Genome-wide enhancer RNA profiling adds molecular links between genetic variation and human cancers

Yi-Min Cai; Ze-Qun Lu; Bin Li; Jin-Yu Huang; Ming Zhang; Can Chen; Lin-Yun Fan; Qian-Ying Ma; Chun-Yi He; Shuo-Ni Chen; Yuan Jiang; Yan-Min Li; Cai-Bo Ning; Fu-Wei Zhang; Wen-Zhuo Wang; Yi-Zhuo Liu; Heng Zhang; Meng Jin; Xiao-Yang Wang; Jin-Xin Han; Zhen Xiong; Ming Cai; Chao-Qun Huang; Xiao-Jun Yang; Xu Zhu; Ying Zhu; Xiao-Ping Miao; Shao-Kai Zhang; Yong-Chang Wei; Jian-Bo Tian

doi:10.1186/s40779-024-00539-2

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Genome-wide enhancer RNA profiling adds molecular links between genetic variation and human cancers

RESEARCH | Updated：2025-12-13

- Genome-wide enhancer RNA profiling adds molecular links between genetic variation and human cancers
- Genome-wide enhancer RNA profiling adds molecular links between genetic variation and human cancers
- “在癌症研究领域，对增强子RNA定量性状基因座（eRNAQTL）进行了全面分析，在30种癌症类型中鉴定了300112个eRNAQTLs。专家建立了CancereRNAQTL系统，为解决癌症遗传性问题提供了解决方案，并为构建基于eRNA的治疗策略奠定了基础。”
- MMR 2025年12卷第4期页码：488-511
- Affiliations：
  
  1.Department of Epidemiology and Biostatistics, School of Public Health, Research Center of Public Health, Renmin Hospital of Wuhan University, Tai-Kang Center for Life and Medical Sciences, Wuhan University, Wuhan 430071, China
  2.Department of Gastrointestinal Oncology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430071, China
  3.Department of Cancer Epidemiology, Henan Engineering Research Center of Cancer Prevention and Control, Henan International Joint Laboratory of Cancer Prevention, the Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450008, China
  4.Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
  5.Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
  6.Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430071, China
  7.Department of Gastrointestinal Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China
  8.Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
  9.Jiangsu Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing 211166, China
  10.Department of Gastrointestinal Oncology, Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
- Author bio：
  
  *xpmiao@whu.edu.cn;
  shaokaizhang@126.com;
  weiyongchang@whu.edu.cn;
  tianjb@whu.edu.cn
- Funds：
  
  the National Science Fund for Excellent Young Scholars(NSFC-82322058);the Program of National Natural Science Foundation of China(NSFC-82103929;NSFC-82273713);the Young Elite Scientists Sponsorship Program by CAST(2022QNRC001);the National Science Fund for Distinguished Young Scholars of Hubei Province of China(2023AFA046);the Fundamental Research Funds for the Central Universities(WHU:2042022kf1205);the Knowledge Innovation Program of Wuhan(whkxjsj011;2023020201010073);the Science and Technology Innovation Seed Fund of Zhongnan Hospital of Wuhan University(znpy2019060);the Distinguished Young Scholars of China(NSFC-81925032);the Key Program of National Natural Science Foundation of China(NSFC-82130098);the Fundamental Research Funds for the Central Universities(2042022rc0026;2042023kf1005);the Youth Program of National Natural Science Foundation of China(NSFC-82003547);the Program of Health Commission of Hubei Province(WJ2023M045);Fundamental Research Funds for the Central Universities(WHU: 2042022kf1031)
- DOI：10.1186/s40779-024-00539-2
  中图分类号：
- 纸质出版：2025-04
- Accepted：
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Genome-wide enhancer RNA profiling adds molecular links between genetic variation and human cancers[J]. MMR, 2025,12(4):488-511.

Cite this article as: Cai YM, Lu ZQ, Li B, Huang JY, Zhang M, Chen C, et al. Genome-wide enhancer RNA profiling adds molecular links between genetic variation and human cancers. Mil Med Res. 2024;11(1):36.
Genome-wide enhancer RNA profiling adds molecular links between genetic variation and human cancers[J]. MMR, 2025,12(4):488-511. DOI： 10.1186/s40779-024-00539-2.

Cite this article as: Cai YM, Lu ZQ, Li B, Huang JY, Zhang M, Chen C, et al. Genome-wide enhancer RNA profiling adds molecular links between genetic variation and human cancers. Mil Med Res. 2024;11(1):36. DOI： 10.1186/s40779-024-00539-2.

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Genome-wide enhancer RNA profiling adds molecular links between genetic variation and human cancers

Genome-wide enhancer RNA profiling adds molecular links between genetic variation and human cancers

DOI：10.1186/s40779-024-00539-2