Glucocorticoids trigger muscle-liver crosstalk to attenuate acute liver injury and promote liver regeneration via the FGF6-FGFBP1 axis

Yue-Jie Xu; Cai-Zhi Liu; Ying Chen; Lan-Xin Li; Bo Xu; Ling-Xin You; Mei-Yao Meng; Xin Li; Hong Zhang; Qiu-Rong Ding; Rong Zhang; Xin-Ran Ma; Xiao-Hua Chen; Cheng Hu

doi:10.1186/s40779-025-00618-y

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Glucocorticoids trigger muscle-liver crosstalk to attenuate acute liver injury and promote liver regeneration via the FGF6-FGFBP1 axis

RESEARCH | Updated：2026-01-27

- Glucocorticoids trigger muscle-liver crosstalk to attenuate acute liver injury and promote liver regeneration via the FGF6-FGFBP1 axis
- Glucocorticoids trigger muscle-liver crosstalk to attenuate acute liver injury and promote liver regeneration via the FGF6-FGFBP1 axis
- “在急性肝损伤（ALI）研究领域，专家们已经确定了一种分子机制，该机制通过FGF6-FGFBP1/FGF5轴通过肌肉-肝脏串扰启动和维持肝脏再生，为ALI提供了潜在的治疗靶点和治疗策略。”
- Military Medical Research 2025年12卷第12期页码：1860-1882
- Affiliations：
  
  1.Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China
  2.Jinzhou Medical University Graduate Training Base (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine), Jinzhou 121001, Liaoning, China
  3.Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China
  4.Research Direction of New Microecological Technology, Jinan Microecological Biomedicine Shandong Laboratory, Jinan 250000, China
  5.CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China
  6.Department of Infectious Diseases, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China
  7.Department of Endocrinology and Metabolism, Fengxian Central Hospital Affiliated to Southern Medical University, Shanghai 201499, China
- Author bio：
  
  * Cai-Zhi Liu adaica@sjtu.edu.cn
  Xiao-Hua Chen chenxiaohua2000@163.com
  Cheng Hu alfredhc@sjtu.edu.cn
- Funds：
  
  the NSFC Distinguished Young Scholars Fund(82325010);the National Natural Science Foundation of China(82370874);the Innovative Research Team of High-level Local Universities in Shanghai(SHSMU-ZDCX20212700);the Major Natural Science Project of the Scientific Research and Innovation Plan of Shanghai Municipal Commission of Education(2023ZKZD17);the Shanghai Research Center for Endocrine and Metabolic Diseases(2022ZZ01002);the Shanghai Key Discipline of Public Health Grants Award(GWVI-11.1–20);the Basic Scientific Research Project (General Cultivation Program) of Shanghai Sixth People’s Hospital(ynms202203)
- DOI：10.1186/s40779-025-00618-y
  中图分类号：
- 收稿：2024-12-23，
  
  录用：2025-05-28，
  
  网络首发：2025-07-21，
  
  纸质出版：2025-12
- Accepted：
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Yue-Jie Xu, Cai-Zhi Liu, Ying Chen, 等. Glucocorticoids trigger muscle-liver crosstalk to attenuate acute liver injury and promote liver regeneration via the FGF6-FGFBP1 axis[J]. Military Medical Research, 2025,12(12):1860-1882.

Yue-Jie Xu, Cai-Zhi Liu, Ying Chen, et al. Glucocorticoids trigger muscle-liver crosstalk to attenuate acute liver injury and promote liver regeneration via the FGF6-FGFBP1 axis[J]. Military Medical Research, 2025, 12(12): 1860-1882.
Yue-Jie Xu, Cai-Zhi Liu, Ying Chen, 等. Glucocorticoids trigger muscle-liver crosstalk to attenuate acute liver injury and promote liver regeneration via the FGF6-FGFBP1 axis[J]. Military Medical Research, 2025,12(12):1860-1882. DOI： 10.1186/s40779-025-00618-y.

Yue-Jie Xu, Cai-Zhi Liu, Ying Chen, et al. Glucocorticoids trigger muscle-liver crosstalk to attenuate acute liver injury and promote liver regeneration via the FGF6-FGFBP1 axis[J]. Military Medical Research, 2025, 12(12): 1860-1882. DOI： 10.1186/s40779-025-00618-y.

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Glucocorticoids trigger muscle-liver crosstalk to attenuate acute liver injury and promote liver regeneration via the FGF6-FGFBP1 axis

Glucocorticoids trigger muscle-liver crosstalk to attenuate acute liver injury and promote liver regeneration via the FGF6-FGFBP1 axis

DOI：10.1186/s40779-025-00618-y