Targeting RTKs/nRTKs as promising therapeutic strategies for the treatment of triple-negative breast cancer: evidence from clinical trials

Kasshish Mehta; Mangala Hegde; Sosmitha Girisa; Ravichandran Vishwa; Mohammed S. Alqahtani; Mohamed Abbas; Mehdi Shakibaei; Gautam Sethi; Ajaikumar B. Kunnumakkara

doi:10.1186/s40779-024-00582-z

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Targeting RTKs/nRTKs as promising therapeutic strategies for the treatment of triple-negative breast cancer: evidence from clinical trials

REVIEW | Updated：2025-12-13

- Targeting RTKs/nRTKs as promising therapeutic strategies for the treatment of triple-negative breast cancer: evidence from clinical trials
- Targeting RTKs/nRTKs as promising therapeutic strategies for the treatment of triple-negative breast cancer: evidence from clinical trials
- “在癌症三阴性治疗领域，近年来的研究取得了重大进展。专家们已经证实，靶向酪氨酸激酶（TKs）及其受体可以提供对抗TNBC的解决方案，为构建精准医学系统奠定了基础。”
- MMR 2025年12卷第8期页码：1258-1282
- Affiliations：
  
  1.Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Guwahati, Assam 781039, India
  2.Radiological Sciences Department, College of Applied Medical Sciences, King Khalid University, 61421 Abha, Saudi Arabia
  3.BioImaging Unit, Space Research Centre, Michael Atiyah Building, University of Leicester, Leicester LE1 7RH, UK
  4.Electrical Engineering Department, College of Engineering, King Khalid University, 61421 Abha, Saudi Arabia
  5.Department of Human-Anatomy, Musculoskeletal Research Group and Tumor Biology, Chair of Vegetative Anatomy, Institute of Anatomy, Ludwig-Maximilian-University, 80336 Munich, Germany
  6.Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore
  7.NUS Centre for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117699, Singapore
- Author bio：
  
  * Gautam Sethi phcgs@nus.edu.sg
  Ajaikumar B. Kunnumakkara kunnumakkara@iitg.ac.in
- Funds：
  
  Department of Biotechnology (DBT);Government of India(BT/556/NE/U-Excel/)
- DOI：10.1186/s40779-024-00582-z
  中图分类号：
- 收稿：2023-10-19，
  
  录用：2024-11-08，
  
  网络首发：2024-12-12，
  
  纸质出版：2025-08
- Accepted：
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Targeting RTKs/nRTKs as promising therapeutic strategies for the treatment of triple-negative breast cancer: evidence from clinical trials[J]. MMR, 2025,12(8):1258-1282.

Kasshish Mehta, Mangala Hegde, Sosmitha Girisa, et al. Targeting RTKs/nRTKs as promising therapeutic strategies for the treatment of triple-negative breast cancer: evidence from clinical trials[J]. Military Medical Research, 2025, 12(8): 1258-1282.
Targeting RTKs/nRTKs as promising therapeutic strategies for the treatment of triple-negative breast cancer: evidence from clinical trials[J]. MMR, 2025,12(8):1258-1282. DOI： 10.1186/s40779-024-00582-z.

Kasshish Mehta, Mangala Hegde, Sosmitha Girisa, et al. Targeting RTKs/nRTKs as promising therapeutic strategies for the treatment of triple-negative breast cancer: evidence from clinical trials[J]. Military Medical Research, 2025, 12(8): 1258-1282. DOI： 10.1186/s40779-024-00582-z.

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Targeting RTKs/nRTKs as promising therapeutic strategies for the treatment of triple-negative breast cancer: evidence from clinical trials

Targeting RTKs/nRTKs as promising therapeutic strategies for the treatment of triple-negative breast cancer: evidence from clinical trials

DOI：10.1186/s40779-024-00582-z