Mechanism of lactic acidemia-promoted pulmonary endothelial cells death in sepsis: role for CIRP-ZBP1-PANoptosis pathway

Ting Gong; Qing-De Wang; Patricia A. Loughran; Yue-Hua Li; Melanie J. Scott; Timothy R. Billiar; You-Tan Liu; Jie Fan

doi:10.1186/s40779-024-00574-z

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Mechanism of lactic acidemia-promoted pulmonary endothelial cells death in sepsis: role for CIRP-ZBP1-PANoptosis pathway

RESEARCH | Updated：2025-12-13

- Mechanism of lactic acidemia-promoted pulmonary endothelial cells death in sepsis: role for CIRP-ZBP1-PANoptosis pathway
- Mechanism of lactic acidemia-promoted pulmonary endothelial cells death in sepsis: role for CIRP-ZBP1-PANoptosis pathway
- “在脓毒症诱导的急性肺损伤领域，一种新的途径已经被揭示。专家研究表明，脓毒症期间乳酸的积累促进了巨噬细胞来源的细胞外CIRP的释放，这介导了ZBP1依赖性肺血管内皮细胞PANoptosis，加剧了ALI。这一发现为脓毒症相关肺部并发症的分子机制提供了新的见解，并提供了潜在的新治疗策略。”
- MMR 2025年12卷第7期页码：1023-1045
- Affiliations：
  
  1.Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
  2.Department of Anesthesiology, Shenzhen Hospital of Southern Medical University, Shenzhen 518110, Guangdong, China
  3.McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
  4.Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
  5.Research and Development, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA
- Author bio：
  
  * tinggong@pitt.edu
  youtanliuhao@163.com
  jif7@pitt.edu
- Funds：
  
  the USA VA(1I01BX004838;IK6BX006297);the Shenzhen Science and Technology Program(JCYJ20230807142311024)
- DOI：10.1186/s40779-024-00574-z
  中图分类号：
- 纸质出版：2025-07
- Accepted：
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Mechanism of lactic acidemia-promoted pulmonary endothelial cells death in sepsis: role for CIRP-ZBP1-PANoptosis pathway[J]. MMR, 2025,12(7):1023-1045.

Cite this article as: Gong T, Wang QD, Loughran PA, Li YH, Scott MJ, Billiar TR, et al. Mechanism of lactic acidemia-promoted pulmonary endothelial cells death in sepsis: role for CIRP-ZBP1-PANoptosis pathway. Mil Med Res. 2024;11(1):71.
Mechanism of lactic acidemia-promoted pulmonary endothelial cells death in sepsis: role for CIRP-ZBP1-PANoptosis pathway[J]. MMR, 2025,12(7):1023-1045. DOI： 10.1186/s40779-024-00574-z.

Cite this article as: Gong T, Wang QD, Loughran PA, Li YH, Scott MJ, Billiar TR, et al. Mechanism of lactic acidemia-promoted pulmonary endothelial cells death in sepsis: role for CIRP-ZBP1-PANoptosis pathway. Mil Med Res. 2024;11(1):71. DOI： 10.1186/s40779-024-00574-z.

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Mechanism of lactic acidemia-promoted pulmonary endothelial cells death in sepsis: role for CIRP-ZBP1-PANoptosis pathway

Mechanism of lactic acidemia-promoted pulmonary endothelial cells death in sepsis: role for CIRP-ZBP1-PANoptosis pathway

DOI：10.1186/s40779-024-00574-z