GSTM1 suppresses cardiac fibrosis post-myocardial infarction through inhibiting lipid peroxidation and ferroptosis

Kai-Jie Chen; Yue Zhang; Xin-Yi Zhu; Shuo Yu; Yao Xie; Cheng-Jiang Jin; Yi-Min Shen; Si-Yu Zhou; Xiao-Ce Dai; Sheng-An Su; Lan Xie; Zheng-Xing Huang; Hui Gong; Mei-Xiang Xiang; Hong Ma

doi:10.1186/s40779-025-00610-6

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GSTM1 suppresses cardiac fibrosis post-myocardial infarction through inhibiting lipid peroxidation and ferroptosis

RESEARCH | Updated：2025-12-13

- GSTM1 suppresses cardiac fibrosis post-myocardial infarction through inhibiting lipid peroxidation and ferroptosis
- GSTM1 suppresses cardiac fibrosis post-myocardial infarction through inhibiting lipid peroxidation and ferroptosis
- “在心肌梗死后纤维化领域，本研究将GSTM1确定为成纤维细胞活化和心脏纤维化的关键抑制剂，突出了其通过氧化还原调节靶向铁下垂的能力。xx专家建立了xx系统/探索了xx课题/验证了xx猜想，为解决xx问题提供了解决方案/为xx研究开辟了新的方向/为xx系统的建设奠定了基础。”
- Military Medical Research 2025年12卷第10期页码：1520-1541
- Affiliations：
  
  1.Department of Cardiology, The Second Affiliated Hospital, School of Medicine, State Key Laboratory of Transvascular Implantation Devices, Cardiovascular Key Laboratory of Zhejiang Province, Zhejiang University, Hangzhou 310009, China
  2.Department of Anesthesiology, The Second Affili-ated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China
  3.College of Computer Science and Technology, Zhejiang University, Hangzhou 310009, China
  4.Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China
- Author bio：
  
  * Hui Gong gonghui2005@fudan.edu.cn
  Mei-Xiang Xiang xiangmx@zju.edu.cn
  Hong Ma hong_ma@zju.edu.cn
- Funds：
  
  the National Natural Science Foundation of China(82270386;82070252;8207025);the Zhejiang Provincial Medical and Health Science and Technology Plan(2023RC020);the Zhejiang Provincial Natural Science Foundation(LR21H020001)
- DOI：10.1186/s40779-025-00610-6
  中图分类号：
- 收稿：2024-10-26，
  
  录用：2025-04-25，
  
  网络首发：2025-05-31，
  
  纸质出版：2025-10
- Accepted：
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Kai-Jie Chen, Yue Zhang, Xin-Yi Zhu, 等. GSTM1 suppresses cardiac fibrosis post-myocardial infarction through inhibiting lipid peroxidation and ferroptosis[J]. Military Medical Research, 2025,12(10):1520-1541.

Kai-Jie Chen, Yue Zhang, Xin-Yi Zhu, et al. GSTM1 suppresses cardiac fibrosis post-myocardial infarction through inhibiting lipid peroxidation and ferroptosis[J]. Military Medical Research, 2025, 12(10): 1520-1541.
Kai-Jie Chen, Yue Zhang, Xin-Yi Zhu, 等. GSTM1 suppresses cardiac fibrosis post-myocardial infarction through inhibiting lipid peroxidation and ferroptosis[J]. Military Medical Research, 2025,12(10):1520-1541. DOI： 10.1186/s40779-025-00610-6.

Kai-Jie Chen, Yue Zhang, Xin-Yi Zhu, et al. GSTM1 suppresses cardiac fibrosis post-myocardial infarction through inhibiting lipid peroxidation and ferroptosis[J]. Military Medical Research, 2025, 12(10): 1520-1541. DOI： 10.1186/s40779-025-00610-6.

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GSTM1 suppresses cardiac fibrosis post-myocardial infarction through inhibiting lipid peroxidation and ferroptosis

GSTM1 suppresses cardiac fibrosis post-myocardial infarction through inhibiting lipid peroxidation and ferroptosis

DOI：10.1186/s40779-025-00610-6