increasingly explored. Finally
the review discusses the advantages of drug delivery strategies based on the targeted intervention of lipid metabolic processes
the limitations of current technologies
promising future research directions
and treatment challenges.
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