Bioactive peptides and proteins for tissue repair: microenvironment modulation, rational delivery, and clinical potential

Zhuo-Wen Hao; Zhe-Yuan Zhang; Ze-Pu Wang; Ying Wang; Jia-Yao Chen; Tian-Hong Chen; Guang Shi; Han-Ke Li; Jun-Wu Wang; Min-Chao Dong; Li Hong; Jing-Feng Li

doi:10.1186/s40779-024-00576-x

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Bioactive peptides and proteins for tissue repair: microenvironment modulation, rational delivery, and clinical potential

REVIEW | Updated：2025-12-13

- Bioactive peptides and proteins for tissue repair: microenvironment modulation, rational delivery, and clinical potential
- Bioactive peptides and proteins for tissue repair: microenvironment modulation, rational delivery, and clinical potential
- “在组织修复领域，生物活性肽和蛋白质（BAPP）作为治疗剂显示出巨大的潜力。本文总结了BAPP调节组织修复微环境的机制，以及各种递送平台结合BAPP进行有效组织修复的机制。它还讨论了BAPP在促进各种类型组织修复方面的临床潜力。”
- MMR 2025年12卷第8期页码：1194-1257
- Affiliations：
  
  1.Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
  2.Department of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan 430060, China
- Author bio：
  
  * Li Hong dr_hongli@whu.edu.cn
  Jing-Feng Li jingfengli@whu.edu.cn
- Funds：
  
  the National Natural Science Foundation of China(82372405;81871752);the Key Research and Development Program of Hubei Province(2022BCA052);the Key Research and Development Program of Wuhan City(2024020702030105);the Fundamental Research Funds for the Central Universities(2042023kf0199);the Translational Medicine and Inter-disciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University(ZNJC202014)
- DOI：10.1186/s40779-024-00576-x
  中图分类号：
- 收稿：2024-04-12，
  
  录用：2024-10-25，
  
  网络首发：2024-12-05，
  
  纸质出版：2025-08
- Accepted：
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Bioactive peptides and proteins for tissue repair: microenvironment modulation, rational delivery, and clinical potential[J]. MMR, 2025,12(8):1194-1257.

Zhuo-Wen Hao, Zhe-Yuan Zhang, Ze-Pu Wang, et al. Bioactive peptides and proteins for tissue repair: microenvironment modulation, rational delivery, and clinical potential[J]. Military Medical Research, 2025, 12(8): 1194-1257.
Bioactive peptides and proteins for tissue repair: microenvironment modulation, rational delivery, and clinical potential[J]. MMR, 2025,12(8):1194-1257. DOI： 10.1186/s40779-024-00576-x.

Zhuo-Wen Hao, Zhe-Yuan Zhang, Ze-Pu Wang, et al. Bioactive peptides and proteins for tissue repair: microenvironment modulation, rational delivery, and clinical potential[J]. Military Medical Research, 2025, 12(8): 1194-1257. DOI： 10.1186/s40779-024-00576-x.

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Bioactive peptides and proteins for tissue repair: microenvironment modulation, rational delivery, and clinical potential

Bioactive peptides and proteins for tissue repair: microenvironment modulation, rational delivery, and clinical potential

DOI：10.1186/s40779-024-00576-x