Trace element-dictated exosome modules and self-adaptive dual-network hydrogel orchestrate diabetic foot regeneration through complement-mitochondria-autophagy circuitry

Shuang-Qing Wang; Ming-Ji Jin; Ze-Ke Guo; Dong-Ri Shen; Li-Na Jin; Fang Cheng; Yan-Ru Zhao; Teng Liu; Yu-Cai Li; Nuo-Ya Wang; Ling-Qing Chen; Wei Huang; Xiu-Quan Quan; Zhong-Gao Gao

doi:10.1186/s40779-025-00658-4

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Trace element-dictated exosome modules and self-adaptive dual-network hydrogel orchestrate diabetic foot regeneration through complement-mitochondria-autophagy circuitry

RESEARCH | Updated：2026-06-10

- Trace element-dictated exosome modules and self-adaptive dual-network hydrogel orchestrate diabetic foot regeneration through complement-mitochondria-autophagy circuitry
- Trace element-dictated exosome modules and self-adaptive dual-network hydrogel orchestrate diabetic foot regeneration through complement-mitochondria-autophagy circuitry
- Military Medical Research 2026年13卷第4期页码：559-587
- Affiliations：
  
  1.State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sci-ences and Peking Union Medical College, Beijing 100050, China
  2.Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  3.Langfang Kangbao Huitai Biotechnology Co. Ltd, Langfang 065001, Hebei, China
  4.Lan-Jayeon Medical Device Co., Ltd, Beijing 100050, China
  5.Emergency Depart-ment, Yanbian University Hospital, Yanji, Jilin 133000, China
- Author bio：
  
  * Zhong-Gao Gao zggao@imm.ac.cn
- Funds：
  
  the Fundamental Research Funds for the Central Universities, Peking Union Medical College(3332025063);the CAMS Innova-tion Fund for Medical Sciences (CIFMS)(2023-I2M-2–006;China);National Natural Science Foundation of China(82073778;82104106)
- DOI：10.1186/s40779-025-00658-4
  中图分类号：
- 收稿：2025-05-12，
  
  录用：2025-10-02，
  
  网络首发：2025-10-28，
  
  纸质出版：2026-04
- Accepted：
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Shuang-Qing Wang, Ming-Ji Jin, Ze-Ke Guo, 等. Trace element-dictated exosome modules and self-adaptive dual-network hydrogel orchestrate diabetic foot regeneration through complement-mitochondria-autophagy circuitry[J]. Military Medical Research, 2026,13(4):559-587.

Shuang-Qing Wang, Ming-Ji Jin, Ze-Ke Guo, et al. Trace element-dictated exosome modules and self-adaptive dual-network hydrogel orchestrate diabetic foot regeneration through complement-mitochondria-autophagy circuitry[J]. Military Medical Research, 2026, 13(4): 559-587.
Shuang-Qing Wang, Ming-Ji Jin, Ze-Ke Guo, 等. Trace element-dictated exosome modules and self-adaptive dual-network hydrogel orchestrate diabetic foot regeneration through complement-mitochondria-autophagy circuitry[J]. Military Medical Research, 2026,13(4):559-587. DOI： 10.1186/s40779-025-00658-4.

Shuang-Qing Wang, Ming-Ji Jin, Ze-Ke Guo, et al. Trace element-dictated exosome modules and self-adaptive dual-network hydrogel orchestrate diabetic foot regeneration through complement-mitochondria-autophagy circuitry[J]. Military Medical Research, 2026, 13(4): 559-587. DOI： 10.1186/s40779-025-00658-4.

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Trace element-dictated exosome modules and self-adaptive dual-network hydrogel orchestrate diabetic foot regeneration through complement-mitochondria-autophagy circuitry

Trace element-dictated exosome modules and self-adaptive dual-network hydrogel orchestrate diabetic foot regeneration through complement-mitochondria-autophagy circuitry

DOI：10.1186/s40779-025-00658-4