Advancing skeletal health and disease research with single-cell RNA sequencing

Peng Lin; Yi-Bo Gan; Jian He; Si-En Lin; Jian-Kun Xu; Liang Chang; Li-Ming Zhao; Jun Zhu; Liang Zhang; Sha Huang; Ou Hu; Ying-Bo Wang; Huai-Jian Jin; Yang-Yang Li; Pu-Lin Yan; Lin Chen; Jian-Xin Jiang; Peng Liu

doi:10.1186/s40779-024-00538-3

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Advancing skeletal health and disease research with single-cell RNA sequencing

REVIEW | Updated：2025-12-13

- Advancing skeletal health and disease research with single-cell RNA sequencing
- Advancing skeletal health and disease research with single-cell RNA sequencing
- “在骨科领域，一项全面的综述提出了一种从骨骼组织中获得高质量单细胞的简化方法，并概述了骨骼研究中使用的现有单细胞RNA测序技术以及实用的生物信息学分析管道。这项研究为发现新的治疗靶点铺平了道路，这些靶点为患有各种骨骼疾病的患者提供了潜在的益处。”
- MMR 2025年12卷第2期页码：285-310
- Affiliations：
  
  1.Department of Spine Surgery, Center of Orthopedics, State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical University, Chongqing 400042, China
  2.Pancreatic Injury and Repair Key Laboratory of Sichuan Province, the General Hospital of Western Theater Command, Chengdu 610031, China
  3.Musculoskeletal Research Laboratory, Department of Orthopaedics & Traumatology, Faculty of Medicine, the Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR 999077, China
  4.Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Sacramento, CA 94305, USA
  5.Center of Bone Metabolism and Repair, State Key Laboratory of Trauma and Chemical Poisoning, Trauma Center, Research Institute of Surgery, Laboratory for the Prevention and Rehabilitation of Military Training Related Injuries, Daping Hospital, Army Medical University, Chongqing 400042, China
  6.Wound Trauma Medical Center, State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical University, Chongqing 400042, China
- Author bio：
  
  *jiangjx@cta.cq.cn;
  liupengd@tmmu.edu.cn
- Funds：
  
  the National Key Research and Development Program of China(2022YFA1103202);the National Natural Science Foundation of China(82272507;32270887;32200654);the Natural Science Foundation of Chongqing(CSTB2023NSCQ-ZDJO008);the Postdoctoral Innovative Talent Support Program(BX20220397);the Independent Research Project of State Key Laboratory of Trauma and Chemical Poisoning(SFLKF202201);the Project for Enhancing Innovation of Army Medical University(2023X1839);the Talent Innovation Training Program at the Army Medical Center(ZXZYTSYS09);the General Hospital of Western Theater Command Research Project(2021-XZYG-B10);the University Grants Committee, Research Grants Council of Hong Kong, China(14113723;N_CUHK472/22;C7030-18G;T13-402/17-N;AoE/M-402/20)
- DOI：10.1186/s40779-024-00538-3
  中图分类号：
- 纸质出版：2025-02
- Accepted：
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Advancing skeletal health and disease research with single-cell RNA sequencing[J]. MMR, 2025,12(2):285-310.

Cite this article as: Lin P, Gan YB, He J, Lin SE, Xu JK, Chang L, et al. Advancing skeletal health and disease research with single-cell RNA sequencing. Mil Med Res. 2024;11(1):33.
Advancing skeletal health and disease research with single-cell RNA sequencing[J]. MMR, 2025,12(2):285-310. DOI： 10.1186/s40779-024-00538-3.

Cite this article as: Lin P, Gan YB, He J, Lin SE, Xu JK, Chang L, et al. Advancing skeletal health and disease research with single-cell RNA sequencing. Mil Med Res. 2024;11(1):33. DOI： 10.1186/s40779-024-00538-3.

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Advancing skeletal health and disease research with single-cell RNA sequencing

Advancing skeletal health and disease research with single-cell RNA sequencing

DOI：10.1186/s40779-024-00538-3