Hippocampal PACAP signaling activation triggers a rapid antidepressant response

Hai-Lou Zhang; Yan Sun; Zhang-Jie Wu; Ying Yin; Rui-Yi Liu; Ji-Chun Zhang; Zhang-Jin Zhang; Suk-Yu Yau; Hao-Xin Wu; Ti-Fei Yuan; Li Zhang; Miroslav Adzic; Gang Chen

doi:10.1186/s40779-024-00548-1

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Hippocampal PACAP signaling activation triggers a rapid antidepressant response

RESEARCH | Updated：2025-12-13

- Hippocampal PACAP signaling activation triggers a rapid antidepressant response
- Hippocampal PACAP signaling activation triggers a rapid antidepressant response
- “一项研究报告了快速抗抑郁机制的前沿研究，深入探讨了神经肽PACAP在介导对抑郁症治疗的快速反应中的作用。这项研究涉及446只小鼠和各种行为和分子检测，揭示了激活海马PACAP信号通过调节CaMKⅡ抑制控制的eEF2-mTOR BDNF信号来触发快速的抗抑郁作用，为抑郁症提供了一种新的治疗方法。”
- MMR 2025年12卷第4期页码：512-527
- Affiliations：
  
  1.Interdisciplinary Institute for Personalized Medicine in Brain Disorders, Jinan University, Guangzhou 510632, China
  2.Departments of Psychiatry & Clinical and Translational Institute of Psychiatric Disorders, First Affiliated Hospital of Jinan University, Guangzhou 510632, China
  3.The Guangdong-Hongkong-Macau Joint Laboratory of Traditional Chinese Medicine Regulation of Brain-Periphery Homeostasis and Comprehensive Health, Guangzhou 510632, China
  4.Key Laboratory of Integrative Biomedicine for Brain Diseases, School of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China
  5.School of Medicine, Jinan University, Guangzhou 510632, China
  6.School of Chinese Medicine, LKS Faculty of Medicine, the University of Hong Kong, Hong Kong 999077, China
  7.Department of Rehabilitation Sciences, Hong Kong Polytechnic University, Hong Kong 999077, China
  8.Shanghai Mental Health Center, Shanghai 200030, China
  9.Key Laboratory of Central CNS Regeneration (Ministry of Education), Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China
  10."Vinča" Institute of Nuclear Sciences, Laboratory of Molecular Biology and Endocrinology 090, University of Belgrade, 11001 Belgrade, Serbia
- Author bio：
  
  *chengang@jnu.edu.cn
- Funds：
  
  the National Key Research and Development Program of China(2022YFE0201000);the National Natural Science Foundation of China(82174002;82104416;82204652);the High-Level University Development Program of Guangdong Province;the Guangzhou Key Science and Technology Research and Development Project(202206010109)
- DOI：10.1186/s40779-024-00548-1
  中图分类号：
- 纸质出版：2025-04
- Accepted：
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Hippocampal PACAP signaling activation triggers a rapid antidepressant response[J]. MMR, 2025,12(4):512-527.

Cite this article as: Zhang HL, Sun Y, Wu ZJ, Yin Y, Liu RY, Zhang JC, et al. Hippocampal PACAP signaling activation triggers a rapid antidepressant response. Mil Med Res. 2024;11(1):49.
Hippocampal PACAP signaling activation triggers a rapid antidepressant response[J]. MMR, 2025,12(4):512-527. DOI： 10.1186/s40779-024-00548-1.

Cite this article as: Zhang HL, Sun Y, Wu ZJ, Yin Y, Liu RY, Zhang JC, et al. Hippocampal PACAP signaling activation triggers a rapid antidepressant response. Mil Med Res. 2024;11(1):49. DOI： 10.1186/s40779-024-00548-1.

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Hippocampal PACAP signaling activation triggers a rapid antidepressant response

Hippocampal PACAP signaling activation triggers a rapid antidepressant response

DOI：10.1186/s40779-024-00548-1