Cell-free DNA in sepsis: from molecular insights to clinical management

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Cell-free DNA in sepsis: from molecular insights to clinical management

REVIEW | Updated：2026-01-29

- Cell-free DNA in sepsis: from molecular insights to clinical management
- Cell-free DNA in sepsis: from molecular insights to clinical management
- “在脓毒症诊断和治疗领域，无细胞DNA（cfDNA）已成为一种新的生物标志物和分子治疗靶点。专家研究阐明了脓毒症中cfDNA的释放和病理机制，为制定靶向治疗策略奠定了基础。”
- Military Medical Research 2025年12卷
- Affiliations：
  
  1.Department of Burn Surgery, the First Affiliated Hospital of Naval Medical University, Shanghai 200433, China
  2.Research Unit of Key Techniques for Treatment of Burns and Combined Burns and Trauma Injury, Chinese Academy of Medical Sciences, Shanghai 200433, China
- Author bio：
  
  * Shi-Chu Xiao huangzhuoxiao@sohu.com
  Zhao-Fan Xia xiazhaofan_smmu@163.com
  Yong-Jun Zheng zhengyongjun@smmu.edu.cn
- Funds：
  
  the National Key R&D Program of China(2024YFA1108401);the National Nature Science Foundation of China(82372512;82372513;82072170;81930057);the Shanghai Top Priority Research Center Project(2023ZZ02013);the Basic Medical Research Project of Changhai Hospital(2023YQ02);the Changhong Talent Plan of Changhai Hospital, Deep Blue Talent Project of Naval Medical University, Clinical Medical Research of Changhai Hospital(2024LYC06);the CAMS Innovation Fund for Medical Sciences(2019-I2M-5–076);the Major/Key Logistics Research Projects(AHJ24J005;JKBWS23C1018)
- DOI：10.1186/s40779-025-00668-2
  中图分类号：
- 收稿：2025-07-30，
  
  录用：2025-11-01，
  
  网络首发：2025-12-02，
  
  纸质出版：2025
- Accepted：
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Lei Li, Hong-Chao Huang, Yin He, 等. Cell-free DNA in sepsis: from molecular insights to clinical management[J/OL]. Military Medical Research, 2025,12.

Lei Li, Hong-Chao Huang, Yin He, et al. Cell-free DNA in sepsis: from molecular insights to clinical management[J/OL]. Military Medical Research, 2025, 12.
Lei Li, Hong-Chao Huang, Yin He, 等. Cell-free DNA in sepsis: from molecular insights to clinical management[J/OL]. Military Medical Research, 2025,12. DOI： 10.1186/s40779-025-00668-2.

Lei Li, Hong-Chao Huang, Yin He, et al. Cell-free DNA in sepsis: from molecular insights to clinical management[J/OL]. Military Medical Research, 2025, 12. DOI： 10.1186/s40779-025-00668-2.

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Ting Gong

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