High-salt-driven gut microbiota dysfunction aggravates prostatitis by promoting AHR/SGK1/FOXO1 axis-mediated Th17 cell differentiation

Jing Chen; Rui Feng; Bin-Bin Gong; Wei-Kang Wu; Bang-Shun Dai; Rui Tan; Wen-Long Xu; Tong Meng; Xiao-Bin Wang; Yun-Zheng Xiao; Cheng Yang; Li Zhang; Chao-Zhao Liang

doi:10.1186/s40779-025-00607-1

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High-salt-driven gut microbiota dysfunction aggravates prostatitis by promoting AHR/SGK1/FOXO1 axis-mediated Th17 cell differentiation

RESEARCH | Updated：2025-12-13

- High-salt-driven gut microbiota dysfunction aggravates prostatitis by promoting AHR/SGK1/FOXO1 axis-mediated Th17 cell differentiation
- High-salt-driven gut microbiota dysfunction aggravates prostatitis by promoting AHR/SGK1/FOXO1 axis-mediated Th17 cell differentiation
- “在慢性前列腺炎/慢性盆腔疼痛综合征（CP/CPPS）领域，专家们已经证实了高盐饮食（HSD）的摄入会促进CD4+T细胞分化为促炎性T辅助细胞17（Th17），从而加重CP/CPPS的推测。这一发现为CP/CPPS提供了潜在的治疗靶点。”
- Military Medical Research 2025年12卷第10期页码：1501-1519
- Affiliations：
  
  1.Department of Urology, the First Affiliated Hospital of Anhui Medical University, Institute of Urology, and Anhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Anhui Medical University, Hefei 230022, China
  2.Department of Urology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  3.Department of Urology, Southern University of Science and Technology Hospital, Shenzhen 518055, Guangdong, China
  4.Center for Scientific Research of the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China
- Author bio：
  
  * Cheng Yang yang_cheng@ahmu.edu.cn
  Li Zhang lzhang@ahmu.edu.cn
  Chao-Zhao Liang liang_chaozhao@ahmu.edu.cn
- Funds：
  
  the National Natural Science Foundation of China(82300872;82170787);the Anhui Provincial Natural Science Foundation(2408085Y038);the Supporting Projects for Innovative Leading Talents(T000529);the Distinguished Young Scholar of Anhui Colleges(2021-108-10);the Science Foundation for Outstanding Young Scholar of Anhui Colleges(2022AH020073);the Sanming Project of Medicine in Shenzhen Nanshan(SZSM20210300)
- DOI：10.1186/s40779-025-00607-1
  中图分类号：
- 收稿：2024-08-14，
  
  录用：2025-04-11，
  
  网络首发：2025-05-19，
  
  纸质出版：2025-10
- Accepted：
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Jing Chen, Rui Feng, Bin-Bin Gong, 等. High-salt-driven gut microbiota dysfunction aggravates prostatitis by promoting AHR/SGK1/FOXO1 axis-mediated Th17 cell differentiation[J]. Military Medical Research, 2025,12(10):1501-1519.

Jing Chen, Rui Feng, Bin-Bin Gong, et al. High-salt-driven gut microbiota dysfunction aggravates prostatitis by promoting AHR/SGK1/FOXO1 axis-mediated Th17 cell differentiation[J]. Military Medical Research, 2025, 12(10): 1501-1519.
Jing Chen, Rui Feng, Bin-Bin Gong, 等. High-salt-driven gut microbiota dysfunction aggravates prostatitis by promoting AHR/SGK1/FOXO1 axis-mediated Th17 cell differentiation[J]. Military Medical Research, 2025,12(10):1501-1519. DOI： 10.1186/s40779-025-00607-1.

Jing Chen, Rui Feng, Bin-Bin Gong, et al. High-salt-driven gut microbiota dysfunction aggravates prostatitis by promoting AHR/SGK1/FOXO1 axis-mediated Th17 cell differentiation[J]. Military Medical Research, 2025, 12(10): 1501-1519. DOI： 10.1186/s40779-025-00607-1.

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High-salt-driven gut microbiota dysfunction aggravates prostatitis by promoting AHR/SGK1/FOXO1 axis-mediated Th17 cell differentiation

High-salt-driven gut microbiota dysfunction aggravates prostatitis by promoting AHR/SGK1/FOXO1 axis-mediated Th17 cell differentiation

DOI：10.1186/s40779-025-00607-1