Institute of Cancer Neuroscience, Medical Frontier Innovation Research Center, the First Hospital of Lanzhou University, the First Clinical Medical College of Lanzhou University, Lanzhou 730000, China
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Tianjin Key Laboratory of Gene Therapy for Blood Diseases, CAMS Key Laboratory of Gene Therapy for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China
* Wei-Lin Jin ldyy_jinwl@lzu.edu.cn
收稿:2025-03-27,
录用:2025-10-11,
网络首发:2025-10-30,
纸质出版:2026-06
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Qian-Qian Liu, Zi-Kai Dong, Yong-Fei Wang, 等. Reprogramming neural-tumor crosstalk: emerging therapeutic dimensions and targeting strategies[J]. Military Medical Research, 2026,13(6):944-990.
Qian-Qian Liu, Zi-Kai Dong, Yong-Fei Wang, et al. Reprogramming neural-tumor crosstalk: emerging therapeutic dimensions and targeting strategies[J]. Military Medical Research, 2026, 13(6): 944-990.
Qian-Qian Liu, Zi-Kai Dong, Yong-Fei Wang, 等. Reprogramming neural-tumor crosstalk: emerging therapeutic dimensions and targeting strategies[J]. Military Medical Research, 2026,13(6):944-990. DOI: 10.1186/s40779-025-00661-9.
Qian-Qian Liu, Zi-Kai Dong, Yong-Fei Wang, et al. Reprogramming neural-tumor crosstalk: emerging therapeutic dimensions and targeting strategies[J]. Military Medical Research, 2026, 13(6): 944-990. DOI: 10.1186/s40779-025-00661-9.
Cancer neuroscience
an emerging convergent discipline
offers novel insights into the dynamic interplay between the nervous system and cancer progression. Bidirectional signaling between the nervous system and tumors
particularly within the innervated tumor microenvironment (TME)
modulates key cancer hallmarks
including proliferation
immune evasion
angiogenesis
and metastasis. Neural ablation shows heterogeneous outcomes depending on nerve subtype and tumor context
underscoring the importance of nerve-type-specific and context-dependent therapeutic approaches. These mechanistic advances are catalyzing novel therapeutic strate-gies that target neural-TME interactions through the integration of neuroscience and oncology. Here
we highlight recent progress in cancer neuroscience and propose revised therapeutic frameworks aimed at the neuro-innervated TME. These strategies employ interdisciplinary approaches
such as drug repurposing [β-adrenergic receptor (β-AR)blockers
antipsychotics
antidepressants]
and nanotechnology-enabled targeted delivery. Both preclinical and clini-cal data support the potential of neural-targeted therapies to improve precision
circumvent drug resistance
and enhance clinical outcomes. By bridging neuroscience and oncology
this framework delineates a translational pathway for harnessing neural-tumor crosstalk
presenting a promising avenue for advancing cancer therapeutics and improving patient care.
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