Decreased IL-33 in the brain following repetitive mild traumatic brain injury contributes to cognitive impairment by inhibiting microglial phagocytosis

Ze-Xi Jia; Meng-Tian Guo; Mei-Mei Li; Pan Liao; Bo Yan; Wei Zhang; Fang-Yuan Cheng; Ya-Ru Liu; Zi-Han Zhang; Cheng Wei; Jie Zhou; Fang-Lian Chen; Ping Lei; Xin-Tong Ge

doi:10.1186/s40779-025-00631-1

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Decreased IL-33 in the brain following repetitive mild traumatic brain injury contributes to cognitive impairment by inhibiting microglial phagocytosis

RESEARCH | Updated：2026-03-26

- Decreased IL-33 in the brain following repetitive mild traumatic brain injury contributes to cognitive impairment by inhibiting microglial phagocytosis
- Decreased IL-33 in the brain following repetitive mild traumatic brain injury contributes to cognitive impairment by inhibiting microglial phagocytosis
- Military Medical Research 2026年13卷第1期页码：24-42
- Affiliations：
  
  1.Department of Geriatrics, Tianjin Medical University General Hospital, Tianjin 300052, China
  2.Tianjin Geriatrics Institute, Tianjin Medical University General Hospital, Tianjin 300052, China
  3.Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052, China
  4.Department of Internal Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100054, China
  5.School of Medicine, Nankai University, Tianjin 300071, China
  6.Department of Oncology-Pathology, Karolinska Institute, 10339 Stock-holm, Sweden
  7.Department of Immunology, School of Basic Medical Sci-ences, Tianjin Medical University, Tianjin 300070, China
- Author bio：
  
  * Fang-Lian Chen chenfanglian1976@tmu.edu.cn
  Ping Lei leiping1974@tmu.edu.cn
  Xin-Tong Ge xge@tmu.edu.cn
- Funds：
  
  the National Natural Science Foundation of China(82271401;82071394);the Tianjin Health Research Project(TJWJ2024RC002)
- DOI：10.1186/s40779-025-00631-1
  中图分类号：
- 收稿：2024-11-06，
  
  录用：2025-07-16，
  
  网络首发：2025-08-05，
  
  纸质出版：2026-01
- Accepted：
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Ze-Xi Jia, Meng-Tian Guo, Mei-Mei Li, 等. Decreased IL-33 in the brain following repetitive mild traumatic brain injury contributes to cognitive impairment by inhibiting microglial phagocytosis[J]. Military Medical Research, 2026,13(1):24-42.

Ze-Xi Jia, Meng-Tian Guo, Mei-Mei Li, et al. Decreased IL-33 in the brain following repetitive mild traumatic brain injury contributes to cognitive impairment by inhibiting microglial phagocytosis[J]. Military Medical Research, 2026, 13(1): 24-42.
Ze-Xi Jia, Meng-Tian Guo, Mei-Mei Li, 等. Decreased IL-33 in the brain following repetitive mild traumatic brain injury contributes to cognitive impairment by inhibiting microglial phagocytosis[J]. Military Medical Research, 2026,13(1):24-42. DOI： 10.1186/s40779-025-00631-1.

Ze-Xi Jia, Meng-Tian Guo, Mei-Mei Li, et al. Decreased IL-33 in the brain following repetitive mild traumatic brain injury contributes to cognitive impairment by inhibiting microglial phagocytosis[J]. Military Medical Research, 2026, 13(1): 24-42. DOI： 10.1186/s40779-025-00631-1.

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Decreased IL-33 in the brain following repetitive mild traumatic brain injury contributes to cognitive impairment by inhibiting microglial phagocytosis

Decreased IL-33 in the brain following repetitive mild traumatic brain injury contributes to cognitive impairment by inhibiting microglial phagocytosis

DOI：10.1186/s40779-025-00631-1