β-catenin initiates peritoneal fibrosis by triggering mitochondrial fission-mediated mesothelial cell senescence fate transition

Xiao-Xu Wang; Wei-Jie Zhong; Jie-Mei Li; Di Wang; Shuang-Qin Chen; Jin-Hua Miao; Wei-Wei Shen; Xiao-Long Li; Jie-Wu Huang; Shan Zhou; Cheng Wang; Jun Ai; Li-Li Zhou

doi:10.1186/s40779-025-00669-1

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β-catenin initiates peritoneal fibrosis by triggering mitochondrial fission-mediated mesothelial cell senescence fate transition

RESEARCH | Updated：2026-01-29

- β-catenin initiates peritoneal fibrosis by triggering mitochondrial fission-mediated mesothelial cell senescence fate transition
- β-catenin initiates peritoneal fibrosis by triggering mitochondrial fission-mediated mesothelial cell senescence fate transition
- “在终末期肾病患者腹膜纤维化治疗领域，一个研究小组取得了重大进展。他们验证了β-catenin信号传导和间皮细胞衰老在腹膜纤维化中的作用，为构建新的治疗干预系统奠定了基础。”
- Military Medical Research 2025年12卷
- Affiliations：
  
  1.Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
  2.State Key Laboratory of Multi-Organ Injury Prevention and Treatment, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
  3.National Clinical Research Center for Kidney Disease, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
  4.Guangdong Provincial Institute of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
  5.Guangdong Provincial Key Laboratory of Renal Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
  6.Division of Nephrology, Department of Medicine, the Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai 519000, Guangdong, China
- Author bio：
  
  * Cheng Wang wangch2@mail.sysu.edu.cn
  Jun Ai aij1980@smu.edu.cn
  Li-Li Zhou jinli730@smu.edu.cn
- Funds：
  
  the National Natural Science Foundation of China(82225010;82370744;82400881);the Guangdong Basic and Applied Basic Research Foundation(2023A1515110906);the Postdoctoral Science Foundation of China(2023M731558);the Postdoctoral Fellowship Program of China Postdoctoral Science Foundation(GZC20231060)
- DOI：10.1186/s40779-025-00669-1
  中图分类号：
- 收稿：2025-02-19，
  
  录用：2025-11-03，
  
  网络首发：2025-12-01，
  
  纸质出版：2025
- Accepted：
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Xiao-Xu Wang, Wei-Jie Zhong, Jie-Mei Li, 等. β-catenin initiates peritoneal fibrosis by triggering mitochondrial fission-mediated mesothelial cell senescence fate transition[J/OL]. Military Medical Research, 2025,12.

Xiao-Xu Wang, Wei-Jie Zhong, Jie-Mei Li, et al. β-catenin initiates peritoneal fibrosis by triggering mitochondrial fission-mediated mesothelial cell senescence fate transition[J/OL]. Military Medical Research, 2025, 12.
Xiao-Xu Wang, Wei-Jie Zhong, Jie-Mei Li, 等. β-catenin initiates peritoneal fibrosis by triggering mitochondrial fission-mediated mesothelial cell senescence fate transition[J/OL]. Military Medical Research, 2025,12. DOI： 10.1186/s40779-025-00669-1.

Xiao-Xu Wang, Wei-Jie Zhong, Jie-Mei Li, et al. β-catenin initiates peritoneal fibrosis by triggering mitochondrial fission-mediated mesothelial cell senescence fate transition[J/OL]. Military Medical Research, 2025, 12. DOI： 10.1186/s40779-025-00669-1.

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β-catenin initiates peritoneal fibrosis by triggering mitochondrial fission-mediated mesothelial cell senescence fate transition

β-catenin initiates peritoneal fibrosis by triggering mitochondrial fission-mediated mesothelial cell senescence fate transition

DOI：10.1186/s40779-025-00669-1