Gastroenteropancreatic neuroendocrine neoplasms: current development, challenges, and clinical perspectives

Xian-Bin Zhang; Yi-Bao Fan; Rui Jing; Mikiyas Amare Getu; Wan-Ying Chen; Wei Zhang; Hong-Xia Dong; Tikam Chand Dakal; Akhtar Hayat; Hua-Jun Cai; Milad Ashrafizadeh; A. M. Abd El-Aty; Ahmet Hacimuftuoglu; Peng Liu; Tian-Feng Li; Gautam Sethi; Kwang Seok Ahn; Yavuz Nuri Ertas; Min-Jiang Chen; Jian-Song Ji; Li Ma; Peng Gong

doi:10.1186/s40779-024-00535-6

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Gastroenteropancreatic neuroendocrine neoplasms: current development, challenges, and clinical perspectives

REVIEW | Updated：2025-12-13

- Gastroenteropancreatic neuroendocrine neoplasms: current development, challenges, and clinical perspectives
- Gastroenteropancreatic neuroendocrine neoplasms: current development, challenges, and clinical perspectives
- “本综述报告了神经内分泌肿瘤领域的最新研究，强调了在理解胃肠胰NEN的流行病学、临床表现、病理学、分子生物学、诊断和治疗方面的局限性和最新进展，为解决这些患者的诊断和及时治疗延误提供了解决方案。”
- MMR 2025年12卷第4期页码：579-599
- Affiliations：
  
  1.Department of General SurgeryInstitute of Precision Diagnosis and Treatment of Digestive System Tumors and Guangdong Provincial Key Laboratory of Chinese Medicine Ingredients and Gut Microbiomics, Carson International Cancer Center, Shenzhen University General Hospital, Shenzhen University, Shenzhen 518055, Guangdong, China
  2.School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen 518060, Guangdong, China
  3.Department of Radiology, Second Hospital of Shandong University, Jinan 250000, China
  4.Department of Gastroenterology, General Hospital of Chinese PLA, Beijing 100853, China
  5.Department of Biotechnology, Mohanlal Sukhadia University, Udaipur, Rajasthan 313001, India
  6.Interdisciplinary Research Centre in Biomedical Materials (IRCBM), COMSATS University Islamabad, Lahore Campus, Lahore 54000, Pakistan
  7.Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt
  8.Department of Medical Pharmacology, Medical Faculty, Ataturk University, Erzurum 25240, Turkey
  9.Reproductive Medicine Center, Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Shenzhen 518055, Guangdong, China
  10.Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore
  11.Department of Science in Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea
  12.ERNAM-Nanotechnology Research and Application Center, Erciyes University, Kayseri 38039, Türkiye
  13.Department of Biomedical Engineering, Erciyes University, Kayseri 38280, Türkiye
  14.UNAM−National Nanotechnology Research Center, Bilkent University, Ankara 06800, Türkiye
  15.Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, Zhejiang, China
  16.Department of Epidemiology, Dalian Medical University, Dalian 116044, Liaoning, China
- Author bio：
  
  *doctorgongpeng@szu.edu.cn
- Funds：
  
  the National Natural Science Foundation of China(82104596);the Shenzhen Key Medical Discipline Construction Fund & Sanming Project of Medicine in Shenzhen(SZSM202111002);the Medicine-Engineering Interdisciplinary Research Foundation of Shenzhen University(2023YG019);the Shenzhen Science and Technology Program(GJHZ20220913143005010)
- DOI：10.1186/s40779-024-00535-6
  中图分类号：
- 纸质出版：2025-04
- Accepted：
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Gastroenteropancreatic neuroendocrine neoplasms: current development, challenges, and clinical perspectives[J]. MMR, 2025,12(4):579-599.

Cite this article as: Zhang XB, Fan YB, Jing R, Getu MA, Chen WY, Zhang W, et al. Gastroenteropancreatic neuroendocrine neoplasms: current development, challenges, and clinical perspectives. Mil Med Res. 2024;11(1):35.
Gastroenteropancreatic neuroendocrine neoplasms: current development, challenges, and clinical perspectives[J]. MMR, 2025,12(4):579-599. DOI： 10.1186/s40779-024-00535-6.

Cite this article as: Zhang XB, Fan YB, Jing R, Getu MA, Chen WY, Zhang W, et al. Gastroenteropancreatic neuroendocrine neoplasms: current development, challenges, and clinical perspectives. Mil Med Res. 2024;11(1):35. DOI： 10.1186/s40779-024-00535-6.

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Gastroenteropancreatic neuroendocrine neoplasms: current development, challenges, and clinical perspectives

Gastroenteropancreatic neuroendocrine neoplasms: current development, challenges, and clinical perspectives

DOI：10.1186/s40779-024-00535-6